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DRmov SIGNED

Deciphering the RBPome in mosquitoes during virus infection

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 DRmov project word cloud

Explore the words cloud of the DRmov project. It provides you a very rough idea of what is the project "DRmov" about.

binding    scientists    billion    health    million    capture    rna    vector    turning    organisation    performed    populations    countries    host    broad    rbps    pathogens    group    mosquito    insect    rbpome    transmitting    poorly    equine    virologists    deaths    habitats    ideal    infections    inserted    encephalitic    usually    chikungunya    interactome    decades    potentially    genes    insecticides    invertebrate    cellular    few    dengue    last    veev    rnai    denv    despite    chkv    comprehensively    advisory    replication    diseases    envision    zikv    toward    vulnerabilities    spread    mosquitoes    aedes    spectrum    viral    borne    virus    persistence    ic    proteins    players    dramatically    dynamics    resistance    natural    world    compendium    zika    venezuelan    fever    yfv    metabolism    play    cutting    exhibit    antiviral    global    edge    emerge    roles    therapies    invasive    genetically    modified    genome    responsible    risk    viruses    vectors    interests    expanded    profile    infection    yellow    urged    treatment    efficacy    re    disrupted    disease   

Project "DRmov" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD 

Organization address
address: WELLINGTON SQUARE UNIVERSITY OFFICES
city: OXFORD
postcode: OX1 2JD
website: www.ox.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 224˙933 €
 EC max contribution 224˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2021-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD UK (OXFORD) coordinator 224˙933.00

Map

 Project objective

The impact of mosquito-borne diseases has expanded dramatically in the last few decades to become an emerging global health problem, with around 1 billion new infections and 1 million deaths each year. In Europe there are more than 20 countries with established populations of invasive Aedes mosquitoes. Aedes mosquitoes are the principle vectors responsible for transmitting high-risk pathogens such as ZIKA virus (ZIKV), dengue (DENV), yellow fever virus (YFV), chikungunya virus (CHKV) and Venezuelan equine encephalitic virus (VEEV). Despite our vulnerabilities to mosquito-borne diseases, virus replication dynamics is still poorly understood especially in the invertebrate vectors. No treatment against these viruses targeting essential viral proteins are currently available. Thus, the World Health Organisation (WHO) and its Vector Control Advisory Group has urged for insect vector control. Vector control is usually performed through insecticides; however, resistance can emerge in mosquitoes leading to persistence of the disease. Therefore, virologists are turning their interests toward host factors that play essential roles in infection as novel antiviral targets, since they can potentially exhibit broad-spectrum efficacy. In particular, scientists envision that genetically modified mosquitoes with disrupted genes required for infection can be re-inserted into natural habitats or through targeting these genes by RNAi in order to control viral spread. As all mosquito-borne viruses have RNA genome, cellular RNA-binding proteins (RBPs) emerge as ideal targets for antiviral therapies, as they are key players in cellular and viral RNA metabolism . Thus, we propose here to profile comprehensively the compendium of mosquito RBPs (RBPome) using RNA-interactome capture (RNA-IC). Furthermore, we will apply different cutting-edge methods to identify the role of mosquito RBPs during virus infection.

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The information about "DRMOV" are provided by the European Opendata Portal: CORDIS opendata.

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lastchecktime (2020-12-02 2:55:20) correctly updated