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Perinatal Life Support System: Integration of Enabling Technologies for Clinical Translation

Total Cost €


EC-Contrib. €






 PLS project word cloud

Explore the words cloud of the PLS project. It provides you a very rough idea of what is the project "PLS" about.

inadequate    disabilities    data    prepared    preserving    vivo    necrotizing    proportion    solutions    every    obstetrics    bleeding    pls    oxygenation    gut    causes    regeneration    feasible    organ    demonstration    decision    safe    industry    input    nutrient    gas    germinal    artificial    device    organs    urgent    neurological    academia    fast    smallest    care    cardiorespiratory    ep    28    age    preclinical    infants    engineering    morbidity    lifelong    underlying    accurately    nutrition    cardiac    clinical    exchange    validation    ventilation    liquid    proof    innate    transplantation    simulate    oxygen    outside    environment    air    primarily    lt    progress    lacking    initiation    physiology    neonatology    born    computational    medical    models    perfusion    worldwide    monitoring    life    group    respective    intensive    setting    applicable    manikin    envisions    perinatal    dysplasia    continuous    interdisciplinary    ex    preterm    acute    matrix    final    invasive    survivors    babies    bronchopulmonary    simulation    fetal    physiological    heart    translation    placenta    weeks    breathing    extremely    lungs    metabolic    therapy    womb    body    mechanical    enterocolitis    trials    800    rate    treatment    technologies    energy    innovative    functions   

Project "PLS" data sheet

The following table provides information about the project.


Organization address
address: GROENE LOPER 3
postcode: 5612 AE

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 2˙876˙131 €
 EC max contribution 2˙876˙131 € (100%)
 Programme 1. H2020-EU.1.2.1. (FET Open)
 Code Call H2020-FETOPEN-2018-2019-2020-01
 Funding Scheme RIA
 Starting year 2019
 Duration (year-month-day) from 2019-10-01   to  2024-09-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
3    LIFETEC GROUP BV NL (EINDHOVEN) participant 451˙875.00
4    POLITECNICO DI MILANO IT (MILANO) participant 400˙000.00
5    NEMO HEALTHCARE BV NL (VELDHOVEN) participant 399˙812.00


 Project objective

Every year, 800.000 babies are born extremely preterm (EP; <28 weeks of age) worldwide. A large proportion of survivors from this group of smallest infants face lifelong disabilities, including breathing, cardiac, neurological and metabolic problems. Current treatment requires the preterm initiation of body functions for which the respective organs are not prepared. This affects primarily the lungs which need to provide gas-exchange under air (i.e. oxygen-based mechanical ventilation), and the gut, which is needed for energy and nutrition. This approach causes major therapy-related morbidity such as bronchopulmonary dysplasia, necrotizing enterocolitis and germinal matrix bleeding. The Perinatal Life Support (PLS) consortium envisions a medical device that can support the safe development of EP infants outside the womb by preserving the innate fetal cardiorespiratory physiology ex vivo, with the following enabling technologies: 1. A liquid-based environment with oxygen and nutrient exchange using an ´artificial placenta´; 2. Continuous and non-invasive monitoring of fetal parameters such as heart rate and oxygenation; 3. Computational models for fast and objective clinical decision support based on physiological data input; 4. A fetal manikin that can accurately simulate EP infants in an intensive care setting. The PLS project will be carried out by an interdisciplinary group of academia and industry with experience in modelling, monitoring, engineering, obstetrics and neonatology. The technology underlying PLS is applicable to conditions where ex vivo life support is required e.g. organ perfusion, regeneration and transplantation. The integrated system will allow major progress towards translation for an urgent medical need, where new solutions are lacking as preclinical models are inadequate and clinical trials not feasible. Innovative simulation technology will enable technical validation of PLS, with demonstration of functionality in a final Proof-of-Principle.

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The information about "PLS" are provided by the European Opendata Portal: CORDIS opendata.

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