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DRmov SIGNED

Deciphering the RBPome in mosquitoes during virus infection

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 DRmov project word cloud

Explore the words cloud of the DRmov project. It provides you a very rough idea of what is the project "DRmov" about.

dramatically    host    persistence    compendium    denv    scientists    organisation    exhibit    health    group    dengue    treatment    global    potentially    interactome    risk    disrupted    therapies    decades    poorly    rnai    comprehensively    turning    ideal    performed    dynamics    infections    responsible    million    venezuelan    genome    broad    few    diseases    transmitting    replication    vector    encephalitic    disease    resistance    natural    ic    viruses    roles    toward    urged    world    viral    interests    edge    vectors    cutting    borne    rbps    despite    usually    zikv    envision    invertebrate    pathogens    zika    emerge    genes    rna    invasive    capture    cellular    yellow    antiviral    yfv    modified    expanded    mosquitoes    proteins    binding    genetically    fever    players    last    re    advisory    metabolism    equine    play    vulnerabilities    rbpome    efficacy    virus    spread    chkv    insecticides    countries    habitats    billion    inserted    insect    mosquito    virologists    spectrum    populations    chikungunya    profile    deaths    veev    aedes    infection   

Project "DRmov" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD 

Organization address
address: WELLINGTON SQUARE UNIVERSITY OFFICES
city: OXFORD
postcode: OX1 2JD
website: www.ox.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 224˙933 €
 EC max contribution 224˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2021-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD UK (OXFORD) coordinator 224˙933.00

Map

 Project objective

The impact of mosquito-borne diseases has expanded dramatically in the last few decades to become an emerging global health problem, with around 1 billion new infections and 1 million deaths each year. In Europe there are more than 20 countries with established populations of invasive Aedes mosquitoes. Aedes mosquitoes are the principle vectors responsible for transmitting high-risk pathogens such as ZIKA virus (ZIKV), dengue (DENV), yellow fever virus (YFV), chikungunya virus (CHKV) and Venezuelan equine encephalitic virus (VEEV). Despite our vulnerabilities to mosquito-borne diseases, virus replication dynamics is still poorly understood especially in the invertebrate vectors. No treatment against these viruses targeting essential viral proteins are currently available. Thus, the World Health Organisation (WHO) and its Vector Control Advisory Group has urged for insect vector control. Vector control is usually performed through insecticides; however, resistance can emerge in mosquitoes leading to persistence of the disease. Therefore, virologists are turning their interests toward host factors that play essential roles in infection as novel antiviral targets, since they can potentially exhibit broad-spectrum efficacy. In particular, scientists envision that genetically modified mosquitoes with disrupted genes required for infection can be re-inserted into natural habitats or through targeting these genes by RNAi in order to control viral spread. As all mosquito-borne viruses have RNA genome, cellular RNA-binding proteins (RBPs) emerge as ideal targets for antiviral therapies, as they are key players in cellular and viral RNA metabolism . Thus, we propose here to profile comprehensively the compendium of mosquito RBPs (RBPome) using RNA-interactome capture (RNA-IC). Furthermore, we will apply different cutting-edge methods to identify the role of mosquito RBPs during virus infection.

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The information about "DRMOV" are provided by the European Opendata Portal: CORDIS opendata.

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