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DynAMic SIGNED

Dynamic adaptive microscopy for label-free multi-parametric imaging in biology and medicine

Total Cost €

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EC-Contrib. €

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Partnership

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 DynAMic project word cloud

Explore the words cloud of the DynAMic project. It provides you a very rough idea of what is the project "DynAMic" about.

mean    lt    linking    raman    labels    scattering    propagation    random    retrieved    paths    living    refractive    fluorochromes    neurology    medical    sensing    performance    limitations    multiplexing    deeper    adaptive    tissue    retrieval    inversing    1mm    variations    label    wavefront    ideal    proteins    optics    few    incompatible    contrast    events    tenfold    constitutes    limits    conventional    image    window    optical    interrogations    polarization    stimulated    detection    monitoring    agendi    modus    retinal    disturbing    observation    microscopy    proteomics    invasive    generation    shaping    proposes    diffusing    depths    least    proteomic    index    biological    ophthalmology    genomics    imaging    ophthalmic    compensating    concurrently    expands    delivered    visualization    regard    superficial    radically    disrupting    fundamental    sensitivity    utilize    light    dynamic    free    brain    first    probes    operandi    functional    time    reaching    nature    disease    nervous    diffusion    vivo    fluorescent    spectrally    paradigms    devastating    parametric   

Project "DynAMic" data sheet

The following table provides information about the project.

Coordinator
IDRYMA TECHNOLOGIAS KAI EREVNAS 

Organization address
address: N PLASTIRA STR 100
city: IRAKLEIO
postcode: 70013
website: www.forth.gr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Greece [EL]
 Total cost 3˙957˙137 €
 EC max contribution 3˙957˙137 € (100%)
 Programme 1. H2020-EU.1.2.1. (FET Open)
 Code Call H2020-FETOPEN-2018-2019-2020-01
 Funding Scheme RIA
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    IDRYMA TECHNOLOGIAS KAI EREVNAS EL (IRAKLEIO) coordinator 605˙000.00
2    TECHNISCHE UNIVERSITAET MUENCHEN DE (MUENCHEN) participant 697˙092.00
3    THE UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS UK (ST ANDREWS) participant 649˙316.00
4    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) participant 597˙296.00
5    IMAGINE OPTIC FR (ORSAY) participant 498˙900.00
6    RAYFOS LTD UK (BASINGSTOKE) participant 493˙657.00
7    EBERHARD KARLS UNIVERSITAET TUEBINGEN DE (TUEBINGEN) participant 415˙875.00

Map

 Project objective

Optical microscopy constitutes one of the most fundamental paradigms in biological and medical imaging. However, significant challenges remain in regard to the application of optical microscopy to in vivo interrogations. First, the diffusing nature of light propagation in tissue due to random variations of the refractive index, limits in vivo microscopy to superficial depths; within only a few mean free paths (<1mm). Second the invasive nature of fluorescent proteins and probes, allows monitoring of only 1-5 events by spectrally multiplexing different fluorochromes; i.e. performance that is highly incompatible with the targets of functional genomics and proteomics. This proposal aims to develop the next step in optical visualization by addressing these two fundamental limitations of optical imaging, i.e. Depth and Contrast. To achieve this, DynAMic proposes a radically new concept for optical imaging of tissue based on ❶ developing real-time wavefront-shaping adaptive optics for making the performance of any optical system ideal and for the first time in Raman microscopy ❷ reaching tenfold deeper in tissue than conventional optical microscopy by compensating for the refractive index variations using phase and polarization retrieval for inversing light diffusion and ❸ utilize advance image formation to improve the sensitivity and utilization of stimulated Raman scattering for multi-parametric label-free contrast that radically expands at least tenfold the number of labels concurrently retrieved from living systems, linking optical observation to functional proteomic requirements. The new optical imaging ability delivered in DynAMic will be applied to a first target application of ophthalmic imaging, also used as a window to the brain and devastating nervous disease detection, defining the next generation ophthalmology and neurology sensing, disrupting the modus operandi of retinal imaging without disturbing the modus agendi of the end users.

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The information about "DYNAMIC" are provided by the European Opendata Portal: CORDIS opendata.

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