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SMARTBOX SIGNED

Selective Modifications of ARomatics through Biocatalytic Oxidations

Total Cost €

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EC-Contrib. €

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Partnership

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Project "SMARTBOX" data sheet

The following table provides information about the project.

Coordinator
BIO BASE EUROPE PILOT PLANT VZW 

Organization address
address: RODENHUIZEKAAI 1
city: DESTELDONK GENT
postcode: 9042
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 4˙511˙562 €
 EC max contribution 3˙924˙163 € (87%)
 Programme 1. H2020-EU.2.1.4. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Biotechnology)
2. H2020-EU.3.2. (SOCIETAL CHALLENGES - Food security, sustainable agriculture and forestry, marine, maritime and inland water research, and the bioeconomy)
 Code Call H2020-BBI-JTI-2018
 Funding Scheme BBI-RIA
 Starting year 2019
 Duration (year-month-day) from 2019-05-01   to  2023-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    BIO BASE EUROPE PILOT PLANT VZW BE (DESTELDONK GENT) coordinator 885˙375.00
2    KATHOLIEKE UNIVERSITEIT LEUVEN BE (LEUVEN) participant 807˙750.00
3    RIJKSUNIVERSITEIT GRONINGEN NL (GRONINGEN) participant 418˙867.00
4    AVA BIOCHEM BSL AG CH (MUTTENZ) participant 391˙875.00
5    UNIVERSIDADE NOVA DE LISBOA PT (LISBOA) participant 325˙521.00
6    QUANTIS CH (ECUBLENS VD) participant 322˙500.00
7    UNIVERSITA DEGLI STUDI DI PAVIA IT (PAVIA) participant 303˙750.00
8    B4PLASTICS BE (MAASMECHELEN) participant 262˙400.00
9    ZYMVOL BIOMODELING SL ES (LLEIDA) participant 206˙125.00
10    BORREGAARD AS NO (SARPSBORG) participant 0.00
11    COVESTRO DEUTSCHLAND AG DE (LEVERKUSEN) participant 0.00

Map

 Project objective

Although they have the potential to improve the economic and environmental sustainability of biorefineries, oxidative enzymes have not experienced a complete breakthrough yet in the biobased industries. This is mainly caused by the high cost and long time associated with traditional enzyme engineering methods such as directed evolution. SMARTBOX will develop an advanced computational engineering platform specifically for oxidative enzymes, which can automatically screen for improved enzyme variants with minimal human intervention. This is achieved by implementing several innovations into current computational screening methods, most importantly machine learning, which allows to train the algorithms with experimental results. As this significantly improves computational predictability, the time and costs associated with oxidative enzyme engineering will be reduced 10-fold compared to state-of-the-art (SOTA) directed evolution methods.

Relying on the advanced engineering platform, SMARTBOX will develop the one-enzyme conversion of HMF into FDCA and intermediates, and the one-enzyme conversion of lignin monomers into a potential biobased building block for polycarbonates and vanillin. By adopting a 1-enzyme FDCA production process, the associated production costs and carbon footprint are expected to decrease significantly compared to SOTA chemical oxidation methods. The unique feature of SMARTBOX is that reductive catalytic fractionation (RCF) will be used to selectively produce specific lignin monomers from biomass in near theoretical yields. The structural similarity of the resulting monomers with the SMARTBOX building blocks allows the development of high-yielding processes with only one enzyme. Due to the smart combination between oxidative biocatalysis and RCF, the production of bio-aromatics will proceed with higher yields than the state of the art.

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The information about "SMARTBOX" are provided by the European Opendata Portal: CORDIS opendata.

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lastchecktime (2021-02-25 4:54:12) correctly updated