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Clockstop SIGNED

A Fast Throughput Drosophila Model to Identify Drug Treatments for Age-related Hearing Loss (ARHL)

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 Clockstop project word cloud

Explore the words cloud of the Clockstop project. It provides you a very rough idea of what is the project "Clockstop" about.

biotechnological    deafness    short    preliminary    world    add    threats    experimental    validate    900    pipeline    forms    burden    innovation    human    melanogaster    act    monetary    curing    communicate    disease    drosophila    respectively    fruit    faster    interrelation    exceed    preventing    db    disabling    closely    biomedical    nearly    societies    ageing    interact    tool    teams    domain    aarhl    devised    trillion    children    industry    threatens    carries    ucl    fly    ear    accelerated    vast    bulk    erc    drug    expects    global    crucially    summary    circadian    data    arhl    characters    hearing    40db    discovery    individual    humans    corresponding    commercial    full    cohesion    2050    organisation    auditory    people    model    erode    expedite    effort    compounds    max    gt    adults    speech    action    65    social    progress    counter    societal    abstract    us    enterprise    powerful    health    paradigm    million    pharma    core    age    urgent    suffer    tap   

Project "Clockstop" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY COLLEGE LONDON 

Organization address
address: GOWER STREET
city: LONDON
postcode: WC1E 6BT
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 0 €
 EC max contribution 150˙000 € (0%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-PoC
 Funding Scheme ERC-POC-LS
 Starting year 2019
 Duration (year-month-day) from 2019-06-01   to  2020-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY COLLEGE LONDON UK (LONDON) coordinator 150˙000.00

Map

 Project objective

SHORT SUMMARY ABSTRACT (2,000 characters max.) The widespread increase in Hearing Loss is one of the major threats to future well-being in ageing human societies. The World Health Organisation (WHO) expects that by 2050 more than 900 million people will suffer from disabling hearing loss (i.e. a hearing loss >40dB in the better hearing ear for adults and >30 dB for children, respectively). The corresponding global cost is estimated to be more than US$ 1 trillion per year. The associated societal costs however - and costs to individual well-being – exceed the monetary domain. Hearing loss threatens to erode the very core of human social cohesion, namely their ability to communicate by speech. Within the various forms of hearing loss, Age-related Hearing Loss (ARHL) carries the vast bulk of the global disease burden. Nearly 1 out of every 3 people over the age of 65 is affected by disabling ARHL. Urgent action – and faster progress – is required. We here offer a novel way how to expedite this effort. Based on preliminary data generated in an ERC-funded project on the interrelation between the auditory and circadian system, we devised an accelerated model of Age-related Hearing Loss (aARHL) in the fruit fly Drosophila melanogaster. In this project we will (i) test, validate and apply the Drosophila aARHL model in order to identify novel compounds that can be used to counter-act ARHL in humans and (ii) add our novel experimental paradigm as a powerful new tool to the drug discovery pipeline dedicated to curing (or preventing) human deafness. Most crucially, we will closely interact with partners from pharma and biotechnological industry and the UCL Innovation & Enterprise teams, to tap the project’s full biomedical and commercial potential.

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The information about "CLOCKSTOP" are provided by the European Opendata Portal: CORDIS opendata.

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