Opendata, web and dolomites

SWEET-PI SIGNED

Aromatic stacking in Glycochemistry: can glycosidations be tamed?

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 SWEET-PI project word cloud

Explore the words cloud of the SWEET-PI project. It provides you a very rough idea of what is the project "SWEET-PI" about.

chemical    functional    detection    glycosyltransferases    interaction    reactive    group    acceptor    participation    catalysis    requiring    models    molecules    stabilized    aromatic    expansion    glycosyl    course    never    central    alternatively    oxocarbenium    donor    glycoscience    synthesis    accepted    reactivity    hypothesis    too    species    carboxylates    variety    elusive    interactions    carbohydrate    stacking    density    stabilize    electron    ch    life    conformational    bioorganic    potentially    nucleophilicity    supramolecular    despite    enzymatic    glycostructures    systematic    first    modulation    bond    intermediates    intermediate    detected    complexes    molecular    intramolecular    progress    extend    contacts    glycosidation    glycosidases    employing    glycosidic    motifs    stability    frequently    outcome    interestingly    reaction    time    play    ion    inter    employed    revolves    appropriate    cationic    chemistry    invoked    groups    transient    stereochemical    recognition    fact    ionic    pi    idea   

Project "SWEET-PI" data sheet

The following table provides information about the project.

Coordinator
AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS 

Organization address
address: CALLE SERRANO 117
city: MADRID
postcode: 28006
website: http://www.csic.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 172˙932 €
 EC max contribution 172˙932 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2021-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS ES (MADRID) coordinator 172˙932.00

Map

 Project objective

Progress in chemical synthesis has provided access to a large variety of complex glycostructures, having a major impact in the expansion of Glycoscience. Central to carbohydrate chemistry is the glycosidation reaction, which involves the formation of a glycosidic bond between donor and acceptor molecules. It is commonly accepted that this process requires the formation of transient ionic species, whose stability, conformational properties and interactions determine to a large extend the reaction outcome. In principle, these elusive species are stabilized by means of inter- and intramolecular interactions, and in fact, this is a key feature for the activity of glycosidases and glycosyltransferases, typically requiring the participation of electron-rich functional groups, such as carboxylates. Interestingly, aromatic/carbohydrate interactions have too been detected and evaluated as supramolecular recognition motifs but, to the best of our knowledge, never at the reaction intermediate level, despite being frequently invoked to play a major role during enzymatic catalysis. Our hypothesis in this project revolves around the idea that stacking interactions involving electron-rich aromatic systems can be employed to stabilize the glycosyl oxocarbenium ion and to enhance the glycosyl acceptor reactivity; in the first case, these contacts might increase the life-time of the cationic intermediates, facilitating their detection and potentially allowing the modulation of the glycosidic donor in order to better control the stereochemical course of the reaction. Alternatively, CH/pi complexes involving the glycosyl acceptor could enhance the electron density of the reactive functional group, thus its nucleophilicity. This project aims to test both aspects of the carbohydrate/aromatic interaction employing a bioorganic approach based on the design, synthesis and systematic analysis of appropriate molecular models.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "SWEET-PI" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "SWEET-PI" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

ICARUS (2020)

Information Content of locAlisation: fRom classical to qUantum Systems

Read More  

ReSOLeS (2019)

New Reconfigurable Spectrum Optical Fibre Laser Sources

Read More  

TOPOCIRCUS (2019)

Simulations of Topological Phases in Superconducting Circuits

Read More