His-Li mouse
His-Li mouse, the unique humanized mouse model resembling human liver and immune systems
Total Cost €
0EC-Contrib. €
0Partnership
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Project "His-Li mouse" data sheet
The following table provides information about the project.
| Coordinator |
TRANSCURE BIOSERVICES SAS
Organization address contact info |
| Coordinator Country | France [FR] |
| Project website | https://www.transcurebioservices.com/ |
| Total cost | 71˙429 € |
| EC max contribution | 50˙000 € (70%) |
| Programme |
1. H2020-EU.3. (PRIORITY 'Societal challenges) 2. H2020-EU.2.3. (INDUSTRIAL LEADERSHIP - Innovation In SMEs) 3. H2020-EU.2.1. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies) |
| Code Call | H2020-SMEInst-2018-2020-1 |
| Funding Scheme | SME-1 |
| Starting year | 2019 |
| Duration (year-month-day) | from 2019-06-01 to 2019-09-30 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | TRANSCURE BIOSERVICES SAS | FR (ARACHAMPS) | coordinator | 50˙000.00 |
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Project objective
Preclinical toxicology evaluation is the most critical step in pharmaceutical drug development, representing about 21.2% of the total drug development costs. About 70% of drug development programs fail due to toxicity or unexpected issues in Absorption, Distribution, Metabolism, and Excretion (ADME) at Phase 1 validation on humans. The main problem lies on the lack of accurate and reliable pre-clinical mouse models: in fact, current models fail to reflect human liver physiology, and often lead to the development of drugs that are safe in mice, and reveal unpredictably toxic or even deadly in humans. Strikingly, only 13.8% of drugs development programs are finally approved. The development of a single drug requires at least 1,000 iterations, accounting for about €10 M in total, and procedures that can take up to 10 years. TransCure bioServices offers the His-Li-mouse, a humanized mouse model for pre-clinical drug testing, based on the unique combination of the humanized liver and immune systems. His-Li-mouse is the first pre-clinical model that perfectly reflects the human liver physiology and immune response, thus representing a unique tool to perform reliable pre-clinical safety and efficacy tests of drugs. His-Li-mouse enables to reduce the failure rate observed when reaching the clinical trials and to subsequently eliminate unnecessary and costly experimental iterations. This will benefit to the global population, as a more efficient drug development process will potentially save millions of lives or improve its quality by enabling the faster discovery of breakthrough pharmaceuticals. During the phase 1 feasibility study, TransCure will establish a sound go-to-market strategy and supply chain, and will draft further development plans. During the innovation project, TransCure will optimise the humanization protocol, scale-up mice generation and validate the His-Li-mouse pre-clinical service with prospect customers.
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