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PhotoStem SIGNED

Photoswitching molecules for the spatiotemporal control of cancer stem cells with light

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 PhotoStem project word cloud

Explore the words cloud of the PhotoStem project. It provides you a very rough idea of what is the project "PhotoStem" about.

similarities    precisely    photoswitchable    disruptive    cscs    enormous    expertise    leaders    unaffected    training    stem    light    inhibitors    biological    innovation    cell    existence    self    induce    mass    haematological    discovery    overcome    thought    precise    urge    spatiotemporal    herein    versions    therapy    zebrafish    network    chemotherapy    therapeutic    myeloid    techniques    drug    activation    molecules    malignancies    renew    combine    cancer    edge    solid    photostem    expansion    host    time    direction    bulk    resistance    expand    researcher    tumourigenesis    relapse    tools    treatment    directions    tumour    truly    function    cutting    modulators    leukemia    despite    constitutes    xenograft    acts    multidisciplinary    small    achievement    csc    initially    models    effect    population    leaving    vitro    patient    normal    learnings    powerful    bioactive    characterised    selective    recognised    photopharmacology    photoactivable    space    experts    biology    cells    vivo    repression    tumours   

Project "PhotoStem" data sheet

The following table provides information about the project.

Coordinator
AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS 

Organization address
address: CALLE SERRANO 117
city: MADRID
postcode: 28006
website: http://www.csic.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 160˙932 €
 EC max contribution 160˙932 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-09-01   to  2021-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS ES (MADRID) coordinator 160˙932.00

Map

 Project objective

PhotoStem aims to develop a cutting-edge approach to overcome the main cause of patient relapse in cancer treatment. Cancer stem cells (CSCs) are a small population of cells within a tumour characterised by their ability to self-renew and to induce tumourigenesis. Current chemotherapy acts only on the bulk of the tumour mass, leaving CSCs unaffected; this is thought to be the main cause of resistance to cancer treatment. Despite growing knowledge on the existence of CSCs, similarities to normal stem cells challenges the design of selective inhibitors and modulators. Relapse to cancer treatment is an enormous challenge and there is an urge to identify novel therapeutic approaches to target CSCs. Photopharmacology is an emerging field that seeks to precisely control the activity of bioactive molecules with light, allowing for activation or repression of biological function at a specific space and time. It constitutes a truly disruptive innovation that can represent a new direction in drug therapy. We herein propose to use novel photoactivable molecules to target CSCs with precise spatiotemporal control using light. Initially, we will develop novel photoswitchable versions of known inhibitors, and will study their effect in leukemia stem cells both in vitro and in zebrafish models. We will then expand our learnings to target CSCs of solid tumours. The achievement of such an ambitious objective will only be possible via a network of multidisciplinary researchers. The researcher will combine her expertise in drug discovery and leukemia with state-of-the-art photopharmacology techniques from leaders in the field at the host institution. Training-through-research at the partner organisations that include well-recognised experts in haematological malignancies, myeloid zebrafish models and CSC xenograft models will enable the expansion to in vivo applications. The proposed work will provide both new directions in targeted cancer therapy and powerful tools for cell biology.

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The information about "PHOTOSTEM" are provided by the European Opendata Portal: CORDIS opendata.

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