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SHINEShift SIGNED

Shape-shifting of vesicles induced by artificial tubular networks

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 SHINEShift project word cloud

Explore the words cloud of the SHINEShift project. It provides you a very rough idea of what is the project "SHINEShift" about.

shape    stabilizing    fueling    forces    transferable    supramolecular    expertise    disassemble    stress    structures    chemistry    compounds    competitive    stops    switchable    poor    tubules    spread    brings    researcher    artificial    notable    surrounding    skills    stiff    resisting    distinctive    me    membrane    cutting    generate    photo    leadership    host    organic    training    dynamic    science    assemblies    models    vesicles    peptide    fundamental    stimuli    scientific    grow    expand    microscopy    objects    progress    preparation    lipid    fellowship    techniques    responsive    mechanical    material    leap    dr    cyclic    fuel    msca    colloidal    static    reversible    environment    transforming    synthesis    microfluidics    made    inside    interdisciplinary    cell    passive    cells    disciplines    edge    synthetic    hence    bilayer    pushing    relevance    kudernac    fluid    time    manner    ones    biology    cytoskeleton    consisting    horizontal   

Project "SHINEShift" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITEIT TWENTE 

Organization address
address: DRIENERLOLAAN 5
city: ENSCHEDE
postcode: 7522 NB
website: www.utwente.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 187˙572 €
 EC max contribution 187˙572 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-07-01   to  2021-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITEIT TWENTE NL (ENSCHEDE) coordinator 187˙572.00

Map

 Project objective

The most commonly used artificial cell membrane models are vesicles. However, these static structures, consisting of a lipid bilayer surrounding a fluid, are poor in resisting mechanical stress. Enhancing their mechanical properties with a dynamic artificial cytoskeleton will both allow stabilizing their shape and transforming these passive objects into dynamic stimuli-responsive systems. In this MSCA project photo-responsive synthetic supramolecular tubules will be used as an artificial cytoskeleton inside vesicles. My aim is to develop stiff and at the same time responsive tubules based on cyclic peptide design that can grow and generate pushing forces during the fueling step, and disassemble when the fuel stops, both in a fully reversible manner. This cutting edge interdisciplinary project brings together several disciplines in chemistry, i.e. organic synthesis and supramolecular chemistry with colloidal chemistry (and/or microfluidics), and its scientific impact will spread through various fields – from supramolecular chemistry to material science (leap from static vesicles to dynamic ones), and synthetic biology (relevance for future applications in the field of artificial cells). My expertise as experienced researcher in the field of organic synthesis will be applied to the field of dynamic supramolecular systems based on photo-switchable compounds in which the host (Dr. Kudernac) has made notable recent progress. During this training-through-research project I will be able to learn the preparation processes for the vesicles and microscopy techniques that are fundamental for investigating (dynamic) supramolecular assemblies and which will further expand my horizontal skills. In addition, training activities during this fellowship will strongly enhance my leadership and transferable skills. Hence, the Fellowship will allow me to become a distinctive researcher in a highly competitive scientific environment.

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The information about "SHINESHIFT" are provided by the European Opendata Portal: CORDIS opendata.

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