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MIBEst SIGNED

Molecular Infection Biology Estonia - Research capacity building

Total Cost €

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EC-Contrib. €

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Partnership

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 MIBEst project word cloud

Explore the words cloud of the MIBEst project. It provides you a very rough idea of what is the project "MIBEst" about.

smaller    chronic    emphasizing    scientists    transitioning    candidates    infections    biozentrum    multidisciplinary    societal    demand    national    strategies    sweden    biology    full    refractory    medically    infectious    capitalize    morbidity    molecular    antiinfective    fails    microbiology    age    screening    latent    anti    internationally    considerable    links    animal    vaccination    death    outcome    convergence    aging    joint    infection    medicine    ume    centuries    university    requiring    agents    tartu    alone    immunology    treatments    feasible    diversity    stand    countries    throughput    economically    combined    antibiotic    decreased    mibest    switzerland    constant    therapeutics    aring    despite    establishment    capacity    compounds    societies    competencies    estonian    strengthen    estonia    basel    diseases    programs    positions    cell    models    excellence    scientific    frequency    of    hygiene    virology    deaths    global    mortality    altogether    basic    nature    centres    lasting   

Project "MIBEst" data sheet

The following table provides information about the project.

Coordinator
TARTU ULIKOOL 

Organization address
address: ULIKOOLI 18
city: TARTU
postcode: 51005
website: www.ut.ee

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Estonia [EE]
 Total cost 796˙550 €
 EC max contribution 796˙550 € (100%)
 Programme 1. H2020-EU.4.b. (Twinning of research institutions)
 Code Call H2020-WIDESPREAD-2018-03
 Funding Scheme CSA
 Starting year 2019
 Duration (year-month-day) from 2019-09-01   to  2022-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TARTU ULIKOOL EE (TARTU) coordinator 360˙625.00
2    UNIVERSITAT BASEL CH (BASEL) participant 256˙250.00
3    UMEA UNIVERSITET SE (UMEA) participant 179˙675.00

Map

 Project objective

Infectious diseases have been the leading cause of death for many centuries. The development of vaccination and antibiotic treatments combined with improved hygiene has decreased the number of deaths, but the mortality and morbidity associated with infections remain considerable, requiring constant societal awareness and scientific research. An increasing concern are the latent and chronic infections that are often refractory to treatments. As the frequency of latent infections increases with age, it is a major concern for aging societies. The great diversity of the infectious agents, and the multidisciplinary nature of the infectious biology research demand a convergence of various competencies: microbiology, cell biology, animal infection models, immunology etc, emphasizing the need for collaboration between research centres. Especially important are joint activities for smaller countries, e.g. Estonia, where establishment of full-scale stand-alone programs is not economically feasible. Despite the strong positions in basic molecular biology, virology and microbiology, Estonia often fails to capitalize on the excellence in basic research by transitioning to the development of therapeutics targeting medically relevant processes. The main objective of the MIBEst project is to strengthen the research capacity on latent and chronic infections of Institute of Technology at University of Tartu by creating long-lasting links with internationally-leading research institutions: Molecular Infection Medicine Sweden at Umeå University, Sweden, and Basel Biozentrum, University of Basel, Switzerland. As an outcome of MIBEst, Estonian scientists will have new knowledge in infection biology with particular focus on advancement in models for latent infections and high throughput screening for promising candidates for antiinfective compounds. Altogether, it enables development of new anti-infection strategies that will have major impact at the national, European and global scale.

