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MOVEMeNt SIGNED

Decoding alpha motor neurons diversity and selective vulnerability to disease

Total Cost €

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EC-Contrib. €

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Partnership

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 MOVEMeNt project word cloud

Explore the words cloud of the MOVEMeNt project. It provides you a very rough idea of what is the project "MOVEMeNt" about.

ffr    fatigable    molecular    class    strategies    adult    subtypes    intoxication    mice    retrograde    overreaching    sbma    fast    cell    undertaking    substrate    muscular    achievement    disease    mouse    aim2    terminal    candidate    genes    atrophy    compensation    selectively    purify    motor    solid    roadmap    nuclei    neuronal    harvard    diseases    sprouting    differentially    mechanisms    university    transcriptional    clinically    lateral    broadly    amyotrophic    sfr    gap    spinal    identity    neurons    analyze    classes    denervation    generating    technologies    normally    facs    therapeutic    single    functional    cords    markers    degenerating    degenerates    amns    amn    return    successful    reveal    als    movement    neurotoxin    logics    therapy    pinpointing    harmonically    transcriptomic    critical    host    filling    integrate    remodeling    roles    vulnerable    pioneered    mns    skills    first    candidates    alpha    population    background    sclerosis    dissecting    suptype    underlying    expression    fingerprints    ff    shape    degenerate    playing    bulbar    vulnerability    isolate    vivo    insult    selective    resistant    rate    neuromuscular    function    labeling   

Project "MOVEMeNt" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITA DEGLI STUDI DI PADOVA 

Organization address
address: VIA 8 FEBBRAIO 2
city: PADOVA
postcode: 35122
website: www.unipd.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 183˙473 €
 EC max contribution 183˙473 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2020
 Duration (year-month-day) from 2020-02-01   to  2022-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITA DEGLI STUDI DI PADOVA IT (PADOVA) coordinator 183˙473.00

Map

 Project objective

Alpha motor neurons (aMN) are a clinically relevant neuronal population that selectively degenerates in neuromuscular diseases, including amyotrophic lateral sclerosis (ALS) and spinal bulbar muscular atrophy (SBMA). Distinct classes of aMNs (SFR, FFR and FF) degenerate at different rate in these diseases, with the fast fatigable (FF) MNs degenerating first. The molecular mechanisms underlying this selective vulnerability are only partially known. Understanding the molecular logics that shape the identity and function of aMN subtypes in vivo is directly relevant to the development of novel therapeutic strategies. Here I propose to harmonically integrate my solid background in dissecting the molecular fingerprints of distinct neuronal subtypes in adult mice by undertaking new technologies I pioneered at Harvard University, with new skills and knowledge I will build at the Host Institution, which will be critical for the successful achievement of my goal. The overreaching goal of MOVEMeNt is to identify the molecular substrate of disease vulnerability in aMNs. I will (Aim 1) isolate and FACS-purify aMN-nuclei from adult mouse spinal cords, based on the specific expression of aMN markers. Single cell transcriptomic analysis will reveal class-specific molecular fingerprints, including factors playing key roles in suptype-specific development, function, and disease vulnerability. I will also (Aim2) analyze the transcriptional changes of differentially vulnerable aMN classes upon retrograde labeling and functional denervation by neurotoxin intoxication. This work will return candidate genes directly controlling terminal sprouting and remodeling, critical steps that disease-resistant aMN subtypes normally undertake for neuronal loss compensation upon insult. More broadly, I aim to contribute in filling an important knowledge gap by generating the first transcriptomic roadmap of aMN subtypes, and pinpointing at new candidates for therapy development.

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The information about "MOVEMENT" are provided by the European Opendata Portal: CORDIS opendata.

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