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Shape-shifting of vesicles induced by artificial tubular networks

Total Cost €


EC-Contrib. €






 SHINEShift project word cloud

Explore the words cloud of the SHINEShift project. It provides you a very rough idea of what is the project "SHINEShift" about.

distinctive    cells    compounds    tubules    colloidal    forces    spread    models    microfluidics    bilayer    static    edge    surrounding    competitive    horizontal    progress    disciplines    microscopy    transforming    msca    expertise    lipid    poor    pushing    grow    mechanical    transferable    resisting    reversible    dr    relevance    generate    artificial    cell    consisting    synthesis    preparation    fellowship    leadership    disassemble    time    manner    kudernac    science    expand    photo    brings    peptide    interdisciplinary    synthetic    responsive    inside    chemistry    me    stress    organic    ones    host    assemblies    stiff    leap    cyclic    fluid    dynamic    stops    passive    material    membrane    structures    switchable    techniques    fuel    fueling    objects    supramolecular    training    made    researcher    environment    stimuli    vesicles    biology    cutting    fundamental    skills    cytoskeleton    shape    scientific    notable    stabilizing    hence   

Project "SHINEShift" data sheet

The following table provides information about the project.


Organization address
postcode: 7522 NB

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 187˙572 €
 EC max contribution 187˙572 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-07-01   to  2021-06-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITEIT TWENTE NL (ENSCHEDE) coordinator 187˙572.00


 Project objective

The most commonly used artificial cell membrane models are vesicles. However, these static structures, consisting of a lipid bilayer surrounding a fluid, are poor in resisting mechanical stress. Enhancing their mechanical properties with a dynamic artificial cytoskeleton will both allow stabilizing their shape and transforming these passive objects into dynamic stimuli-responsive systems. In this MSCA project photo-responsive synthetic supramolecular tubules will be used as an artificial cytoskeleton inside vesicles. My aim is to develop stiff and at the same time responsive tubules based on cyclic peptide design that can grow and generate pushing forces during the fueling step, and disassemble when the fuel stops, both in a fully reversible manner. This cutting edge interdisciplinary project brings together several disciplines in chemistry, i.e. organic synthesis and supramolecular chemistry with colloidal chemistry (and/or microfluidics), and its scientific impact will spread through various fields – from supramolecular chemistry to material science (leap from static vesicles to dynamic ones), and synthetic biology (relevance for future applications in the field of artificial cells). My expertise as experienced researcher in the field of organic synthesis will be applied to the field of dynamic supramolecular systems based on photo-switchable compounds in which the host (Dr. Kudernac) has made notable recent progress. During this training-through-research project I will be able to learn the preparation processes for the vesicles and microscopy techniques that are fundamental for investigating (dynamic) supramolecular assemblies and which will further expand my horizontal skills. In addition, training activities during this fellowship will strongly enhance my leadership and transferable skills. Hence, the Fellowship will allow me to become a distinctive researcher in a highly competitive scientific environment.

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The information about "SHINESHIFT" are provided by the European Opendata Portal: CORDIS opendata.

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