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OLECAT SIGNED

Development of Stereoselective Olefin Functionalization Methods

Total Cost €

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EC-Contrib. €

0

Partnership

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 OLECAT project word cloud

Explore the words cloud of the OLECAT project. It provides you a very rough idea of what is the project "OLECAT" about.

bioactive    beneficial    preparation    carnitine    mn    saturated    environmentally    discovery    co    pharma    abundant    diastereo    classes    dienes    time    regard    catalytic    olefinic    medicines    azides    acids    small    fe    amines    sustainable    chiral    utilize    metals    convenient    bicyclic    reactions    serve    stereochemically    readily    structures    regio    allylation    form    boronic    trienes    carboxylic    substantially    olefin    catalyst    aldol    executed    starting    agents    economically    strategies    routes    blocks    fragments    pyrrolidines    active    nutraceuticals    enantioselective    ligands    alcohols    materials    molecule    easily    pyrans    chemo    polyols    hydrazines    chemical    tenable    convergent    oxidation    boric    building    incorporate    collection    acyclic    stereochemical    furans    functionalization    earth    efficient    piperidines    cyclic    enantioselectivity    patterns    structural    unsaturated    convert    optically    synthesis    catalysts    nitriles    found    settings    discover   

Project "OLECAT" data sheet

The following table provides information about the project.

Coordinator
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH 

Organization address
address: Raemistrasse 101
city: ZUERICH
postcode: 8092
website: https://www.ethz.ch/de.html

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 2˙498˙635 €
 EC max contribution 2˙498˙635 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-ADG
 Funding Scheme ERC-ADG
 Starting year 2019
 Duration (year-month-day) from 2019-09-01   to  2024-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH CH (ZUERICH) coordinator 2˙498˙635.00

Map

 Project objective

The ability toThe ability to readily access small-molecule building blocks at will has important consequences for the discovery and development of novel medicines and materials. It is particularly beneficial when the chemical methods are convenient while at the same time economically and environmentally tenable and sustainable. We are especially interested in catalytic processes that are easily executed and utilize readily available starting materials to produce optically active products with high regio, chemo, diastereo, and enantioselectivity. The proposal aims to discover, develop, and study a collection of enantioselective olefin functionalization reactions that provide access to useful building blocks, such as amines, azides, hydrazines, nitriles, alcohols, involving acyclic, cyclic and bicyclic structures. The catalyst will be derived from earth abundant metals, such as Fe, Mn, and Co and incorporate novel chiral ligands. The study includes the design and preparation of two structural classes of novel, chiral boric acids that are expected to serve as catalyst for the enantioselective functionalization of unsaturated carboxylic acids and boronic acids. The methods are expected to substantially impact the development of novel strategies for complex molecule synthesis. In this regard, we propose to use the catalysts form this study to convert dienes and trienes into polyols with characteristic stereochemical and oxidation patterns found in bioactive agents, including pharma- and nutraceuticals (carnitine). Such advances enable new approaches that go beyond the well-established methods such as aldol/allylation for the preparation of stereochemically complex fragments. Catalysts will also be developed that convert acyclic olefinic alcohols and amines into optically active, saturated furans, pyrans, pyrrolidines, and piperidines. The implementation of the various catalytic methods in complex settings enables efficient, convergent routes to bioactive agents.

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The information about "OLECAT" are provided by the European Opendata Portal: CORDIS opendata.

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