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ANTHROPOID SIGNED

Great ape organoids to reconstruct uniquely human development

Total Cost €

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EC-Contrib. €

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Partnership

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 ANTHROPOID project word cloud

Explore the words cloud of the ANTHROPOID project. It provides you a very rough idea of what is the project "ANTHROPOID" about.

cellular    difficult    reshape    explore    divergence    transcriptomics    entire    ancestralize    ago    dimensional    colonize    starting    cognition    diverged    planet    genetic    screens    adaptive    ground    vision    programs    chimpanzee    function    organ    resolution    cortex    risk    neandertals    metabolism    closest    pluripotent    million    transcriptome    resurrect    recapitulate    intestine    genome    self    human    point    genomic    ancient    tackle    cell    culture    developmental    dissect    apes    organize    apart    branches    capacity    biosphere    organoids    ape    morphology    liver    questions    anthropoid    utilizes    complexity    quantitative    altered    question    evolution    replay    modern    generate    single    relatives    ancestors    enhancer    small    organisms    uniquely    chimpanzees    breaking    lineage    humans    multiple    comparisons    evolutionary    tissues    endowed    phenotypes    species    enhanced    innovations    stem    physiology    metabolic    3d    acquired    living    atlas    pscs    lack    cognitive    chromatin    cells    functional    accessibility   

Project "ANTHROPOID" data sheet

The following table provides information about the project.

Coordinator
INSTITUT FUR MOLEKULARE UND KLINISCHE OPHTHALMOLOGIE BASEL 

Organization address
address: C/O UNIVERSITÄTSSPITAL BASEL, AUGENKLINIK, MITTLERE STRASSE
city: BASEL
postcode: 4056
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-06-01   to  2024-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT FUR MOLEKULARE UND KLINISCHE OPHTHALMOLOGIE BASEL CH (BASEL) coordinator 1˙500˙000.00

Map

 Project objective

Humans diverged from our closest living relatives, chimpanzees and other great apes, 6-10 million years ago. Since this divergence, our ancestors acquired genetic changes that enhanced cognition, altered metabolism, and endowed our species with an adaptive capacity to colonize the entire planet and reshape the biosphere. Through genome comparisons between modern humans, Neandertals, chimpanzees and other apes we have identified genetic changes that likely contribute to innovations in human metabolic and cognitive physiology. However, it has been difficult to assess the functional effects of these genetic changes due to the lack of cell culture systems that recapitulate great ape organ complexity. Human and chimpanzee pluripotent stem cells (PSCs) can self-organize into three-dimensional (3D) tissues that recapitulate the morphology, function, and genetic programs controlling organ development. Our vision is to use organoids to study the changes that set modern humans apart from our closest evolutionary relatives as well as all other organisms on the planet. In ANTHROPOID we will generate a great ape developmental cell atlas using cortex, liver, and small intestine organoids. We will use single-cell transcriptomics and chromatin accessibility to identify cell type-specific features of transcriptome divergence at cellular resolution. We will dissect enhancer evolution using single-cell genomic screens and ancestralize human cells to resurrect pre-human cellular phenotypes. ANTHROPOID utilizes quantitative and state-of-the-art methods to explore exciting high-risk questions at multiple branches of the modern human lineage. This project is a ground breaking starting point to replay evolution and tackle the ancient question of what makes us uniquely human?

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The information about "ANTHROPOID" are provided by the European Opendata Portal: CORDIS opendata.

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