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DRmov SIGNED

Deciphering the RBPome in mosquitoes during virus infection

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 DRmov project word cloud

Explore the words cloud of the DRmov project. It provides you a very rough idea of what is the project "DRmov" about.

re    group    scientists    natural    profile    advisory    treatment    ic    global    edge    countries    persistence    rbpome    infection    zikv    cellular    mosquitoes    despite    viral    responsible    dynamics    genome    expanded    play    usually    host    virus    antiviral    health    vector    risk    comprehensively    deaths    emerge    yellow    interests    resistance    ideal    compendium    broad    invasive    equine    denv    populations    infections    venezuelan    virologists    exhibit    mosquito    spectrum    pathogens    habitats    world    cutting    aedes    capture    last    fever    viruses    interactome    million    invertebrate    inserted    therapies    modified    replication    toward    disrupted    vulnerabilities    genes    metabolism    chikungunya    roles    proteins    envision    turning    organisation    zika    disease    potentially    rna    rbps    borne    few    insect    rnai    veev    efficacy    dramatically    dengue    insecticides    spread    performed    poorly    diseases    binding    transmitting    billion    yfv    decades    urged    vectors    genetically    chkv    players    encephalitic   

Project "DRmov" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD 

Organization address
address: WELLINGTON SQUARE UNIVERSITY OFFICES
city: OXFORD
postcode: OX1 2JD
website: www.ox.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 224˙933 €
 EC max contribution 224˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2021-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD UK (OXFORD) coordinator 224˙933.00

Map

 Project objective

The impact of mosquito-borne diseases has expanded dramatically in the last few decades to become an emerging global health problem, with around 1 billion new infections and 1 million deaths each year. In Europe there are more than 20 countries with established populations of invasive Aedes mosquitoes. Aedes mosquitoes are the principle vectors responsible for transmitting high-risk pathogens such as ZIKA virus (ZIKV), dengue (DENV), yellow fever virus (YFV), chikungunya virus (CHKV) and Venezuelan equine encephalitic virus (VEEV). Despite our vulnerabilities to mosquito-borne diseases, virus replication dynamics is still poorly understood especially in the invertebrate vectors. No treatment against these viruses targeting essential viral proteins are currently available. Thus, the World Health Organisation (WHO) and its Vector Control Advisory Group has urged for insect vector control. Vector control is usually performed through insecticides; however, resistance can emerge in mosquitoes leading to persistence of the disease. Therefore, virologists are turning their interests toward host factors that play essential roles in infection as novel antiviral targets, since they can potentially exhibit broad-spectrum efficacy. In particular, scientists envision that genetically modified mosquitoes with disrupted genes required for infection can be re-inserted into natural habitats or through targeting these genes by RNAi in order to control viral spread. As all mosquito-borne viruses have RNA genome, cellular RNA-binding proteins (RBPs) emerge as ideal targets for antiviral therapies, as they are key players in cellular and viral RNA metabolism . Thus, we propose here to profile comprehensively the compendium of mosquito RBPs (RBPome) using RNA-interactome capture (RNA-IC). Furthermore, we will apply different cutting-edge methods to identify the role of mosquito RBPs during virus infection.

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The information about "DRMOV" are provided by the European Opendata Portal: CORDIS opendata.

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