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SATURN

Impact of Specific Antibiotic Therapies on the prevalence of hUman host ResistaNt bacteria

Coordinatore	UNIVERSITE DE GENEVE Organization address address: Rue du General Dufour 24 city: GENEVE postcode: 1211 contact info Titolo: Dr. Nome: Stephan Jurgen Cognome: Harbarth Email: send email Telefono: 41223723357 Fax: 41223723987
Nazionalità Coordinatore	Switzerland [CH]
Totale costo	7˙821˙538 €
EC contributo	5˙999˙436 €
Programma	FP7-HEALTH Specific Programme "Cooperation": Health
Code Call	FP7-HEALTH-2009-single-stage
Funding Scheme	CP-FP
Anno di inizio	2010
Periodo (anno-mese-giorno)	2010-01-01 - 2014-12-31

Partecipanti

#	participant	country	role	EC contrib. [€]
1	UNIVERSITE DE GENEVE Organization address address: Rue du General Dufour 24 city: GENEVE postcode: 1211 contact info Titolo: Dr. Nome: Stephan Jurgen Cognome: Harbarth Email: send email Telefono: 41223723357 Fax: 41223723987	CH (GENEVE)	coordinator	684˙400.00
2	UNIVERSITEIT ANTWERPEN Organization address address: PRINSSTRAAT 13 city: ANTWERPEN postcode: 2000 contact info Titolo: Ms. Nome: Anne Cognome: Adams Email: send email Telefono: +32 3 2653028 Fax: +32 3 2653011	BE (ANTWERPEN)	participant	1˙017˙911.00
3	THE FOUNDATION FOR MEDICAL RESEARCHINFRASTRUCTURAL DEVELOPMENT AND HEALTH SERVICES NEXT TO THE MEDICAL CENTER TEL AVIV Organization address address: WEIZMANN STREET 6 city: Tel Aviv postcode: 64239 contact info Titolo: Dr. Nome: Michal Cognome: Roll Email: send email Telefono: +972 36974761 Fax: +972 36925739	IL (Tel Aviv)	participant	922˙947.00
4	UNIVERSITAIR MEDISCH CENTRUM UTRECHT Organization address address: HEIDELBERGLAAN 100 city: UTRECHT postcode: 3584 CX contact info Titolo: Prof. Nome: Anne-Marie Cognome: Laeven Email: send email Telefono: +31 887568181 Fax: +31 887568099	NL (UTRECHT)	participant	806˙190.00
5	UNIVERSITA CATTOLICA DEL SACRO CUORE Organization address address: Largo Agostino Gemelli 1 city: MILANO postcode: 20123 contact info Titolo: Mr. Nome: Filippo Cognome: Leone Email: send email Telefono: +39 06 30156099 Fax: +39 06 30156803	IT (MILANO)	participant	592˙349.60
6	ARTTIC Organization address address: Rue du Dessous des Berges 58A city: PARIS postcode: 75013 contact info Titolo: Dr. Nome: Eric Cognome: Papon Email: send email Telefono: +33 153945460 Fax: +33 153945470	FR (PARIS)	participant	374˙041.30
7	STICHTING KATHOLIEKE UNIVERSITEIT Organization address address: GEERT GROOTEPLEIN NOORD 9 city: NIJMEGEN postcode: 6525 EZ contact info Titolo: Dr. Nome: Johan Willem Cognome: Mouton Email: send email Telefono: +31 24 361 4356 Fax: +31 24 356 4606	NL (NIJMEGEN)	participant	373˙549.00
8	CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER Organization address address: CALLE ROSSELLO 149 PUERTA BJS city: BARCELONA postcode: 8036 contact info Titolo: Prof. Nome: Ramon Cognome: Gomis Email: send email Telefono: 34932279884 Fax: 34932279205	ES (BARCELONA)	participant	267˙567.80
9	ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS Organization address address: 3 Avenue Victoria city: PARIS postcode: 75004 contact info Titolo: Mr. Nome: Christophe Cognome: Misse Email: send email Telefono: +33 1 40 27 46 13	FR (PARIS)	participant	235˙389.74
10	JULIUS-MAXIMILIANS UNIVERSITAET WUERZBURG Organization address address: SANDERRING 2 city: WUERZBURG postcode: 97070 contact info Titolo: Mr. Nome: Christian Cognome: Gloggengiesser Email: send email Telefono: +49 931312294 Fax: +49 9318887180	DE (WUERZBURG)	participant	212˙987.00
11	UNIVERSYTET MEDYCZNY W LODZI. Organization address address: Al. Kosciuszki, 4 city: LODZ postcode: 90419 contact info Titolo: Dr. Nome: Maciej Cognome: Godycki-Cwirko Email: send email Telefono: +48 42 679 55 46 Fax: +48 42 678 60 41	PL (LODZ)	participant	178˙761.80
12	INSTITUTE FOR INFECTIOUS DISEASES PROF DR. MATEI BALS Organization address address: Street Dr. C. Grozovici 1 1 city: Bucharest postcode: 21105 contact info Titolo: Ms. Nome: Daniela Cognome: Dumitrascu Email: send email Telefono: +40 721614981	RO (Bucharest)	participant	145˙975.00
13	Clinical Center of Serbia Organization address address: Pasterova 2 city: Belgrade postcode: 11000 contact info Titolo: Dr. Nome: Zivan Cognome: Maksimovic Email: send email Telefono: +381 11 2644850 Fax: +381 11 3067198	RS (Belgrade)	participant	145˙103.30
14	EBERHARD KARLS UNIVERSITAET TUEBINGEN Organization address address: GESCHWISTER-SCHOLL-PLATZ city: TUEBINGEN postcode: 72074 contact info Titolo: Prof. Nome: Evelina Cognome: Tacconelli Email: send email Telefono: +49 7071 29 85020 Fax: +49 7071 29 25074	DE (TUEBINGEN)	participant	34˙811.60
15	Fondation hopital Saint Joseph Organization address address: Rue Raymond Losserand 185 city: Paris postcode: 75674 contact info Titolo: Mr. Nome: Philippe Cognome: Fradin Email: send email Telefono: 33144123482 Fax: 33144123870	FR (Paris)	participant	7˙451.86
16	STICHTING NIJMEEGS INTERCONFESSIONEEL ZIEKENHUIS CANISIUS WILHELMINA Organization address address: WEG DOOR JONKERBOS 100 city: NIJMEGEN postcode: 6532SZ contact info Titolo: Dr. Nome: Johan Willem Cognome: Mouton Email: send email Telefono: +31 24 365 7514 Fax: + 31 24 3657516	NL (NIJMEGEN)	participant	0.00

