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CiliaTubulinCode SIGNED

Self-organization of the cilium: the role of the tubulin code

Total Cost €

0

EC-Contrib. €

0

Partnership

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 CiliaTubulinCode project word cloud

Explore the words cloud of the CiliaTubulinCode project. It provides you a very rough idea of what is the project "CiliaTubulinCode" about.

malfunction    cells    imaging    assays    turn    exists    plays    structuring    mediated    organization    signaling    generating    sufficient    functions    organizes    electron    structures    player    microtubules    intraflagellar    translational    lab    microtubule    regulating    machine    respective    tubules    mutation    space    function    respectively    sensory    cilia    generally    dramatic    direction    hypotheses    cryo    techniques    post    tubulin    complexes    regulate    ptm    differentiation    pathologies    answered    ptms    shows    question    adaptor    microscopy    molecular    transport    anterograde    contributes    ift    assembly    motors    retrograde    fluorescent    ideal    cilium    functional    bidirectional    self    sophisticated    code    causes    regulates    combine    enzymes    suitable    roles    motility    time    encompassing    atlas    biochemical    proteins    resolution    understand    bidirectionality    structural    tomography    exclusive    cellular    vitro    specialized    modifications    protein    eukaryotic   

Project "CiliaTubulinCode" data sheet

The following table provides information about the project.

Coordinator
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV 

Organization address
address: HOFGARTENSTRASSE 8
city: MUENCHEN
postcode: 80539
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙986˙406 €
 EC max contribution 1˙986˙406 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-COG
 Funding Scheme ERC-COG
 Starting year 2019
 Duration (year-month-day) from 2019-03-01   to  2024-02-29

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) coordinator 1˙986˙406.00

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 Project objective

This project aims at understanding of the role of the tubulin code for self-organization of complex microtubule based structures. Cilia turn out to be the ideal structures for the proposed research. A cilium is a sophisticated cellular machine that self-organizes from many protein complexes. It plays motility, sensory, and signaling roles in most eukaryotic cells, and its malfunction causes pathologies. The assembly of the cilium requires intraflagellar transport (IFT), a specialized bidirectional motility process that is mediated by adaptor proteins and direction specific molecular motors. Work from my lab shows that anterograde and retrograde IFT make exclusive use of the B-tubules and A-tubules, respectively. This insight answered a long standing question and shows that functional differentiation of tubules exists and is important for IFT. Tubulin post-translational modifications (PTMs) contribute to a tubulin code, making microtubules suitable for specific functions. Mutation of tubulin-PTM enzymes can have dramatic effects on cilia function and assembly. However, we do not understand of the role of tubulin-PTMs in cilia. Therefore, I propose to address the hypotheses that the tubulin code contributes to regulating bidirectional IFT motility, and more generally, that the tubulin code is a key player in structuring complex cellular assembly processes in space and time. This proposal aims at (i) understanding if tubulin-PTMs are necessary and/or sufficient to regulate the bidirectionality of IFT (ii) examining how the tubulin code regulates the assembly of cilia and (iii) generating a high-resolution atlas of tubulin-PTMs and their respective enzymes. We will combine advanced techniques encompassing state-of-the-art cryo-electron tomography, biochemical imaging, fluorescent microscopy, and in vitro assays to achieve molecular and structural understanding of the role of the tubulin code in the self-organization of cilia and of microtubule based cellular structures.

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The information about "CILIATUBULINCODE" are provided by the European Opendata Portal: CORDIS opendata.

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