Opendata, web and dolomites

SSINGERG SIGNED

Solid-phase synthesis of imprinted nanoparticles exhibiting glycan epitope recognition in glycoproteins

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 SSINGERG project word cloud

Explore the words cloud of the SSINGERG project. It provides you a very rough idea of what is the project "SSINGERG" about.

patentable    sol    standalone    found    protocols    sorption    data    incubation    solubility    combined    immobilization    setting    mixtures    reproducibility    derive    glass    acetylgalactosamine    polymerization    performance    gel    routes    exhibiting    particles    nanomips    optimum    synthesis    consisting    entities    glycan    silica    polymer    filled    cope    monosaccharide    isotherm    protocol    binding    glyproteins    specificity    near    beads    imprinted    instrumentation    phases    glycoprotein    nanomip    nanoparticles    cell    critical    biology    nanoreceptors    column    outputs    onto    incorporated    acetylglucosamine    containing    mixture    subsequent    enrichment    plastic    affinity    either    antibodies    subclasses    size    diseases    throughput    mannose    combinations    glycoproteins    receptors    highest    prepared    epitope    reactor    ascertained    play    immobilized    imprinting    acetlgalactosamine    screened    limitations    preparation    generate    competitive    myriad    supporting    criteriously    manner    automated    behaving    monosaccharides    recognition    synthetic    solid    selectivity    capacity    batch    temperature    glycoproteome   

Project "SSINGERG" data sheet

The following table provides information about the project.

Coordinator
UNIVERSIDADE DO PORTO 

Organization address
address: PRACA GOMES TEIXEIRA
city: PORTO
postcode: 4099 002
website: http://www.up.pt

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Portugal [PT]
 Total cost 147˙815 €
 EC max contribution 147˙815 € (100%)
 Programme 1. H2020-EU.4. (SPREADING EXCELLENCE AND WIDENING PARTICIPATION)
 Code Call H2020-WF-01-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-10-01   to  2021-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSIDADE DO PORTO PT (PORTO) coordinator 147˙815.00

Map

 Project objective

The present project aims at the preparation of synthetic nanoreceptors exhibiting glycan epitope recognition in glycoproteins, identified to play a critical role in cell biology and diseases. Such nanoreceptors, behaving like antibodies, may cope with the current limitations in the essential step of enrichment of specific glycan subclasses, within studies of the glycoproteome. The preparation of the receptors will proceed through solid-phase synthesis of imprinted polymer nanoparticles, with the potential to deliver entities with size, specificity and solubility characteristics comparable to antibodies. The solid-phase synthesis of NanoMIP will require the immobilization of important monosaccharides (N-acetylglucosamine, N-acetlgalactosamine, mannose), widely found in glycoproteins, onto supporting beads. Several synthetic routes will be studied for the immobilization onto silica or plastic beads . In a reactor, built as a controlled temperature glass column filled with the beads containing immobilized monosaccharide, criteriously selected polymerization or sol-gel mixtures will generate the nanoMIPs, with subsequent selection of the highest affinity particles. The optimum combinations of solid-phase/imprinting protocol will be screened from a myriad of nanoMIPs prepared in different conditions. The performance of the nanoMIPs will be ascertained by setting a competitive enrichment protocol consisting of the incubation with a mixture of N-acetylglucosamine-, N-acetylgalactosamine- and mannose-containing glyproteins and a non-glycoprotein. Sorption isotherm data will be used to derive important binding features such as capacity, binding affinity and selectivity. Patentable robust solid-phases and imprinting protocols, either in standalone or combined manner, are planned outputs of the project, which may, in the near future, be incorporated into existing automated solid-phase synthesis instrumentation, for increased throughput and batch reproducibility.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "SSINGERG" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "SSINGERG" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.4.)

LC-FMRI (2019)

Deciphering the effects of locus coeruleus activity on whole-brain dynamics and neurovascular coupling

Read More  

Human Jigsaw (2019)

The Human Jigsaw: Matching articulating skeletal elements from mass burials

Read More  

FAULT-LEARNING (2019)

Online Class Imbalance Learning for Fault Diagnosis of Critical Infrastructure Systems

Read More