Opendata, web and dolomites

ANTHROPOID SIGNED

Great ape organoids to reconstruct uniquely human development

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 ANTHROPOID project word cloud

Explore the words cloud of the ANTHROPOID project. It provides you a very rough idea of what is the project "ANTHROPOID" about.

point    metabolism    stem    transcriptome    liver    programs    resolution    intestine    modern    transcriptomics    cellular    apart    apes    single    self    pscs    endowed    chimpanzee    chromatin    ago    evolutionary    dimensional    questions    humans    capacity    tissues    ancestralize    uniquely    ancestors    entire    vision    species    divergence    relatives    ground    small    cognitive    breaking    question    developmental    screens    adaptive    living    functional    genome    multiple    acquired    innovations    pluripotent    organize    risk    culture    biosphere    genetic    lineage    cortex    morphology    explore    generate    utilizes    enhancer    quantitative    colonize    human    reshape    neandertals    metabolic    physiology    replay    recapitulate    cognition    3d    million    ancient    resurrect    chimpanzees    tackle    ape    accessibility    cell    comparisons    starting    organisms    evolution    phenotypes    closest    difficult    organ    organoids    genomic    complexity    anthropoid    altered    function    branches    atlas    dissect    enhanced    cells    planet    lack    diverged   

Project "ANTHROPOID" data sheet

The following table provides information about the project.

Coordinator
INSTITUT FUR MOLEKULARE UND KLINISCHE OPHTHALMOLOGIE BASEL 

Organization address
address: C/O UNIVERSITÄTSSPITAL BASEL, AUGENKLINIK, MITTLERE STRASSE
city: BASEL
postcode: 4056
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-06-01   to  2024-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT FUR MOLEKULARE UND KLINISCHE OPHTHALMOLOGIE BASEL CH (BASEL) coordinator 1˙500˙000.00

Map

 Project objective

Humans diverged from our closest living relatives, chimpanzees and other great apes, 6-10 million years ago. Since this divergence, our ancestors acquired genetic changes that enhanced cognition, altered metabolism, and endowed our species with an adaptive capacity to colonize the entire planet and reshape the biosphere. Through genome comparisons between modern humans, Neandertals, chimpanzees and other apes we have identified genetic changes that likely contribute to innovations in human metabolic and cognitive physiology. However, it has been difficult to assess the functional effects of these genetic changes due to the lack of cell culture systems that recapitulate great ape organ complexity. Human and chimpanzee pluripotent stem cells (PSCs) can self-organize into three-dimensional (3D) tissues that recapitulate the morphology, function, and genetic programs controlling organ development. Our vision is to use organoids to study the changes that set modern humans apart from our closest evolutionary relatives as well as all other organisms on the planet. In ANTHROPOID we will generate a great ape developmental cell atlas using cortex, liver, and small intestine organoids. We will use single-cell transcriptomics and chromatin accessibility to identify cell type-specific features of transcriptome divergence at cellular resolution. We will dissect enhancer evolution using single-cell genomic screens and ancestralize human cells to resurrect pre-human cellular phenotypes. ANTHROPOID utilizes quantitative and state-of-the-art methods to explore exciting high-risk questions at multiple branches of the modern human lineage. This project is a ground breaking starting point to replay evolution and tackle the ancient question of what makes us uniquely human?

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "ANTHROPOID" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "ANTHROPOID" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

CohoSing (2019)

Cohomology and Singularities

Read More  

FIRM (2019)

Form and Function of the Mitochondrial Retrograde Response

Read More  

TOROS (2019)

A Theory-Oriented Real-Time Operating System for Temporally Sound Cyber-Physical Systems

Read More