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DRmov SIGNED

Deciphering the RBPome in mosquitoes during virus infection

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 DRmov project word cloud

Explore the words cloud of the DRmov project. It provides you a very rough idea of what is the project "DRmov" about.

replication    proteins    persistence    infection    transmitting    turning    equine    spread    billion    aedes    treatment    invertebrate    venezuelan    cellular    decades    encephalitic    responsible    despite    inserted    zika    diseases    chkv    antiviral    natural    genome    metabolism    insecticides    chikungunya    deaths    modified    last    vectors    resistance    performed    scientists    interactome    genetically    play    envision    re    infections    populations    virologists    rbpome    comprehensively    mosquito    interests    cutting    yfv    broad    genes    countries    few    world    rnai    host    roles    vulnerabilities    million    compendium    risk    ideal    viruses    emerge    veev    profile    dynamics    yellow    capture    vector    advisory    virus    exhibit    edge    potentially    urged    dengue    mosquitoes    invasive    insect    toward    therapies    organisation    ic    binding    viral    health    borne    disease    zikv    usually    fever    rna    group    players    dramatically    expanded    spectrum    denv    global    disrupted    efficacy    habitats    pathogens    poorly    rbps   

Project "DRmov" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD 

Organization address
address: WELLINGTON SQUARE UNIVERSITY OFFICES
city: OXFORD
postcode: OX1 2JD
website: www.ox.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 224˙933 €
 EC max contribution 224˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2021-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD UK (OXFORD) coordinator 224˙933.00

Map

 Project objective

The impact of mosquito-borne diseases has expanded dramatically in the last few decades to become an emerging global health problem, with around 1 billion new infections and 1 million deaths each year. In Europe there are more than 20 countries with established populations of invasive Aedes mosquitoes. Aedes mosquitoes are the principle vectors responsible for transmitting high-risk pathogens such as ZIKA virus (ZIKV), dengue (DENV), yellow fever virus (YFV), chikungunya virus (CHKV) and Venezuelan equine encephalitic virus (VEEV). Despite our vulnerabilities to mosquito-borne diseases, virus replication dynamics is still poorly understood especially in the invertebrate vectors. No treatment against these viruses targeting essential viral proteins are currently available. Thus, the World Health Organisation (WHO) and its Vector Control Advisory Group has urged for insect vector control. Vector control is usually performed through insecticides; however, resistance can emerge in mosquitoes leading to persistence of the disease. Therefore, virologists are turning their interests toward host factors that play essential roles in infection as novel antiviral targets, since they can potentially exhibit broad-spectrum efficacy. In particular, scientists envision that genetically modified mosquitoes with disrupted genes required for infection can be re-inserted into natural habitats or through targeting these genes by RNAi in order to control viral spread. As all mosquito-borne viruses have RNA genome, cellular RNA-binding proteins (RBPs) emerge as ideal targets for antiviral therapies, as they are key players in cellular and viral RNA metabolism . Thus, we propose here to profile comprehensively the compendium of mosquito RBPs (RBPome) using RNA-interactome capture (RNA-IC). Furthermore, we will apply different cutting-edge methods to identify the role of mosquito RBPs during virus infection.

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The information about "DRMOV" are provided by the European Opendata Portal: CORDIS opendata.

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