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Lac-TB SIGNED

Dissecting the impact of Lactate in Tuberculosis

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 Lac-TB project word cloud

Explore the words cloud of the Lac-TB project. It provides you a very rough idea of what is the project "Lac-TB" about.

outcome    uk    fourth    independent    university    mauro    infection    pathogen    cell    cells    health    fellowship    infected    property    birmingham    resolution    opportunity    obtain    glycolysis    global    protect    training    uob    team    immuno    skillset    molecule    dr    latently    teaching    mycobacterium    directed    interactions    secure    group    privileged    immunology    macrophages    rates    expertise    transporters    reprogramming    communication    world    revealing    crosstalk    rare    metabolism    highest    tb    researcher    supervisory    successful    public    scientific    infectious    forefront    intellectual    disease    moving    equipped    host    signalling    feasibility    cellular    immune    learning    metabolomic    tuberculosis    skills    ing    facilities    population    dictate    macrophage    environment    context    therapeutics    therapeutic    llibre    laboratory    coordinate    extensive    metabolic    reference    background    supervising    lactate    active   

Project "Lac-TB" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF BIRMINGHAM 

Organization address
address: Edgbaston
city: BIRMINGHAM
postcode: B15 2TT
website: www.bham.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 224˙933 €
 EC max contribution 224˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2021-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF BIRMINGHAM UK (BIRMINGHAM) coordinator 224˙933.00

Map

 Project objective

Tuberculosis (TB) is a major global public health problem in which one-fourth of the world’s population is latently infected. Host-directed therapeutics are a promising approach; however, we require a comprehensive understanding of how host-pathogen interactions impact signalling pathways and cellular responses to dictate disease outcome. Metabolic reprogramming of immune cells has been described during Mycobacterium tuberculosis (M.tb) infection, resulting in active glycolysis and lactate production. Lactate is an active signalling molecule and macrophages, the main M.tb cell target, can respond to it through different transporters. The main aim of this project is to investigate the crosstalk between metabolic and immune responses in the context of M.tb infection, with a particular focus on macrophage responses to lactate. This project has the potential of revealing new host immune-metabolic therapeutic targets for TB disease. Birmingham has one of the highest rates of TB in the UK and University of Birmingham (UoB) is a world-reference institution for metabolic and metabolomic studies. Dr Llibre has a strong background in immunology and moving to Dr Mauro’s laboratory at UoB will provide her with a rare opportunity to obtain a unique skillset, allowing her to study cell metabolism in high resolution. The expertise, facilities and supervisory team at the host institution, together with Dr Llibre’s extensive knowledge on immunology and infectious disease ensure the feasibility of this project. UoB will provide Dr Llibre a privileged environment to fully develop all the skills required to lead a successful research group, including training in scientific communication; opportunities for supervising and teaching, for learning how to coordinate a project and protect intellectual property. At the end of the fellowship, Dr Llibre will be at the forefront of the much needed and exciting field of immuno-metabolism, equipped to secure funding as an independent researcher.

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The information about "LAC-TB" are provided by the European Opendata Portal: CORDIS opendata.

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