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CiliaTubulinCode SIGNED

Self-organization of the cilium: the role of the tubulin code

Total Cost €

0

EC-Contrib. €

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Partnership

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 CiliaTubulinCode project word cloud

Explore the words cloud of the CiliaTubulinCode project. It provides you a very rough idea of what is the project "CiliaTubulinCode" about.

function    microtubules    enzymes    ideal    ptms    organization    specialized    machine    hypotheses    mediated    fluorescent    time    resolution    bidirectionality    regulating    question    understand    microtubule    intraflagellar    modifications    post    electron    signaling    generating    assays    suitable    respective    mutation    proteins    sufficient    motors    vitro    roles    ift    eukaryotic    cilia    techniques    transport    microscopy    assembly    respectively    exclusive    turn    direction    molecular    organizes    retrograde    encompassing    cells    plays    bidirectional    self    ptm    structures    shows    contributes    biochemical    tubules    cellular    motility    cilium    generally    dramatic    malfunction    lab    sophisticated    cryo    pathologies    complexes    differentiation    regulate    causes    imaging    code    structuring    functional    tomography    sensory    protein    structural    exists    atlas    anterograde    regulates    player    translational    adaptor    tubulin    answered    combine    functions    space   

Project "CiliaTubulinCode" data sheet

The following table provides information about the project.

Coordinator
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV 

Organization address
address: HOFGARTENSTRASSE 8
city: MUENCHEN
postcode: 80539
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙986˙406 €
 EC max contribution 1˙986˙406 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-COG
 Funding Scheme ERC-COG
 Starting year 2019
 Duration (year-month-day) from 2019-03-01   to  2024-02-29

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) coordinator 1˙986˙406.00

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 Project objective

This project aims at understanding of the role of the tubulin code for self-organization of complex microtubule based structures. Cilia turn out to be the ideal structures for the proposed research. A cilium is a sophisticated cellular machine that self-organizes from many protein complexes. It plays motility, sensory, and signaling roles in most eukaryotic cells, and its malfunction causes pathologies. The assembly of the cilium requires intraflagellar transport (IFT), a specialized bidirectional motility process that is mediated by adaptor proteins and direction specific molecular motors. Work from my lab shows that anterograde and retrograde IFT make exclusive use of the B-tubules and A-tubules, respectively. This insight answered a long standing question and shows that functional differentiation of tubules exists and is important for IFT. Tubulin post-translational modifications (PTMs) contribute to a tubulin code, making microtubules suitable for specific functions. Mutation of tubulin-PTM enzymes can have dramatic effects on cilia function and assembly. However, we do not understand of the role of tubulin-PTMs in cilia. Therefore, I propose to address the hypotheses that the tubulin code contributes to regulating bidirectional IFT motility, and more generally, that the tubulin code is a key player in structuring complex cellular assembly processes in space and time. This proposal aims at (i) understanding if tubulin-PTMs are necessary and/or sufficient to regulate the bidirectionality of IFT (ii) examining how the tubulin code regulates the assembly of cilia and (iii) generating a high-resolution atlas of tubulin-PTMs and their respective enzymes. We will combine advanced techniques encompassing state-of-the-art cryo-electron tomography, biochemical imaging, fluorescent microscopy, and in vitro assays to achieve molecular and structural understanding of the role of the tubulin code in the self-organization of cilia and of microtubule based cellular structures.

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The information about "CILIATUBULINCODE" are provided by the European Opendata Portal: CORDIS opendata.

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