Explore the words cloud of the ROAR project. It provides you a very rough idea of what is the project "ROAR" about.
The following table provides information about the project.
UNIVERSITA DEGLI STUDI DI FIRENZE
|Coordinator Country||Italy [IT]|
|Total cost||171˙473 €|
|EC max contribution||171˙473 € (100%)|
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
|Duration (year-month-day)||from 2019-09-01 to 2021-08-31|
Take a look of project's partnership.
|1||UNIVERSITA DEGLI STUDI DI FIRENZE||IT (Florence)||coordinator||171˙473.00|
Acute kidney injury (AKI) is a global public health concern which results in 1.7 million deaths per year. If not lethal in the acute phase, AKI is considered reversible as suggested by recovery of renal function. However, even mild AKI episodes carry substantial risk of developing subsequent chronic kidney disease (CKD). The pathophysiological basis for this phenomenon remains unclear. Injury and death of tubular cells are recognized as the main factors in the pathogenesis of AKI and functional recovery from AKI was traditionally attributed to the regenerative capacity of tubular epithelial cells (TECs) which are believed to re-enter the cell cycle and repair the damage. Nevertheless, my preliminary data provide evidence that an endocycle-mediated response of remnant TECs may represent a critical mechanism of response to AKI. Endocycles are cell cycle variants consisting of G and S phases alone that repeatedly proceed without cytokinesis and its role in repair of mammalian tissues is mostly unknown and totally unexplored in the kidney. This proposal will be structured into 3 distinct objectives to address: 1. The physiologic relevance of endocycle for kidney function recovery after AKI 2. The role of endocycle in the progression of AKI to CKD; 3. The mechanism by which YAP1 drives endocycle and contributes to CKD development. To this end I will use lineage tracing techniques based on the FUCCI2aR reporter applied in different transgenic animal models of AKI, together with in vitro experiments in human primary cultures of renal tubular cells. Collectively, the outcomes of this proposal are expected to provide an entirely novel view of the kidney’s response to AKI, to further our understanding of the processes that drive CKD following AKI, as well as to describe for the first time endocycle as a critical response mechanism to tissue injury in the mammalian kidney.
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "ROAR" project.
For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.
Send me an email (email@example.com) and I put them in your project's page as son as possible.
Thanks. And then put a link of this page into your project's website.
The information about "ROAR" are provided by the European Opendata Portal: CORDIS opendata.
The PIDE and Portuguese Society under the Salazar Dictatorship 1945-1974: Fear, Self-Policing, Accommodation.Read More
Communists into Liberals: The Transformation and Demise of the Left as Precursor to the Illiberal Turn in PolandRead More
The impact of 'free' digital offers on individual behavior and its implications for consumer and data protection lawsRead More