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SSINGERG SIGNED

Solid-phase synthesis of imprinted nanoparticles exhibiting glycan epitope recognition in glycoproteins

Total Cost €

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EC-Contrib. €

0

Partnership

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 SSINGERG project word cloud

Explore the words cloud of the SSINGERG project. It provides you a very rough idea of what is the project "SSINGERG" about.

particles    combinations    antibodies    reactor    receptors    exhibiting    incorporated    nanomips    setting    glass    plastic    subsequent    epitope    derive    found    synthesis    sol    glyproteins    containing    incubation    silica    entities    enrichment    behaving    polymer    cell    routes    preparation    nanoreceptors    phases    combined    solid    temperature    acetlgalactosamine    column    binding    diseases    immobilized    outputs    either    generate    subclasses    solubility    batch    synthetic    mixture    standalone    selectivity    nanomip    myriad    prepared    optimum    data    imprinted    protocol    mannose    immobilization    beads    polymerization    throughput    screened    glycoproteome    sorption    monosaccharides    cope    glycoprotein    imprinting    nanoparticles    limitations    protocols    glycoproteins    near    automated    critical    affinity    glycan    play    size    reproducibility    mixtures    filled    isotherm    specificity    recognition    supporting    consisting    onto    gel    acetylglucosamine    criteriously    monosaccharide    acetylgalactosamine    ascertained    competitive    manner    capacity    instrumentation    biology    highest    performance    patentable   

Project "SSINGERG" data sheet

The following table provides information about the project.

Coordinator
UNIVERSIDADE DO PORTO 

Organization address
address: PRACA GOMES TEIXEIRA
city: PORTO
postcode: 4099 002
website: http://www.up.pt

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Portugal [PT]
 Total cost 147˙815 €
 EC max contribution 147˙815 € (100%)
 Programme 1. H2020-EU.4. (SPREADING EXCELLENCE AND WIDENING PARTICIPATION)
 Code Call H2020-WF-01-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-10-01   to  2021-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSIDADE DO PORTO PT (PORTO) coordinator 147˙815.00

Map

 Project objective

The present project aims at the preparation of synthetic nanoreceptors exhibiting glycan epitope recognition in glycoproteins, identified to play a critical role in cell biology and diseases. Such nanoreceptors, behaving like antibodies, may cope with the current limitations in the essential step of enrichment of specific glycan subclasses, within studies of the glycoproteome. The preparation of the receptors will proceed through solid-phase synthesis of imprinted polymer nanoparticles, with the potential to deliver entities with size, specificity and solubility characteristics comparable to antibodies. The solid-phase synthesis of NanoMIP will require the immobilization of important monosaccharides (N-acetylglucosamine, N-acetlgalactosamine, mannose), widely found in glycoproteins, onto supporting beads. Several synthetic routes will be studied for the immobilization onto silica or plastic beads . In a reactor, built as a controlled temperature glass column filled with the beads containing immobilized monosaccharide, criteriously selected polymerization or sol-gel mixtures will generate the nanoMIPs, with subsequent selection of the highest affinity particles. The optimum combinations of solid-phase/imprinting protocol will be screened from a myriad of nanoMIPs prepared in different conditions. The performance of the nanoMIPs will be ascertained by setting a competitive enrichment protocol consisting of the incubation with a mixture of N-acetylglucosamine-, N-acetylgalactosamine- and mannose-containing glyproteins and a non-glycoprotein. Sorption isotherm data will be used to derive important binding features such as capacity, binding affinity and selectivity. Patentable robust solid-phases and imprinting protocols, either in standalone or combined manner, are planned outputs of the project, which may, in the near future, be incorporated into existing automated solid-phase synthesis instrumentation, for increased throughput and batch reproducibility.

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The information about "SSINGERG" are provided by the European Opendata Portal: CORDIS opendata.

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