Mappa

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mechanisms antibiotic molecular saturn resistant amr bacteria combining randomized exposure effect impact clinical fluoroquinolone emergence

Obiettivo del progetto (Objective)

'Many results drawn from previous studies of the effect of antibiotic use on emergence, selection and spread of antimicrobial resistance (AMR) have lacked a holistic view combining all aspects into one study. The SATURN project aims to study the impact of antibiotic exposure on AMR with a multidisciplinary approach that bridges molecular, epidemiological, clinical and pharmacological research. Two types of clinical studies will be conducted: First, a randomized trial will be performed to resolve an issue of high controversy (antibiotic cycling vs. mixing). Second, 3 observational studies will be conducted to rigorously study issues surrounding the effect of antibiotic use on AMR that are not easily assessable through randomized trials. These clinical studies will serve as a platform to 2 complementary workpackages (microbiology & pharmacology) that will perform important investigations relevant to this call. The work package focusing on molecular studies will generate new evidence about the changes effected by antibiotic therapy on commensal organisms or opportunistic pathogens in the oropharyngeal, nasal and gastro-intestinal flora and study AMR mechanisms and the dissemination of successful clones of fluoroquinolone-resistant, carbapenem-resistant or extended-spectrum beta-lactamase harboring Gram-negative bacteria, MRSA and fluoroquinolone-resistant viridans streptococci. The purpose of the pharmacodynamic study is to model the relationships between antibiotic exposure and AMR emergence over time for various classes of agents. In summary, the overarching rationale of SATURN is to improve methodological standards and conduct research that will help to better understand the impact of antibiotic use on acquisition, selection and transmission of AMR in different environments, by combining analyses of molecular, individual patient-level and ecologic data. The anticipated results may guide clinical and policy decisions to ultimately reduce the burden of AMR in Europe.'

Introduzione (Teaser)

Antibiotic misuse triggers the emergence of drug-resistant bacteria. Understanding the mechanisms underlying this phenomenon should help develop appropriate measures.