 Publications

year authors and title journal last update
List of publications.
2019 Yee-Song Law, Age Utt, Yaw Bia Tan, Jie Zheng, Sainan Wang, Ming Wei Chen, Patrick R. Griffin, Andres Merits, Dahai Luo
Structural insights into RNA recognition by the Chikungunya virus nsP2 helicase
published pages: 201900656, ISSN: 0027-8424, DOI: 10.1073/pnas.1900656116
Proceedings of the National Academy of Sciences 2019-11-08
2018 Valeria Lulla, Liis Karo-Astover, Kai Rausalu, Sirle Saul, Andres Merits, Aleksei Lulla
Timeliness of Proteolytic Events Is Prerequisite for Efficient Functioning of the Alphaviral Replicase
published pages: , ISSN: 0022-538X, DOI: 10.1128/jvi.00151-18
Journal of Virology 92/14 2019-11-07
2019 Toomas Mets, Sergo Kasvandik, Merilin Saarma, Ülo Maiväli, Tanel Tenson, Niilo Kaldalu
Fragmentation of Escherichia coli mRNA by MazF and MqsR
published pages: 79-91, ISSN: 0300-9084, DOI: 10.1016/j.biochi.2018.10.004
Biochimie 156 2019-11-07
2018 Eva Zusinaite, Aleksandr Ianevski, Diana Niukkanen, Minna Poranen, Magnar Bjørås, Jan Afset, Tanel Tenson, Vidya Velagapudi, Andres Merits, Denis Kainov
A Systems Approach to Study Immuno- and Neuro-Modulatory Properties of Antiviral Agents
published pages: 423, ISSN: 1999-4915, DOI: 10.3390/v10080423
Viruses 10/8 2019-11-07
2019 Aleksandr Ianevski, Eva Zusinaite, Nastassia Shtaida, Hannimari Kallio-Kokko, Miia Valkonen, Anu Kantele, Kaidi Telling, Irja Lutsar, Pille Letjuka, Natalja Metelitsa, Valentyn Oksenych, Uga Dumpis, Astra Vitkauskiene, Kestutis Stašaitis, Christina Öhrmalm, Kåre Bondeson, Anders Bergqvist, Rebecca Cox, Tanel Tenson, Andres Merits, Denis Kainov
Low Temperature and Low UV Indexes Correlated with Peaks of Influenza Virus Activity in Northern Europe during 2010–2018
published pages: 207, ISSN: 1999-4915, DOI: 10.3390/v11030207
Viruses 11/3 2019-11-07
2019 Yi‐Hao Chan, Teck‐Hui Teo, Age Utt, Jeslin JL Tan, Siti Naqiah Amrun, Farhana Abu Bakar, Wearn‐Xin Yee, Etienne Becht, Cheryl Yi‐Pin Lee, Bernett Lee, Ravisankar Rajarethinam, Evan Newell, Andres Merits, Guillaume Carissimo, Fok‐Moon Lum, Lisa FP Ng
Mutating chikungunya virus non‐structural protein produces potent live‐attenuated vaccine candidate
published pages: e10092, ISSN: 1757-4676, DOI: 10.15252/emmm.201810092
EMBO Molecular Medicine 11/6 2019-11-07
2017 Liis Preem, Mohammad Mahmoudzadeh, Marta Putrinš, Andres Meos, Ivo Laidmäe, Tavo Romann, Jaan Aruväli, Riinu Härmas, Artturi Koivuniemi, Alex Bunker, Tanel Tenson, Karin Kogermann
Interactions between Chloramphenicol, Carrier Polymers, and Bacteria–Implications for Designing Electrospun Drug Delivery Systems Countering Wound Infection
published pages: 4417-4430, ISSN: 1543-8384, DOI: 10.1021/acs.molpharmaceut.7b00524
Molecular Pharmaceutics 14/12 2019-11-07
2019 Preem, Bock, Hinnu, Putrinš, Sagor, Tenson, Meos, Østergaard, Kogermann
Monitoring of Antimicrobial Drug Chloramphenicol Release from Electrospun Nano- and Microfiber Mats using UV Imaging and Bacterial Bioreporters
published pages: 487, ISSN: 1999-4923, DOI: 10.3390/pharmaceutics11090487
Pharmaceutics 11/9 2019-11-07
2018 Kaidi Telling, Mailis Laht, Age Brauer, Maido Remm, Veljo Kisand, Matti Maimets, Tanel Tenson, Irja Lutsar
Multidrug resistant Pseudomonas aeruginosa in Estonian hospitals
published pages: , ISSN: 1471-2334, DOI: 10.1186/s12879-018-3421-1
BMC Infectious Diseases 18/1 2019-11-07
2017 Adam Taylor, Xiang Liu, Ali Zaid, Lucas Y. H. Goh, Jody Hobson-Peters, Roy A. Hall, Andres Merits, Suresh Mahalingam
