Opendata, web and dolomites

ANTHROPOID SIGNED

Great ape organoids to reconstruct uniquely human development

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 ANTHROPOID project word cloud

Explore the words cloud of the ANTHROPOID project. It provides you a very rough idea of what is the project "ANTHROPOID" about.

enhancer    questions    starting    chromatin    innovations    divergence    lineage    self    ancestors    functional    organ    comparisons    morphology    ancient    culture    metabolic    accessibility    dimensional    question    cellular    resolution    multiple    diverged    organisms    anthropoid    atlas    point    uniquely    transcriptomics    programs    altered    3d    cortex    human    risk    ground    stem    genomic    ape    cognitive    utilizes    endowed    ago    planet    chimpanzee    adaptive    cognition    cell    lack    recapitulate    closest    capacity    breaking    genetic    developmental    organoids    transcriptome    acquired    replay    small    dissect    humans    living    reshape    pluripotent    function    relatives    physiology    liver    enhanced    resurrect    colonize    tissues    complexity    biosphere    generate    metabolism    pscs    screens    chimpanzees    vision    neandertals    ancestralize    species    single    branches    intestine    apart    apes    million    tackle    modern    explore    evolution    phenotypes    difficult    entire    cells    evolutionary    quantitative    genome    organize   

Project "ANTHROPOID" data sheet

The following table provides information about the project.

Coordinator
INSTITUT FUR MOLEKULARE UND KLINISCHE OPHTHALMOLOGIE BASEL 

Organization address
address: C/O UNIVERSITÄTSSPITAL BASEL, AUGENKLINIK, MITTLERE STRASSE
city: BASEL
postcode: 4056
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-06-01   to  2024-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT FUR MOLEKULARE UND KLINISCHE OPHTHALMOLOGIE BASEL CH (BASEL) coordinator 1˙500˙000.00

Map

 Project objective

Humans diverged from our closest living relatives, chimpanzees and other great apes, 6-10 million years ago. Since this divergence, our ancestors acquired genetic changes that enhanced cognition, altered metabolism, and endowed our species with an adaptive capacity to colonize the entire planet and reshape the biosphere. Through genome comparisons between modern humans, Neandertals, chimpanzees and other apes we have identified genetic changes that likely contribute to innovations in human metabolic and cognitive physiology. However, it has been difficult to assess the functional effects of these genetic changes due to the lack of cell culture systems that recapitulate great ape organ complexity. Human and chimpanzee pluripotent stem cells (PSCs) can self-organize into three-dimensional (3D) tissues that recapitulate the morphology, function, and genetic programs controlling organ development. Our vision is to use organoids to study the changes that set modern humans apart from our closest evolutionary relatives as well as all other organisms on the planet. In ANTHROPOID we will generate a great ape developmental cell atlas using cortex, liver, and small intestine organoids. We will use single-cell transcriptomics and chromatin accessibility to identify cell type-specific features of transcriptome divergence at cellular resolution. We will dissect enhancer evolution using single-cell genomic screens and ancestralize human cells to resurrect pre-human cellular phenotypes. ANTHROPOID utilizes quantitative and state-of-the-art methods to explore exciting high-risk questions at multiple branches of the modern human lineage. This project is a ground breaking starting point to replay evolution and tackle the ancient question of what makes us uniquely human?

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "ANTHROPOID" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "ANTHROPOID" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

ENTRAPMENT (2019)

Septins: from bacterial entrapment to cellular immunity

Read More  

OSIRIS (2020)

Automatic measurement of speech understanding using EEG

Read More  

ORGANITRA (2019)

Transport of phosphorylated compounds across lipid bilayers by supramolecular receptors

Read More