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Clockstop SIGNED

A Fast Throughput Drosophila Model to Identify Drug Treatments for Age-related Hearing Loss (ARHL)

Total Cost €


EC-Contrib. €






 Clockstop project word cloud

Explore the words cloud of the Clockstop project. It provides you a very rough idea of what is the project "Clockstop" about.

fruit    domain    expects    burden    hearing    innovation    ear    discovery    effort    core    compounds    children    million    interrelation    corresponding    nearly    social    human    trillion    societies    biotechnological    teams    industry    expedite    add    carries    global    preventing    respectively    speech    individual    900    paradigm    curing    ageing    powerful    drosophila    preliminary    summary    model    progress    fly    action    enterprise    age    act    vast    disabling    communicate    circadian    short    cohesion    db    auditory    ucl    exceed    suffer    full    world    max    threats    societal    tap    disease    us    health    40db    tool    forms    closely    bulk    biomedical    65    commercial    threatens    people    interact    erode    counter    pipeline    deafness    data    validate    abstract    pharma    crucially    arhl    gt    melanogaster    erc    characters    humans    experimental    drug    faster    organisation    aarhl    urgent    2050    adults    accelerated    monetary    devised   

Project "Clockstop" data sheet

The following table provides information about the project.


Organization address
city: LONDON
postcode: WC1E 6BT
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 0 €
 EC max contribution 150˙000 € (0%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-PoC
 Funding Scheme ERC-POC-LS
 Starting year 2019
 Duration (year-month-day) from 2019-06-01   to  2020-11-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY COLLEGE LONDON UK (LONDON) coordinator 150˙000.00


 Project objective

SHORT SUMMARY ABSTRACT (2,000 characters max.) The widespread increase in Hearing Loss is one of the major threats to future well-being in ageing human societies. The World Health Organisation (WHO) expects that by 2050 more than 900 million people will suffer from disabling hearing loss (i.e. a hearing loss >40dB in the better hearing ear for adults and >30 dB for children, respectively). The corresponding global cost is estimated to be more than US$ 1 trillion per year. The associated societal costs however - and costs to individual well-being – exceed the monetary domain. Hearing loss threatens to erode the very core of human social cohesion, namely their ability to communicate by speech. Within the various forms of hearing loss, Age-related Hearing Loss (ARHL) carries the vast bulk of the global disease burden. Nearly 1 out of every 3 people over the age of 65 is affected by disabling ARHL. Urgent action – and faster progress – is required. We here offer a novel way how to expedite this effort. Based on preliminary data generated in an ERC-funded project on the interrelation between the auditory and circadian system, we devised an accelerated model of Age-related Hearing Loss (aARHL) in the fruit fly Drosophila melanogaster. In this project we will (i) test, validate and apply the Drosophila aARHL model in order to identify novel compounds that can be used to counter-act ARHL in humans and (ii) add our novel experimental paradigm as a powerful new tool to the drug discovery pipeline dedicated to curing (or preventing) human deafness. Most crucially, we will closely interact with partners from pharma and biotechnological industry and the UCL Innovation & Enterprise teams, to tap the project’s full biomedical and commercial potential.

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The information about "CLOCKSTOP" are provided by the European Opendata Portal: CORDIS opendata.

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