Mutation of the N-Terminal Region of Chikungunya Virus Capsid Protein: Implications for Vaccine Design
published pages: , ISSN: 2150-7511, DOI: 10.1128/mbio.01970-16
mBio 8/1 2019-11-07
2016 Ülar Allas, Lauri Toom, Anastasia Selyutina, Uno Mäeorg, Ricardo Medina, Andres Merits, Ago Rinken, Vasili Hauryliuk, Niilo Kaldalu, Tanel Tenson
Antibacterial activity of the nitrovinylfuran G1 (Furvina) and its conversion products
published pages: , ISSN: 2045-2322, DOI: 10.1038/srep36844
Scientific Reports 6/1 2019-11-07
2018 Melek Cemre Manav, Jelena Beljantseva, Martin S. Bojer, Tanel Tenson, Hanne Ingmer, Vasili Hauryliuk, Ditlev E. Brodersen
Structural basis for (p)ppGpp synthesis by the Staphylococcus aureus small alarmone synthetase RelP
published pages: 3254-3264, ISSN: 0021-9258, DOI: 10.1074/jbc.ra117.001374
Journal of Biological Chemistry 293/9 2019-11-07
2018 Erki Aun, Age Brauer, Veljo Kisand, Tanel Tenson, Maido Remm
A k-mer-based method for the identification of phenotype-associated genomic biomarkers and predicting phenotypes of sequenced bacteria
published pages: e1006434, ISSN: 1553-7358, DOI: 10.1371/journal.pcbi.1006434
PLOS Computational Biology 14/10 2019-11-07
2016 Age Brauer, Kaidi Telling, Mailis Laht, Piret Kalmus, Irja Lutsar, Maido Remm, Veljo Kisand, Tanel Tenson
Plasmid with Colistin Resistance Gene mcr-1 in Extended-Spectrum-β-Lactamase-Producing Escherichia coli Strains Isolated from Pig Slurry in Estonia
published pages: 6933-6936, ISSN: 0066-4804, DOI: 10.1128/aac.00443-16
Antimicrobial Agents and Chemotherapy 60/11 2019-11-07
2017 Pavel Kudrin, Vallo Varik, Sofia Raquel Alves Oliveira, Jelena Beljantseva, Teresa Del Peso Santos, Ievgen Dzhygyr, Dominik Rejman, Felipe Cava, Tanel Tenson, Vasili Hauryliuk
Subinhibitory Concentrations of Bacteriostatic Antibiotics Induce relA -Dependent and relA -Independent Tolerance to β-Lactams
published pages: , ISSN: 0066-4804, DOI: 10.1128/aac.02173-16
Antimicrobial Agents and Chemotherapy 61/4 2019-11-07
2018 Koen Bartholomeeusen, Age Utt, Sandra Coppens, Kai Rausalu, Katleen Vereecken, Kevin K. Ariën, Andres Merits
A Chikungunya Virus trans -Replicase System Reveals the Importance of Delayed Nonstructural Polyprotein Processing for Efficient Replication Complex Formation in Mosquito Cells
published pages: , ISSN: 0022-538X, DOI: 10.1128/jvi.00152-18
Journal of Virology 92/14 2019-11-07
2017 Kirsi Hellström, Katri Kallio, Age Utt, Tania Quirin, Eija Jokitalo, Andres Merits, Tero Ahola
Partially Uncleaved Alphavirus Replicase Forms Spherule Structures in the Presence and Absence of RNA Template
published pages: , ISSN: 0022-538X, DOI: 10.1128/jvi.00787-17
Journal of Virology 91/18 2019-11-07
2016 Kai Rausalu, Age Utt, Tania Quirin, Finny S. Varghese, Eva Žusinaite, Pratyush Kumar Das, Tero Ahola, Andres Merits
Chikungunya virus infectivity, RNA replication and non-structural polyprotein processing depend on the nsP2 protease’s active site cysteine residue
published pages: , ISSN: 2045-2322, DOI: 10.1038/srep37124
Scientific Reports 6/1 2019-11-07
2019 Age Utt, Kai Rausalu, Madis Jakobson, Andres Männik, Luke Alphey, Rennos Fragkoudis, Andres Merits
Design and Use of Chikungunya Virus Replication Templates Utilizing Mammalian and Mosquito RNA Polymerase I-Mediated Transcription
published pages: , ISSN: 0022-538X, DOI: 10.1128/jvi.00794-19
Journal of Virology 93/18 2019-11-07
2016 Pierre V Maillard, Annemarthe G Van der Veen, Safia Deddouche‐Grass, Neil C Rogers, Andres Merits, Caetano Reis e Sousa
Inactivation of the type I interferon pathway reveals long double‐stranded RNA ‐mediated RNA interference in mammalian cells
