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Dissecting the impact of Lactate in Tuberculosis

Total Cost €


EC-Contrib. €






 Lac-TB project word cloud

Explore the words cloud of the Lac-TB project. It provides you a very rough idea of what is the project "Lac-TB" about.

macrophages    metabolism    background    dictate    therapeutics    revealing    tuberculosis    crosstalk    tb    supervising    feasibility    intellectual    birmingham    independent    cells    environment    skills    dr    mycobacterium    coordinate    lactate    mauro    group    extensive    university    researcher    expertise    opportunity    forefront    laboratory    health    infectious    moving    glycolysis    outcome    therapeutic    uob    successful    llibre    reference    latently    secure    uk    training    cell    highest    rare    cellular    teaching    skillset    public    privileged    protect    metabolomic    learning    disease    active    context    interactions    property    transporters    immuno    infected    fourth    resolution    molecule    world    communication    infection    ing    supervisory    host    obtain    directed    population    macrophage    immune    immunology    scientific    fellowship    metabolic    reprogramming    equipped    rates    pathogen    signalling    global    facilities    team   

Project "Lac-TB" data sheet

The following table provides information about the project.


Organization address
address: Edgbaston
postcode: B15 2TT

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 224˙933 €
 EC max contribution 224˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2021-12-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Tuberculosis (TB) is a major global public health problem in which one-fourth of the world’s population is latently infected. Host-directed therapeutics are a promising approach; however, we require a comprehensive understanding of how host-pathogen interactions impact signalling pathways and cellular responses to dictate disease outcome. Metabolic reprogramming of immune cells has been described during Mycobacterium tuberculosis (M.tb) infection, resulting in active glycolysis and lactate production. Lactate is an active signalling molecule and macrophages, the main M.tb cell target, can respond to it through different transporters. The main aim of this project is to investigate the crosstalk between metabolic and immune responses in the context of M.tb infection, with a particular focus on macrophage responses to lactate. This project has the potential of revealing new host immune-metabolic therapeutic targets for TB disease. Birmingham has one of the highest rates of TB in the UK and University of Birmingham (UoB) is a world-reference institution for metabolic and metabolomic studies. Dr Llibre has a strong background in immunology and moving to Dr Mauro’s laboratory at UoB will provide her with a rare opportunity to obtain a unique skillset, allowing her to study cell metabolism in high resolution. The expertise, facilities and supervisory team at the host institution, together with Dr Llibre’s extensive knowledge on immunology and infectious disease ensure the feasibility of this project. UoB will provide Dr Llibre a privileged environment to fully develop all the skills required to lead a successful research group, including training in scientific communication; opportunities for supervising and teaching, for learning how to coordinate a project and protect intellectual property. At the end of the fellowship, Dr Llibre will be at the forefront of the much needed and exciting field of immuno-metabolism, equipped to secure funding as an independent researcher.

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The information about "LAC-TB" are provided by the European Opendata Portal: CORDIS opendata.

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lastchecktime (2022-12-04 1:05:56) correctly updated