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MOVEMeNt SIGNED

Decoding alpha motor neurons diversity and selective vulnerability to disease

Total Cost €

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EC-Contrib. €

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Partnership

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 MOVEMeNt project word cloud

Explore the words cloud of the MOVEMeNt project. It provides you a very rough idea of what is the project "MOVEMeNt" about.

logics    shape    bulbar    ffr    neurotoxin    amns    remodeling    identity    pioneered    achievement    intoxication    markers    facs    isolate    amyotrophic    degenerates    skills    rate    selective    retrograde    broadly    adult    functional    transcriptomic    sbma    nuclei    function    university    alpha    neurons    labeling    undertaking    overreaching    amn    sfr    strategies    transcriptional    first    filling    fingerprints    candidates    mechanisms    denervation    playing    suptype    terminal    single    background    diseases    roles    movement    degenerating    differentially    host    underlying    subtypes    successful    vulnerable    aim2    atrophy    mouse    solid    degenerate    molecular    genes    return    sprouting    pinpointing    purify    normally    disease    mice    critical    gap    spinal    vivo    harvard    sclerosis    candidate    mns    neuronal    compensation    insult    neuromuscular    therapy    ff    motor    clinically    analyze    vulnerability    therapeutic    population    muscular    dissecting    integrate    class    reveal    roadmap    selectively    technologies    resistant    classes    cords    fatigable    cell    lateral    expression    generating    harmonically    substrate    als    fast   

Project "MOVEMeNt" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITA DEGLI STUDI DI PADOVA 

Organization address
address: VIA 8 FEBBRAIO 2
city: PADOVA
postcode: 35122
website: www.unipd.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 183˙473 €
 EC max contribution 183˙473 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2020
 Duration (year-month-day) from 2020-02-01   to  2022-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITA DEGLI STUDI DI PADOVA IT (PADOVA) coordinator 183˙473.00

Map

 Project objective

Alpha motor neurons (aMN) are a clinically relevant neuronal population that selectively degenerates in neuromuscular diseases, including amyotrophic lateral sclerosis (ALS) and spinal bulbar muscular atrophy (SBMA). Distinct classes of aMNs (SFR, FFR and FF) degenerate at different rate in these diseases, with the fast fatigable (FF) MNs degenerating first. The molecular mechanisms underlying this selective vulnerability are only partially known. Understanding the molecular logics that shape the identity and function of aMN subtypes in vivo is directly relevant to the development of novel therapeutic strategies. Here I propose to harmonically integrate my solid background in dissecting the molecular fingerprints of distinct neuronal subtypes in adult mice by undertaking new technologies I pioneered at Harvard University, with new skills and knowledge I will build at the Host Institution, which will be critical for the successful achievement of my goal. The overreaching goal of MOVEMeNt is to identify the molecular substrate of disease vulnerability in aMNs. I will (Aim 1) isolate and FACS-purify aMN-nuclei from adult mouse spinal cords, based on the specific expression of aMN markers. Single cell transcriptomic analysis will reveal class-specific molecular fingerprints, including factors playing key roles in suptype-specific development, function, and disease vulnerability. I will also (Aim2) analyze the transcriptional changes of differentially vulnerable aMN classes upon retrograde labeling and functional denervation by neurotoxin intoxication. This work will return candidate genes directly controlling terminal sprouting and remodeling, critical steps that disease-resistant aMN subtypes normally undertake for neuronal loss compensation upon insult. More broadly, I aim to contribute in filling an important knowledge gap by generating the first transcriptomic roadmap of aMN subtypes, and pinpointing at new candidates for therapy development.

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The information about "MOVEMENT" are provided by the European Opendata Portal: CORDIS opendata.

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