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Specific Fluorogenic Peptides for Imaging Metastasis-associated Macrophages

Total Cost €


EC-Contrib. €






 MACROIMAGING project word cloud

Explore the words cloud of the MACROIMAGING project. It provides you a very rough idea of what is the project "MACROIMAGING" about.

cell    showing    probes    abundant    theranostics    macrophage    metastatic    populations    governed    fate    optimisation    first    supply    microenvironment    lack    protein    understand    recruitment    disulfide    technologies    thermodynamics    cuaac    methodology    click    confirmed    cells    report    libraries    preparation    dcc    innovative    individual    persistent    chemical    cd11b    depletion    recruited    reversible    interdisciplinary    macrophages    imaging    discovery    progress    cyclic    fluorophores    tools    cancer    receptors    elusive    biology    bonds    knockouts    size    conjugation    fluorogenic    mainly    tumours    nutshell    endocytosis    receptor    affinity    vivo    generation    amplify    technique    drug    selectivity    metastasing    tumour    metastasis    vitro    fluoromacs    reduces    macroimaging    dynamic    selective    localisation    mediated    tetrapeptides    enormous    suggesting    peptides    recognition    encompassing    normal    generate    combinatorial    chemistry    cohorts    tm   

Project "MACROIMAGING" data sheet

The following table provides information about the project.


Organization address
postcode: EH8 9YL

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-10-01   to  2017-09-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF EDINBURGH UK (EDINBURGH) coordinator 183˙454.00


 Project objective

MACROIMAGING is a highly interdisciplinary project encompassing the preparation and optimisation of innovative fluorogenic imaging tools with high selectivity for metastasis-associated macrophages. The metastatic potential of tumours is defined by the tumour microenvironment (TM), where macrophages are the most abundant cells. However, the role of macrophages in the TM remains elusive mainly because of the lack of technologies to target these unique populations of cells in vivo. CD11b metastasis-associated macrophages are recruited by metastasing cancer cells. Their depletion reduces the number and size of metastasis, suggesting that their recruitment is essential for persistent growth of cancer cells. However, there is a need for imaging tools that report the localisation and cell fate of these macrophages to understand how they help tumour cells to progress in the TM. By means of Dynamic Combinatorial Chemistry, libraries of cyclic peptides will be generated from individual tetrapeptides through reversible disulfide bonds. Governed by thermodynamics, DCC will amplify cyclic peptides showing high affinity for CD11b macrophage receptors, involved in the development of metastasis. This technique will supply specific cyclic peptides targeting CD11b. Click chemistry (i.e. CuAAC) will allow the conjugation of these peptides to macrophage-specific fluorophores to generate FLUOROMACS. FLUOROMACS will enable selective imaging of CD11b macrophages by means of receptor-mediated endocytosis. Selectivity will be confirmed in vitro using macrophages from normal cohorts and knockouts. Finally Fluoromacs will be optimised as in vivo imaging probes for metastasis-associated macrophages. In a nutshell, MACROIMAGING will provide the first generation of chemical probes for imaging metastasis-associated macrophages in vivo. This methodology will also have enormous impact in other areas of chemical biology, such as protein recognition, drug discovery and theranostics.


year authors and title journal last update
List of publications.
2017 Ramon Subiros-Funosas, Lorena Mendive-Tapia, Jesus Sot, John D. Pound, Nicole Barth, Yaiza Varela, Felix M. Goñi, Margaret Paterson, Christopher D. Gregory, Fernando Albericio, Ian Dransfield, Rodolfo Lavilla, Marc Vendrell
A Trp-BODIPY cyclic peptide for fluorescence labelling of apoptotic bodies
published pages: 945-948, ISSN: 1359-7345, DOI: 10.1039/C6CC07879F
Chem. Commun. 53/5 2019-06-17
2017 Antonio Fernandez, Matthieu Vermeren, Duncan Humphries, Ramon Subiros-Funosas, Nicole Barth, Lara Campana, Alison MacKinnon, Yi Feng, Marc Vendrell
Chemical Modulation of in Vivo Macrophage Function with Subpopulation-Specific Fluorescent Prodrug Conjugates
published pages: 995-1005, ISSN: 2374-7943, DOI: 10.1021/acscentsci.7b00262
ACS Central Science 3/9 2019-06-17
2017 Lorena Mendive-Tapia, Ramon Subiros-Funosas, Can Zhao, Fernando Albericio, Nick D Read, Rodolfo Lavilla, Marc Vendrell
Preparation of a Trp-BODIPY fluorogenic amino acid to label peptides for enhanced live-cell fluorescence imaging
published pages: 1588-1619, ISSN: 1754-2189, DOI: 10.1038/nprot.2017.048
Nature Protocols 12/8 2019-06-17

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