published pages: 2505-2518, ISSN: 0261-4189, DOI: 10.15252/embj.201695086
The EMBO Journal 35/23 2019-11-07
2016 Liis Andresen, Tanel Tenson, Vasili Hauryliuk
Cationic bactericidal peptide 1018 does not specifically target the stringent response alarmone (p)ppGpp
published pages: , ISSN: 2045-2322, DOI: 10.1038/srep36549
Scientific Reports 6/1 2019-11-07
2019 Victoriia Murina, Marje Kasari, Hiraku Takada, Mariliis Hinnu, Chayan Kumar Saha, James W. Grimshaw, Takahiro Seki, Michael Reith, Marta Putrinš, Tanel Tenson, Henrik Strahl, Vasili Hauryliuk, Gemma Catherine Atkinson
ABCF ATPases Involved in Protein Synthesis, Ribosome Assembly and Antibiotic Resistance: Structural and Functional Diversification across the Tree of Life
published pages: 3568-3590, ISSN: 0022-2836, DOI: 10.1016/j.jmb.2018.12.013
Journal of Molecular Biology 431/18 2019-11-07
2018 Pavel Kudrin, Ievgen Dzhygyr, Kensuke Ishiguro, Jelena Beljantseva, Elena Maksimova, Sofia Raquel Alves Oliveira, Vallo Varik, Roshani Payoe, Andrey L Konevega, Tanel Tenson, Tsutomu Suzuki, Vasili Hauryliuk
The ribosomal A-site finger is crucial for binding and activation of the stringent factor RelA
published pages: 1973-1983, ISSN: 0305-1048, DOI: 10.1093/nar/gky023
Nucleic Acids Research 46/4 2019-11-07
2019 Alla Piirsoo, Marko Piirsoo, Martin Kala, Eve Sankovski, Elina Lototskaja, Viktor Levin, Mauro Salvi, Mart Ustav
Activity of CK2α protein kinase is required for efficient replication of some HPV types
published pages: e1007788, ISSN: 1553-7374, DOI: 10.1371/journal.ppat.1007788
PLOS Pathogens 15/5 2019-11-07
2018 Rachy Abraham, Debra Hauer, Robert Lyle McPherson, Age Utt, Ilsa T. Kirby, Michael S. Cohen, Andres Merits, Anthony K. L. Leung, Diane E. Griffin
ADP-ribosyl–binding and hydrolase activities of the alphavirus nsP3 macrodomain are critical for initiation of virus replication
published pages: E10457-E10466, ISSN: 0027-8424, DOI: 10.1073/pnas.1812130115
Proceedings of the National Academy of Sciences 115/44 2019-11-07
2016 Pratyush Kumar Das, Laura Puusepp, Finny S. Varghese, Age Utt, Tero Ahola, Dzmitry G. Kananovich, Margus Lopp, Andres Merits, Mati Karelson
Design and validation of novel chikungunya virus protease inhibitors
published pages: AAC.01421-16, ISSN: 0066-4804, DOI: 10.1128/aac.01421-16
Antimicrobial Agents and Chemotherapy 2019-11-07
2018 Frédéric Goormaghtigh, Nathan Fraikin, Marta Putrinš, Thibaut Hallaert, Vasili Hauryliuk, Abel Garcia-Pino, Andreas Sjödin, Sergo Kasvandik, Klas Udekwu, Tanel Tenson, Niilo Kaldalu, Laurence Van Melderen
Reassessing the Role of Type II Toxin-Antitoxin Systems in Formation of Escherichia coli Type II Persister Cells
published pages: , ISSN: 2150-7511, DOI: 10.1128/mbio.00640-18
mBio 9/3 2019-11-07
2017 Jelena Beljantseva, Pavel Kudrin, Steffi Jimmy, Marcel Ehn, Radek Pohl, Vallo Varik, Yuzuru Tozawa, Victoria Shingler, Tanel Tenson, Dominik Rejman, Vasili Hauryliuk
Molecular mutagenesis of ppGpp: turning a RelA activator into an inhibitor
published pages: , ISSN: 2045-2322, DOI: 10.1038/srep41839
Scientific Reports 7/1 2019-11-07
2019 Nathalie Q. Balaban, Sophie Helaine, Kim Lewis, Martin Ackermann, Bree Aldridge, Dan I. Andersson, Mark P. Brynildsen, Dirk Bumann, Andrew Camilli, James J. Collins, Christoph Dehio, Sarah Fortune, Jean-Marc Ghigo, Wolf-Dietrich Hardt, Alexander Harms, Matthias Heinemann, Deborah T. Hung, Urs Jenal, Bruce R. Levin, Jan Michiels, Gisela Storz, Man-Wah Tan, Tanel Tenson, Laurence Van Melderen, Annel
