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SchiSTOP SIGNED

Beyond mass drug administration: understanding Schistosomiasis dynamics to STOP transmission

Total Cost €

EC-Contrib. €

Partnership

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SchiSTOP project word cloud

Explore the words cloud of the SchiSTOP project. It provides you a very rough idea of what is the project "SchiSTOP" about.

asia reduce group ways 5 mechanisms mass met le people neglected elimination simulate proposing infectious epidemiology intensive parasite sake dynamics move schistosomiasis children ntds reference administration genetics framework moderate gain mathematical ntd individual unlikely mda heavy income erasmus insights infections vlas 280 immunology models subtropical school diverse transmission tropical underlying poverty methodological comprehensively prevalence strategies biannual rebound region proven world 2020 round organization edge aged african health model poorly cutting de killing populations rapid ibm secondment americas intensity prof dr africa alone university poppy sdg diagnostics prevalent stochastic diseases priorities deadliest drug seems optimal integrating statistical global mc glasgow lamberton

Project "SchiSTOP" data sheet

The following table provides information about the project.

Coordinator	ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM Organization address address: DR MOLEWATERPLEIN 40 city: ROTTERDAM postcode: 3015 GD website: www.erasmusmc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Netherlands [NL]
Total cost	175˙572 €
EC max contribution	175˙572 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2018
Funding Scheme	MSCA-IF-EF-ST
Starting year	2020
Duration (year-month-day)	from 2020-09-01 to 2022-08-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM Organization address address: DR MOLEWATERPLEIN 40 city: ROTTERDAM postcode: 3015 GD website: www.erasmusmc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (ROTTERDAM)	coordinator	175˙572.00

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Project objective

Neglected tropical diseases (NTDs) are a diverse group of infections which are especially prevalent in low-income populations in tropical and subtropical areas in Africa, Asia and the Americas. Schistosomiasis is the deadliest NTD killing an estimated 280,000 people each year in the African region alone. The World Health Organization (WHO) 2020 target for schistosomiasis is to reduce the prevalence of heavy-intensity infections to ≤5% among school-aged children through Mass Drug Administration (MDA). However, in areas of moderate and high prevalence the goal seems unlikely to be met as even with intensive biannual MDA, prevalence of infections are still seen to rebound rapidly after each round. The reasons are still poorly understood. Mathematical models and statistical methods have proven to be essential to gain insights into the complex processes underlying the transmission dynamics of infectious diseases. In this research project, I will develop a stochastic individual-based model (IBM) to simulate schistosomiasis transmission integrating cutting-edge mathematical models and statistical methods with recent advances in parasite genetics, epidemiology, diagnostics and immunology. This project aims to advance our current understanding of schistosomiasis transmission dynamics investigating the mechanisms that cause the rapid rebound of prevalence after MDA and proposing optimal implementation of current and novel strategies to achieve schistosomiasis control and move towards elimination. In addition, this project will build a reference methodological framework to comprehensively study other MDA targeted infectious diseases. The proposed project addresses one of the priorities of the EU, through global poverty reduction (SDG goal 1) by promoting ways of improving future health (SDG goal 3).This project will be carried out at Erasmus MC with Prof. Sake J. de Vlas and at University of Glasgow (secondment) with Dr. Poppy Lamberton.

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The information about "SCHISTOP" are provided by the European Opendata Portal: CORDIS opendata.