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SSINGERG SIGNED

Solid-phase synthesis of imprinted nanoparticles exhibiting glycan epitope recognition in glycoproteins

Total Cost €

0

EC-Contrib. €

0

Partnership

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 SSINGERG project word cloud

Explore the words cloud of the SSINGERG project. It provides you a very rough idea of what is the project "SSINGERG" about.

limitations    subsequent    near    polymerization    preparation    outputs    reactor    ascertained    protocol    mixture    cell    supporting    behaving    nanoparticles    found    generate    exhibiting    automated    gel    reproducibility    glycoprotein    combined    imprinted    combinations    epitope    instrumentation    receptors    selectivity    size    acetlgalactosamine    temperature    prepared    critical    competitive    nanoreceptors    enrichment    optimum    protocols    patentable    filled    incubation    glycan    recognition    routes    mixtures    monosaccharides    sol    imprinting    containing    polymer    acetylglucosamine    sorption    cope    onto    silica    entities    nanomips    glycoproteins    isotherm    particles    beads    mannose    synthetic    binding    monosaccharide    criteriously    consisting    manner    immobilization    capacity    antibodies    setting    column    nanomip    specificity    phases    data    either    incorporated    standalone    subclasses    solid    play    affinity    glass    batch    glycoproteome    myriad    acetylgalactosamine    plastic    throughput    derive    screened    glyproteins    diseases    highest    immobilized    biology    solubility    synthesis    performance   

Project "SSINGERG" data sheet

The following table provides information about the project.

Coordinator
UNIVERSIDADE DO PORTO 

Organization address
address: PRACA GOMES TEIXEIRA
city: PORTO
postcode: 4099 002
website: http://www.up.pt

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Portugal [PT]
 Total cost 147˙815 €
 EC max contribution 147˙815 € (100%)
 Programme 1. H2020-EU.4. (SPREADING EXCELLENCE AND WIDENING PARTICIPATION)
 Code Call H2020-WF-01-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-10-01   to  2021-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSIDADE DO PORTO PT (PORTO) coordinator 147˙815.00

Map

 Project objective

The present project aims at the preparation of synthetic nanoreceptors exhibiting glycan epitope recognition in glycoproteins, identified to play a critical role in cell biology and diseases. Such nanoreceptors, behaving like antibodies, may cope with the current limitations in the essential step of enrichment of specific glycan subclasses, within studies of the glycoproteome. The preparation of the receptors will proceed through solid-phase synthesis of imprinted polymer nanoparticles, with the potential to deliver entities with size, specificity and solubility characteristics comparable to antibodies. The solid-phase synthesis of NanoMIP will require the immobilization of important monosaccharides (N-acetylglucosamine, N-acetlgalactosamine, mannose), widely found in glycoproteins, onto supporting beads. Several synthetic routes will be studied for the immobilization onto silica or plastic beads . In a reactor, built as a controlled temperature glass column filled with the beads containing immobilized monosaccharide, criteriously selected polymerization or sol-gel mixtures will generate the nanoMIPs, with subsequent selection of the highest affinity particles. The optimum combinations of solid-phase/imprinting protocol will be screened from a myriad of nanoMIPs prepared in different conditions. The performance of the nanoMIPs will be ascertained by setting a competitive enrichment protocol consisting of the incubation with a mixture of N-acetylglucosamine-, N-acetylgalactosamine- and mannose-containing glyproteins and a non-glycoprotein. Sorption isotherm data will be used to derive important binding features such as capacity, binding affinity and selectivity. Patentable robust solid-phases and imprinting protocols, either in standalone or combined manner, are planned outputs of the project, which may, in the near future, be incorporated into existing automated solid-phase synthesis instrumentation, for increased throughput and batch reproducibility.

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The information about "SSINGERG" are provided by the European Opendata Portal: CORDIS opendata.

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