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Clockstop SIGNED

A Fast Throughput Drosophila Model to Identify Drug Treatments for Age-related Hearing Loss (ARHL)

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 Clockstop project word cloud

Explore the words cloud of the Clockstop project. It provides you a very rough idea of what is the project "Clockstop" about.

adults    burden    max    paradigm    40db    bulk    deafness    corresponding    us    effort    faster    abstract    act    disabling    interrelation    humans    enterprise    circadian    aarhl    interact    counter    experimental    900    expedite    human    erc    ear    suffer    core    data    million    65    societies    threatens    biomedical    teams    commercial    age    domain    biotechnological    fruit    respectively    discovery    db    ageing    drug    innovation    pharma    characters    fly    threats    preliminary    cohesion    powerful    industry    model    urgent    communicate    global    speech    closely    hearing    trillion    organisation    accelerated    short    compounds    curing    summary    crucially    exceed    devised    vast    validate    people    erode    nearly    forms    pipeline    children    societal    carries    ucl    auditory    individual    action    health    add    arhl    melanogaster    disease    world    social    2050    gt    drosophila    tool    monetary    full    tap    preventing    expects    progress   

Project "Clockstop" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY COLLEGE LONDON 

Organization address
address: GOWER STREET
city: LONDON
postcode: WC1E 6BT
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 0 €
 EC max contribution 150˙000 € (0%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-PoC
 Funding Scheme ERC-POC-LS
 Starting year 2019
 Duration (year-month-day) from 2019-06-01   to  2020-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY COLLEGE LONDON UK (LONDON) coordinator 150˙000.00

Map

 Project objective

SHORT SUMMARY ABSTRACT (2,000 characters max.) The widespread increase in Hearing Loss is one of the major threats to future well-being in ageing human societies. The World Health Organisation (WHO) expects that by 2050 more than 900 million people will suffer from disabling hearing loss (i.e. a hearing loss >40dB in the better hearing ear for adults and >30 dB for children, respectively). The corresponding global cost is estimated to be more than US$ 1 trillion per year. The associated societal costs however - and costs to individual well-being – exceed the monetary domain. Hearing loss threatens to erode the very core of human social cohesion, namely their ability to communicate by speech. Within the various forms of hearing loss, Age-related Hearing Loss (ARHL) carries the vast bulk of the global disease burden. Nearly 1 out of every 3 people over the age of 65 is affected by disabling ARHL. Urgent action – and faster progress – is required. We here offer a novel way how to expedite this effort. Based on preliminary data generated in an ERC-funded project on the interrelation between the auditory and circadian system, we devised an accelerated model of Age-related Hearing Loss (aARHL) in the fruit fly Drosophila melanogaster. In this project we will (i) test, validate and apply the Drosophila aARHL model in order to identify novel compounds that can be used to counter-act ARHL in humans and (ii) add our novel experimental paradigm as a powerful new tool to the drug discovery pipeline dedicated to curing (or preventing) human deafness. Most crucially, we will closely interact with partners from pharma and biotechnological industry and the UCL Innovation & Enterprise teams, to tap the project’s full biomedical and commercial potential.

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The information about "CLOCKSTOP" are provided by the European Opendata Portal: CORDIS opendata.

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