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PhotoStem SIGNED

Photoswitching molecules for the spatiotemporal control of cancer stem cells with light

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 PhotoStem project word cloud

Explore the words cloud of the PhotoStem project. It provides you a very rough idea of what is the project "PhotoStem" about.

models    cell    zebrafish    training    initially    small    effect    expertise    tumour    light    recognised    versions    vivo    stem    time    solid    achievement    induce    enormous    expansion    discovery    multidisciplinary    repression    chemotherapy    combine    molecules    modulators    xenograft    thought    tumours    bioactive    tumourigenesis    treatment    cells    cutting    disruptive    renew    similarities    bulk    learnings    photoswitchable    vitro    photopharmacology    truly    population    experts    mass    edge    relapse    characterised    leaders    herein    therapeutic    network    overcome    csc    innovation    function    biology    leukemia    constitutes    myeloid    expand    malignancies    normal    resistance    powerful    host    biological    selective    techniques    acts    existence    cancer    directions    researcher    inhibitors    precisely    leaving    cscs    self    patient    photoactivable    photostem    direction    spatiotemporal    tools    precise    urge    activation    despite    haematological    therapy    drug    space    unaffected   

Project "PhotoStem" data sheet

The following table provides information about the project.

Coordinator
AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS 

Organization address
address: CALLE SERRANO 117
city: MADRID
postcode: 28006
website: http://www.csic.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 160˙932 €
 EC max contribution 160˙932 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-09-01   to  2021-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS ES (MADRID) coordinator 160˙932.00

Map

 Project objective

PhotoStem aims to develop a cutting-edge approach to overcome the main cause of patient relapse in cancer treatment. Cancer stem cells (CSCs) are a small population of cells within a tumour characterised by their ability to self-renew and to induce tumourigenesis. Current chemotherapy acts only on the bulk of the tumour mass, leaving CSCs unaffected; this is thought to be the main cause of resistance to cancer treatment. Despite growing knowledge on the existence of CSCs, similarities to normal stem cells challenges the design of selective inhibitors and modulators. Relapse to cancer treatment is an enormous challenge and there is an urge to identify novel therapeutic approaches to target CSCs. Photopharmacology is an emerging field that seeks to precisely control the activity of bioactive molecules with light, allowing for activation or repression of biological function at a specific space and time. It constitutes a truly disruptive innovation that can represent a new direction in drug therapy. We herein propose to use novel photoactivable molecules to target CSCs with precise spatiotemporal control using light. Initially, we will develop novel photoswitchable versions of known inhibitors, and will study their effect in leukemia stem cells both in vitro and in zebrafish models. We will then expand our learnings to target CSCs of solid tumours. The achievement of such an ambitious objective will only be possible via a network of multidisciplinary researchers. The researcher will combine her expertise in drug discovery and leukemia with state-of-the-art photopharmacology techniques from leaders in the field at the host institution. Training-through-research at the partner organisations that include well-recognised experts in haematological malignancies, myeloid zebrafish models and CSC xenograft models will enable the expansion to in vivo applications. The proposed work will provide both new directions in targeted cancer therapy and powerful tools for cell biology.

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The information about "PHOTOSTEM" are provided by the European Opendata Portal: CORDIS opendata.

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