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POLAR STAR SIGNED

Polymeric cyclodextrin-based nanoparticles for combination therapy of castrate-resistant prostate cancer

Total Cost €

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EC-Contrib. €

0

Partnership

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 POLAR STAR project word cloud

Explore the words cloud of the POLAR STAR project. It provides you a very rough idea of what is the project "POLAR STAR" about.

drug    apporach    complementary    treatment    drugs    battle    nanotechnology    forefront    treat    animal    plan    tests    models    creates    blocks    public    therapy    profiles    secondments    hosting    death    upgrade    biological    keeping    innovative    expertise    supervisor    prostate    resistance    physical    vivo    oncogenic    survival    characterization    reduce    therapeutic    multidisciplinary    guided    holds    transfer    star    advantage    few    3d    complete    academic    fda    cultures    administer    building    agents    mind    latest    suffering    selectivity    benefit    private    reciprocal    nanocarriers    resistant    fifth    actors    cancer    tracking    polymers    possibility    premises    biocompatible    exert    fellow    multiple    castrate    full    clinical    pursued    nanomedicine    synergically    pc    cell    cyclodextrins    nanocarrier    chemico    frame    researcher    chances    teams    patient    chemistry    approved    polymeric    responsivity    organic    leaving    environment    lot    worldwide    multidrug    cargo    efficacy    combination    form    overcome    polar    experiments    strategy    loaded    contemporarily    skills    tissue    final    mixed   

Project "POLAR STAR" data sheet

The following table provides information about the project.

Coordinator
CONSIGLIO NAZIONALE DELLE RICERCHE 

Organization address
address: PIAZZALE ALDO MORO 7
city: ROMA
postcode: 185
website: www.cnr.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 171˙473 €
 EC max contribution 171˙473 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-06-01   to  2021-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CONSIGLIO NAZIONALE DELLE RICERCHE IT (ROMA) coordinator 171˙473.00

Map

 Project objective

Prostate cancer (PC) is the fifth leading cause of cancer-related death worldwide. PC often presents in its Multidrug resistant form leaving the patient few survival chances. New approaches are required to overcome resistance-related problems in PC and nanomedicine holds a lot of premises to effectively contribute in this battle. In this frame POLAR STAR aims at the implementation of combination therapy to treat castrate-resistant PC. Our strategy is to exploit innovative nanotechnology to administer contemporarily different therapeutic agents that synergically exert their activity across multiple oncogenic pathways. We plan to use new mixed polymers based on biocompatible cyclodextrins as these building blocks are already FDA approved. Simple organic chemistry is pursued to implement target selectivity and in vivo tracking of the polymeric nanocarrier. The design is guided by the final goal, the future clinical application of nanocarriers to improve PC treatment, keeping in mind upgrade of the nanocarrier systems to large scale production. We will focus on the latest PC drugs suffering from side effects and emerging resistance as multiple cargo to be loaded. Full chemico-physical characterization of the systems is planned as well as assessment of the efficacy of loaded nanocarriers in cell cultures with different drug responsivity profiles. In order to reduce animal experiments POLAR STAR will take full advantage of 3D prostate tissue models for biological tests, an apporach at the forefront in drug design. We plan to reach our goal bringing together the expertise of the fellow and the supervisor supported by the private and academic teams hosting the fellow during secondments. POLAR STAR creates a multidisciplinary environment where all actors, public and private, will benefit from reciprocal transfer of knowledge. During the project the fellow will have the possibility to become a complete researcher improving also complementary skills.

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The information about "POLAR STAR" are provided by the European Opendata Portal: CORDIS opendata.

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