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Dissecting the impact of Lactate in Tuberculosis

Total Cost €


EC-Contrib. €






 Lac-TB project word cloud

Explore the words cloud of the Lac-TB project. It provides you a very rough idea of what is the project "Lac-TB" about.

property    transporters    researcher    group    privileged    outcome    interactions    llibre    extensive    equipped    communication    metabolomic    skills    intellectual    immunology    facilities    rare    reprogramming    metabolic    ing    lactate    immuno    reference    world    environment    therapeutics    infectious    revealing    learning    host    fourth    health    forefront    macrophages    macrophage    disease    tuberculosis    public    independent    university    resolution    directed    metabolism    opportunity    molecule    immune    cells    therapeutic    mauro    supervising    latently    fellowship    skillset    birmingham    infected    protect    expertise    dr    moving    obtain    tb    uob    uk    teaching    coordinate    pathogen    cellular    feasibility    training    highest    dictate    signalling    scientific    background    infection    team    glycolysis    rates    cell    crosstalk    population    mycobacterium    secure    active    context    supervisory    global    successful    laboratory   

Project "Lac-TB" data sheet

The following table provides information about the project.


Organization address
address: Edgbaston
postcode: B15 2TT

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 224˙933 €
 EC max contribution 224˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2021-12-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Tuberculosis (TB) is a major global public health problem in which one-fourth of the world’s population is latently infected. Host-directed therapeutics are a promising approach; however, we require a comprehensive understanding of how host-pathogen interactions impact signalling pathways and cellular responses to dictate disease outcome. Metabolic reprogramming of immune cells has been described during Mycobacterium tuberculosis (M.tb) infection, resulting in active glycolysis and lactate production. Lactate is an active signalling molecule and macrophages, the main M.tb cell target, can respond to it through different transporters. The main aim of this project is to investigate the crosstalk between metabolic and immune responses in the context of M.tb infection, with a particular focus on macrophage responses to lactate. This project has the potential of revealing new host immune-metabolic therapeutic targets for TB disease. Birmingham has one of the highest rates of TB in the UK and University of Birmingham (UoB) is a world-reference institution for metabolic and metabolomic studies. Dr Llibre has a strong background in immunology and moving to Dr Mauro’s laboratory at UoB will provide her with a rare opportunity to obtain a unique skillset, allowing her to study cell metabolism in high resolution. The expertise, facilities and supervisory team at the host institution, together with Dr Llibre’s extensive knowledge on immunology and infectious disease ensure the feasibility of this project. UoB will provide Dr Llibre a privileged environment to fully develop all the skills required to lead a successful research group, including training in scientific communication; opportunities for supervising and teaching, for learning how to coordinate a project and protect intellectual property. At the end of the fellowship, Dr Llibre will be at the forefront of the much needed and exciting field of immuno-metabolism, equipped to secure funding as an independent researcher.

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The information about "LAC-TB" are provided by the European Opendata Portal: CORDIS opendata.

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