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DynAMic SIGNED

Dynamic adaptive microscopy for label-free multi-parametric imaging in biology and medicine

Total Cost €

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EC-Contrib. €

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Partnership

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 DynAMic project word cloud

Explore the words cloud of the DynAMic project. It provides you a very rough idea of what is the project "DynAMic" about.

fundamental    light    vivo    variations    regard    agendi    first    expands    nature    lt    raman    label    compensating    fluorescent    sensing    probes    performance    tenfold    random    concurrently    proteins    retinal    optics    refractive    limitations    visualization    imaging    constitutes    microscopy    polarization    few    radically    proposes    events    multiplexing    deeper    delivered    adaptive    disrupting    linking    mean    shaping    biological    brain    proteomics    index    image    dynamic    living    retrieved    observation    ophthalmology    generation    modus    depths    diffusion    inversing    time    disease    conventional    limits    1mm    invasive    wavefront    paths    operandi    propagation    monitoring    tissue    least    proteomic    disturbing    scattering    fluorochromes    interrogations    ophthalmic    free    stimulated    devastating    window    optical    genomics    nervous    paradigms    labels    incompatible    utilize    sensitivity    reaching    diffusing    contrast    retrieval    detection    functional    medical    parametric    ideal    superficial    neurology    spectrally   

Project "DynAMic" data sheet

The following table provides information about the project.

Coordinator
IDRYMA TECHNOLOGIAS KAI EREVNAS 

Organization address
address: N PLASTIRA STR 100
city: IRAKLEIO
postcode: 70013
website: www.forth.gr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Greece [EL]
 Total cost 3˙957˙137 €
 EC max contribution 3˙957˙137 € (100%)
 Programme 1. H2020-EU.1.2.1. (FET Open)
 Code Call H2020-FETOPEN-2018-2019-2020-01
 Funding Scheme RIA
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    IDRYMA TECHNOLOGIAS KAI EREVNAS EL (IRAKLEIO) coordinator 605˙000.00
2    TECHNISCHE UNIVERSITAET MUENCHEN DE (MUENCHEN) participant 697˙092.00
3    THE UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS UK (ST ANDREWS) participant 649˙316.00
4    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) participant 597˙296.00
5    IMAGINE OPTIC FR (ORSAY) participant 498˙900.00
6    RAYFOS LTD UK (BASINGSTOKE) participant 493˙657.00
7    EBERHARD KARLS UNIVERSITAET TUEBINGEN DE (TUEBINGEN) participant 415˙875.00

Map

 Project objective

Optical microscopy constitutes one of the most fundamental paradigms in biological and medical imaging. However, significant challenges remain in regard to the application of optical microscopy to in vivo interrogations. First, the diffusing nature of light propagation in tissue due to random variations of the refractive index, limits in vivo microscopy to superficial depths; within only a few mean free paths (<1mm). Second the invasive nature of fluorescent proteins and probes, allows monitoring of only 1-5 events by spectrally multiplexing different fluorochromes; i.e. performance that is highly incompatible with the targets of functional genomics and proteomics. This proposal aims to develop the next step in optical visualization by addressing these two fundamental limitations of optical imaging, i.e. Depth and Contrast. To achieve this, DynAMic proposes a radically new concept for optical imaging of tissue based on ❶ developing real-time wavefront-shaping adaptive optics for making the performance of any optical system ideal and for the first time in Raman microscopy ❷ reaching tenfold deeper in tissue than conventional optical microscopy by compensating for the refractive index variations using phase and polarization retrieval for inversing light diffusion and ❸ utilize advance image formation to improve the sensitivity and utilization of stimulated Raman scattering for multi-parametric label-free contrast that radically expands at least tenfold the number of labels concurrently retrieved from living systems, linking optical observation to functional proteomic requirements. The new optical imaging ability delivered in DynAMic will be applied to a first target application of ophthalmic imaging, also used as a window to the brain and devastating nervous disease detection, defining the next generation ophthalmology and neurology sensing, disrupting the modus operandi of retinal imaging without disturbing the modus agendi of the end users.

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The information about "DYNAMIC" are provided by the European Opendata Portal: CORDIS opendata.

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