Opendata, web and dolomites

MACROIMAGING SIGNED

Specific Fluorogenic Peptides for Imaging Metastasis-associated Macrophages

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 MACROIMAGING project word cloud

Explore the words cloud of the MACROIMAGING project. It provides you a very rough idea of what is the project "MACROIMAGING" about.

macroimaging    showing    receptor    metastasing    reversible    combinatorial    first    individual    imaging    innovative    dcc    libraries    elusive    reduces    thermodynamics    interdisciplinary    amplify    governed    fluorogenic    cd11b    technologies    generate    supply    populations    protein    macrophages    discovery    generation    methodology    progress    bonds    drug    knockouts    mainly    localisation    vitro    selectivity    tumour    theranostics    biology    enormous    abundant    affinity    fate    receptors    selective    conjugation    peptides    tm    depletion    tetrapeptides    disulfide    fluorophores    cancer    endocytosis    metastasis    cell    cells    recruited    normal    understand    cyclic    suggesting    preparation    microenvironment    lack    metastatic    encompassing    report    persistent    chemical    technique    recognition    optimisation    fluoromacs    click    vivo    cuaac    macrophage    recruitment    dynamic    tools    tumours    probes    size    cohorts    nutshell    chemistry    mediated    confirmed   

Project "MACROIMAGING" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF EDINBURGH 

Organization address
address: OLD COLLEGE, SOUTH BRIDGE
city: EDINBURGH
postcode: EH8 9YL
website: www.ed.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website http://www.dynafluors.co.uk
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-10-01   to  2017-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF EDINBURGH UK (EDINBURGH) coordinator 183˙454.00

Map

 Project objective

MACROIMAGING is a highly interdisciplinary project encompassing the preparation and optimisation of innovative fluorogenic imaging tools with high selectivity for metastasis-associated macrophages. The metastatic potential of tumours is defined by the tumour microenvironment (TM), where macrophages are the most abundant cells. However, the role of macrophages in the TM remains elusive mainly because of the lack of technologies to target these unique populations of cells in vivo. CD11b metastasis-associated macrophages are recruited by metastasing cancer cells. Their depletion reduces the number and size of metastasis, suggesting that their recruitment is essential for persistent growth of cancer cells. However, there is a need for imaging tools that report the localisation and cell fate of these macrophages to understand how they help tumour cells to progress in the TM. By means of Dynamic Combinatorial Chemistry, libraries of cyclic peptides will be generated from individual tetrapeptides through reversible disulfide bonds. Governed by thermodynamics, DCC will amplify cyclic peptides showing high affinity for CD11b macrophage receptors, involved in the development of metastasis. This technique will supply specific cyclic peptides targeting CD11b. Click chemistry (i.e. CuAAC) will allow the conjugation of these peptides to macrophage-specific fluorophores to generate FLUOROMACS. FLUOROMACS will enable selective imaging of CD11b macrophages by means of receptor-mediated endocytosis. Selectivity will be confirmed in vitro using macrophages from normal cohorts and knockouts. Finally Fluoromacs will be optimised as in vivo imaging probes for metastasis-associated macrophages. In a nutshell, MACROIMAGING will provide the first generation of chemical probes for imaging metastasis-associated macrophages in vivo. This methodology will also have enormous impact in other areas of chemical biology, such as protein recognition, drug discovery and theranostics.

 Publications

year authors and title journal last update
List of publications.
2017 Ramon Subiros-Funosas, Lorena Mendive-Tapia, Jesus Sot, John D. Pound, Nicole Barth, Yaiza Varela, Felix M. Goñi, Margaret Paterson, Christopher D. Gregory, Fernando Albericio, Ian Dransfield, Rodolfo Lavilla, Marc Vendrell
A Trp-BODIPY cyclic peptide for fluorescence labelling of apoptotic bodies
published pages: 945-948, ISSN: 1359-7345, DOI: 10.1039/C6CC07879F
Chem. Commun. 53/5 2019-06-17
2017 Antonio Fernandez, Matthieu Vermeren, Duncan Humphries, Ramon Subiros-Funosas, Nicole Barth, Lara Campana, Alison MacKinnon, Yi Feng, Marc Vendrell
Chemical Modulation of in Vivo Macrophage Function with Subpopulation-Specific Fluorescent Prodrug Conjugates
published pages: 995-1005, ISSN: 2374-7943, DOI: 10.1021/acscentsci.7b00262
ACS Central Science 3/9 2019-06-17
2017 Lorena Mendive-Tapia, Ramon Subiros-Funosas, Can Zhao, Fernando Albericio, Nick D Read, Rodolfo Lavilla, Marc Vendrell
Preparation of a Trp-BODIPY fluorogenic amino acid to label peptides for enhanced live-cell fluorescence imaging
published pages: 1588-1619, ISSN: 1754-2189, DOI: 10.1038/nprot.2017.048
Nature Protocols 12/8 2019-06-17

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "MACROIMAGING" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "MACROIMAGING" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

Widow Spider Mating (2020)

Immature mating as a novel tactic of an invasive widow spider

Read More  

TARGET SLEEP (2020)

Boosting motor learning through sleep and targeted memory reactivation in ageing and Parkinson’s disease

Read More  

GLORIOUS (2019)

Digital Poetry in Today’s Russia: Canonisation and Translation

Read More