Opendata, web and dolomites

YAP MECHANO SIGNED

Elucidating the mechanism of mechanotransduction through YAP and TAZ

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 YAP MECHANO project word cloud

Explore the words cloud of the YAP MECHANO project. It provides you a very rough idea of what is the project "YAP MECHANO" about.

pioneered    driving    rapid    biochemical    molecular    regulation    spectrometry    mechanosensing    proliferation    mass    crucially    despite    nuclear    instructing    mechanotransduction    tumour    piccolo    forces    therapy    uncovering    network    coactivators    gap    taz    function    act    cell    shuttling    cellular    transcriptional    tension    death    experiencing    progression    genetic    environment    mechanical    subjected    mechanics    regulate    systematically    generality    activation    validation    imaging    effectors    close    plan    implementing    homeostasis    cancer    remodeling    gain    actin    events    interaction    newly    mechanistic    activate    notion    optogenetic    delineate    fate    cytoskeletal    stiffening    cytoskeleton    translocation    experiments    elusive    view    players    expression    outer    derive    probe    behavior    laboratory    hippo    cells    cues    sufficient    link    model    aid    dynamics    tissue    functional    components    tools    biology    deeply    strain    gene    remained    yap    influence    inputs    actomyosin    live    independently   

Project "YAP MECHANO" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITA DEGLI STUDI DI PADOVA 

Organization address
address: VIA 8 FEBBRAIO 2
city: PADOVA
postcode: 35122
website: www.unipd.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 168˙277 €
 EC max contribution 168˙277 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2020-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITA DEGLI STUDI DI PADOVA IT (PADOVA) coordinator 168˙277.00

Map

 Project objective

The mechanical properties of the cellular environment deeply influence cell fate and behavior. Cells respond to outer forces not only through the rapid remodeling of their cytoskeleton, but also by implementing gene expression changes. The Piccolo laboratory pioneered the notion that the transcriptional coactivators YAP and TAZ act independently of the Hippo pathway to activate gene expression in response to cytoskeletal tension. Crucially, YAP/TAZ are the main effectors of the cellular response to mechanical cues instructing proliferation, cell death or cell fate choice. Despite the importance of mechanosensing in development, tissue homeostasis and cancer, the mechanistic link between the actin network and YAP/ TAZ regulation has remained elusive. This project aims to close this gap in our knowledge by uncovering the molecular events that lead to the activation and nuclear translocation of YAP/TAZ in cells experiencing mechanical strain. Using live imaging, I plan to derive a model of the nuclear YAP shuttling dynamics. Optogenetic tools and targeted genetic approaches will be used to delineate which components of the actomyosin network are sufficient to regulate YAP/TAZ and to probe a potential link to nuclear mechanics. Mass spectrometry will provide a comprehensive view of YAP/TAZ interaction partners in cells subjected to different mechanical inputs and biochemical validation experiments will systematically delineate the molecular pathway of mechanotransduction from cytoskeletal tension to YAP/TAZ activation. Finally, loss- and gain-of-function experiments in a range of model systems will establish the functional importance and generality of these newly identified mechanotransduction pathway players. Uncovering the mechanotransduction pathway will not only greatly advance our understanding of cell biology, but also aid to identify potential targets for cancer therapy, as indeed the stiffening of the tumour environment is a driving factor in cancer progression.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "YAP MECHANO" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "YAP MECHANO" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

CoCoNat (2019)

Coordination in constrained and natural distributed systems

Read More  

TeamUp (2020)

Understanding and improving team decision making in uncertain environments

Read More  

PaSION (2018)

A longitudinal assessment of treatment experience, symptoms and potential associations with biomarkers in cancer patients undergoing immune checkpoint inhibitor therapy

Read More