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Polymeric cyclodextrin-based nanoparticles for combination therapy of castrate-resistant prostate cancer

Total Cost €


EC-Contrib. €






 POLAR STAR project word cloud

Explore the words cloud of the POLAR STAR project. It provides you a very rough idea of what is the project "POLAR STAR" about.

fda    strategy    vivo    pc    cultures    nanocarrier    resistant    cyclodextrins    battle    tracking    models    efficacy    reduce    teams    therapeutic    oncogenic    biological    treat    worldwide    hosting    advantage    biocompatible    supervisor    mind    creates    nanocarriers    combination    plan    characterization    form    clinical    chances    treatment    possibility    tissue    keeping    organic    selectivity    approved    fellow    academic    castrate    lot    secondments    holds    resistance    benefit    researcher    multidrug    tests    complementary    patient    full    apporach    multiple    latest    final    therapy    nanotechnology    physical    survival    polar    guided    exert    chemistry    mixed    actors    administer    prostate    premises    experiments    pursued    skills    blocks    contemporarily    transfer    private    innovative    loaded    expertise    cell    3d    agents    drug    overcome    upgrade    cancer    frame    building    animal    chemico    profiles    drugs    complete    environment    suffering    forefront    cargo    nanomedicine    polymers    leaving    synergically    reciprocal    multidisciplinary    public    fifth    responsivity    few    death    polymeric    star   

Project "POLAR STAR" data sheet

The following table provides information about the project.


Organization address
city: ROMA
postcode: 185

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 171˙473 €
 EC max contribution 171˙473 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-06-01   to  2021-05-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Prostate cancer (PC) is the fifth leading cause of cancer-related death worldwide. PC often presents in its Multidrug resistant form leaving the patient few survival chances. New approaches are required to overcome resistance-related problems in PC and nanomedicine holds a lot of premises to effectively contribute in this battle. In this frame POLAR STAR aims at the implementation of combination therapy to treat castrate-resistant PC. Our strategy is to exploit innovative nanotechnology to administer contemporarily different therapeutic agents that synergically exert their activity across multiple oncogenic pathways. We plan to use new mixed polymers based on biocompatible cyclodextrins as these building blocks are already FDA approved. Simple organic chemistry is pursued to implement target selectivity and in vivo tracking of the polymeric nanocarrier. The design is guided by the final goal, the future clinical application of nanocarriers to improve PC treatment, keeping in mind upgrade of the nanocarrier systems to large scale production. We will focus on the latest PC drugs suffering from side effects and emerging resistance as multiple cargo to be loaded. Full chemico-physical characterization of the systems is planned as well as assessment of the efficacy of loaded nanocarriers in cell cultures with different drug responsivity profiles. In order to reduce animal experiments POLAR STAR will take full advantage of 3D prostate tissue models for biological tests, an apporach at the forefront in drug design. We plan to reach our goal bringing together the expertise of the fellow and the supervisor supported by the private and academic teams hosting the fellow during secondments. POLAR STAR creates a multidisciplinary environment where all actors, public and private, will benefit from reciprocal transfer of knowledge. During the project the fellow will have the possibility to become a complete researcher improving also complementary skills.

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The information about "POLAR STAR" are provided by the European Opendata Portal: CORDIS opendata.

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