Opendata, web and dolomites

POLAR STAR SIGNED

Polymeric cyclodextrin-based nanoparticles for combination therapy of castrate-resistant prostate cancer

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 POLAR STAR project word cloud

Explore the words cloud of the POLAR STAR project. It provides you a very rough idea of what is the project "POLAR STAR" about.

clinical    strategy    complementary    lot    cell    upgrade    keeping    blocks    reduce    cargo    polar    organic    private    fda    skills    creates    holds    cultures    synergically    nanocarriers    frame    polymeric    tests    biological    therapy    supervisor    death    3d    transfer    drug    leaving    full    battle    experiments    forefront    chemico    administer    few    building    environment    characterization    prostate    multidisciplinary    chemistry    latest    actors    castrate    pc    combination    responsivity    loaded    teams    final    tissue    star    complete    cyclodextrins    suffering    selectivity    therapeutic    reciprocal    multiple    treat    resistant    mixed    nanocarrier    worldwide    advantage    multidrug    survival    treatment    vivo    agents    physical    approved    innovative    exert    fellow    animal    expertise    biocompatible    premises    polymers    plan    apporach    tracking    researcher    overcome    drugs    possibility    pursued    models    contemporarily    hosting    nanotechnology    profiles    nanomedicine    public    resistance    efficacy    patient    form    cancer    fifth    mind    chances    secondments    guided    benefit    academic    oncogenic   

Project "POLAR STAR" data sheet

The following table provides information about the project.

Coordinator
CONSIGLIO NAZIONALE DELLE RICERCHE 

Organization address
address: PIAZZALE ALDO MORO 7
city: ROMA
postcode: 185
website: www.cnr.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 171˙473 €
 EC max contribution 171˙473 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-06-01   to  2021-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CONSIGLIO NAZIONALE DELLE RICERCHE IT (ROMA) coordinator 171˙473.00

Map

 Project objective

Prostate cancer (PC) is the fifth leading cause of cancer-related death worldwide. PC often presents in its Multidrug resistant form leaving the patient few survival chances. New approaches are required to overcome resistance-related problems in PC and nanomedicine holds a lot of premises to effectively contribute in this battle. In this frame POLAR STAR aims at the implementation of combination therapy to treat castrate-resistant PC. Our strategy is to exploit innovative nanotechnology to administer contemporarily different therapeutic agents that synergically exert their activity across multiple oncogenic pathways. We plan to use new mixed polymers based on biocompatible cyclodextrins as these building blocks are already FDA approved. Simple organic chemistry is pursued to implement target selectivity and in vivo tracking of the polymeric nanocarrier. The design is guided by the final goal, the future clinical application of nanocarriers to improve PC treatment, keeping in mind upgrade of the nanocarrier systems to large scale production. We will focus on the latest PC drugs suffering from side effects and emerging resistance as multiple cargo to be loaded. Full chemico-physical characterization of the systems is planned as well as assessment of the efficacy of loaded nanocarriers in cell cultures with different drug responsivity profiles. In order to reduce animal experiments POLAR STAR will take full advantage of 3D prostate tissue models for biological tests, an apporach at the forefront in drug design. We plan to reach our goal bringing together the expertise of the fellow and the supervisor supported by the private and academic teams hosting the fellow during secondments. POLAR STAR creates a multidisciplinary environment where all actors, public and private, will benefit from reciprocal transfer of knowledge. During the project the fellow will have the possibility to become a complete researcher improving also complementary skills.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "POLAR STAR" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "POLAR STAR" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

MultiSeaSpace (2019)

Developing a unified spatial modelling strategy that accounts for interactions between species at different marine trophic levels, and different types of survey data.

Read More  

INSPiRE (2018)

The Influence of Information Search on Preference Formation and Choice

Read More  

CIGNUS (2019)

CuInGaSe Nanowires Under the Sun

Read More