Definitions and guidelines for research on antibiotic persistence
published pages: 441-448, ISSN: 1740-1526, DOI: 10.1038/s41579-019-0196-3
Nature Reviews Microbiology 17/7 2019-11-07
2018 Aleksandr Ianevski, Eva Zusinaite, Suvi Kuivanen, Mårten Strand, Hilde Lysvand, Mona Teppor, Laura Kakkola, Henrik Paavilainen, Mira Laajala, Hannimari Kallio-Kokko, Miia Valkonen, Anu Kantele, Kaidi Telling, Irja Lutsar, Pille Letjuka, Natalja Metelitsa, Valentyn Oksenych, Magnar Bjørås, Svein Arne Nordbø, Uga Dumpis, Astra Vitkauskiene, Christina Öhrmalm, Kåre Bondeson, Anders Bergqvist, T
Novel activities of safe-in-human broad-spectrum antiviral agents
published pages: 174-182, ISSN: 0166-3542, DOI: 10.1016/j.antiviral.2018.04.016
Antiviral Research 154 2019-11-07
2019 Niilo Kaldalu, Tanel Tenson
Slow growth causes bacterial persistence
published pages: eaay1167, ISSN: 1937-9145, DOI: 10.1126/scisignal.aay1167
Science Signaling 12/592 2019-11-07
2017 Jung Shim, Jinhee Kim, Tanel Tenson, Ji-Young Min, Denis Kainov
Influenza Virus Infection, Interferon Response, Viral Counter-Response, and Apoptosis
published pages: 223, ISSN: 1999-4915, DOI: 10.3390/v9080223
Viruses 9/8 2019-11-07
2018 Xiang Liu, Margit Mutso, Age Utt, Anni Lepland, Lara J. Herrero, Adam Taylor, Jayaram Bettadapura, Penny A. Rudd, Andres Merits, Suresh Mahalingam
Decreased Virulence of Ross River Virus Harboring a Mutation in the First Cleavage Site of Nonstructural Polyprotein Is Caused by a Novel Mechanism Leading to Increased Production of Interferon-Inducing RNAs
published pages: , ISSN: 2150-7511, DOI: 10.1128/mbio.00044-18
mBio 9/4 2019-11-07
2016 Karin Kogermann, Marta Putrinš, Tanel Tenson
Single-cell level methods for studying the effect of antibiotics on bacteria during infection
published pages: 2-16, ISSN: 0928-0987, DOI: 10.1016/j.ejps.2016.08.042
European Journal of Pharmaceutical Sciences 95 2019-11-07
2017 Teck-Hui Teo, Yi-Hao Chan, Wendy W. L. Lee, Fok-Moon Lum, Siti Naqiah Amrun, Zhisheng Her, Ravisankar Rajarethinam, Andres Merits, Olaf Rötzschke, Laurent Rénia, Lisa F. P. Ng
Fingolimod treatment abrogates chikungunya virus–induced arthralgia
published pages: eaal1333, ISSN: 1946-6234, DOI: 10.1126/scitranslmed.aal1333
Science Translational Medicine 9/375 2019-11-07
2017 Vallo Varik, Sofia Raquel Alves Oliveira, Vasili Hauryliuk, Tanel Tenson
HPLC-based quantification of bacterial housekeeping nucleotides and alarmone messengers ppGpp and pppGpp
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-10988-6
Scientific Reports 7/1 2019-11-07
2018 Špela Zupančič, Liis Preem, Julijana Kristl, Marta Putrinš, Tanel Tenson, Petra Kocbek, Karin Kogermann
Impact of PCL nanofiber mat structural properties on hydrophilic drug release and antibacterial activity on periodontal pathogens
published pages: 347-358, ISSN: 0928-0987, DOI: 10.1016/j.ejps.2018.07.024
European Journal of Pharmaceutical Sciences 122 2019-11-07
2019 Niilo Kaldalu, Ülo Maiväli, Vasili Hauryliuk, Tanel Tenson
Reanalysis of Proteomics Results Fails To Detect MazF-Mediated Stress Proteins
published pages: , ISSN: 2150-7511, DOI: 10.1128/mbio.00949-19
mBio 10/3 2019-11-07
2017 Jelena Beljantseva, Pavel Kudrin, Liis Andresen, Victoria Shingler, Gemma C. Atkinson, Tanel Tenson, Vasili Hauryliuk
Negative allosteric regulation of Enterococcus faecalis small alarmone synthetase RelQ by single-stranded RNA
published pages: 3726-3731, ISSN: 0027-8424, DOI: 10.1073/pnas.1617868114
Proceedings of the National Academy of Sciences 114/14 2019-11-07

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