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Role of endocycle in Acute Kidney Injury Response and Chronic Kidney Disease development

Total Cost €


EC-Contrib. €






 ROAR project word cloud

Explore the words cloud of the ROAR project. It provides you a very rough idea of what is the project "ROAR" about.

techniques    transgenic    variants    progression    endocycles    function    collectively    recovery    pathogenesis    epithelial    cytokinesis    tubular    view    injury    death    phases    animal    first    episodes    preliminary    drive    unexplored    chronic    capacity    acute    unclear    totally    functional    time    deaths    suggested    phenomenon    unknown    drives    enter    pathophysiological    yap1    reversible    physiologic    risk    re    subsequent    contributes    million    critical    vitro    mammalian    lineage    repair    human    tissues    basis    endocycle    fucci2ar    describe    lethal    global    disease    repeatedly    health    carry    primary    experiments    cycle    mostly    cells    entirely    tracing    relevance    mild    structured    mechanism    tissue    reporter    public    ckd    regenerative    alone    mediated    kidney    aki    damage    models    outcomes    consisting    nevertheless    tecs    cell    remnant    cultures    data    substantial    renal    attributed   

Project "ROAR" data sheet

The following table provides information about the project.


Organization address
address: Piazza San Marco 4
city: Florence
postcode: 50121

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 171˙473 €
 EC max contribution 171˙473 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2019
 Duration (year-month-day) from 2019-09-01   to  2021-08-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITA DEGLI STUDI DI FIRENZE IT (Florence) coordinator 171˙473.00


 Project objective

Acute kidney injury (AKI) is a global public health concern which results in 1.7 million deaths per year. If not lethal in the acute phase, AKI is considered reversible as suggested by recovery of renal function. However, even mild AKI episodes carry substantial risk of developing subsequent chronic kidney disease (CKD). The pathophysiological basis for this phenomenon remains unclear. Injury and death of tubular cells are recognized as the main factors in the pathogenesis of AKI and functional recovery from AKI was traditionally attributed to the regenerative capacity of tubular epithelial cells (TECs) which are believed to re-enter the cell cycle and repair the damage. Nevertheless, my preliminary data provide evidence that an endocycle-mediated response of remnant TECs may represent a critical mechanism of response to AKI. Endocycles are cell cycle variants consisting of G and S phases alone that repeatedly proceed without cytokinesis and its role in repair of mammalian tissues is mostly unknown and totally unexplored in the kidney. This proposal will be structured into 3 distinct objectives to address: 1. The physiologic relevance of endocycle for kidney function recovery after AKI 2. The role of endocycle in the progression of AKI to CKD; 3. The mechanism by which YAP1 drives endocycle and contributes to CKD development. To this end I will use lineage tracing techniques based on the FUCCI2aR reporter applied in different transgenic animal models of AKI, together with in vitro experiments in human primary cultures of renal tubular cells. Collectively, the outcomes of this proposal are expected to provide an entirely novel view of the kidney’s response to AKI, to further our understanding of the processes that drive CKD following AKI, as well as to describe for the first time endocycle as a critical response mechanism to tissue injury in the mammalian kidney.

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The information about "ROAR" are provided by the European Opendata Portal: CORDIS opendata.

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