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PLS SIGNED

Perinatal Life Support System: Integration of Enabling Technologies for Clinical Translation

Total Cost €

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EC-Contrib. €

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Partnership

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 PLS project word cloud

Explore the words cloud of the PLS project. It provides you a very rough idea of what is the project "PLS" about.

functions    perinatal    feasible    care    perfusion    clinical    mechanical    prepared    lungs    therapy    air    device    accurately    born    proportion    matrix    preserving    proof    computational    extremely    applicable    age    bronchopulmonary    vivo    continuous    gas    outside    organ    gut    disabilities    input    placenta    simulation    transplantation    environment    obstetrics    causes    lacking    neonatology    primarily    innovative    babies    intensive    regeneration    ep    smallest    fast    invasive    validation    survivors    nutrient    physiological    data    demonstration    safe    academia    industry    acute    decision    inadequate    engineering    body    interdisciplinary    28    morbidity    organs    weeks    technologies    every    heart    translation    breathing    enterocolitis    neurological    underlying    ventilation    preterm    progress    preclinical    energy    trials    final    respective    initiation    treatment    germinal    bleeding    manikin    rate    pls    medical    oxygenation    liquid    cardiorespiratory    metabolic    solutions    simulate    innate    models    lifelong    urgent    setting    infants    fetal    group    dysplasia    life    envisions    worldwide    oxygen    artificial    nutrition    womb    monitoring    necrotizing    cardiac    exchange    physiology    lt    ex    800   

Project "PLS" data sheet

The following table provides information about the project.

Coordinator
TECHNISCHE UNIVERSITEIT EINDHOVEN 

Organization address
address: GROENE LOPER 3
city: EINDHOVEN
postcode: 5612 AE
website: www.tue.nl/en

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 2˙876˙131 €
 EC max contribution 2˙876˙131 € (100%)
 Programme 1. H2020-EU.1.2.1. (FET Open)
 Code Call H2020-FETOPEN-2018-2019-2020-01
 Funding Scheme RIA
 Starting year 2019
 Duration (year-month-day) from 2019-10-01   to  2024-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TECHNISCHE UNIVERSITEIT EINDHOVEN NL (EINDHOVEN) coordinator 792˙500.00
2    UNIVERSITAETSKLINIKUM AACHEN DE (AACHEN) participant 831˙943.00
3    LIFETEC GROUP BV NL (EINDHOVEN) participant 451˙875.00
4    POLITECNICO DI MILANO IT (MILANO) participant 400˙000.00
5    NEMO HEALTHCARE BV NL (VELDHOVEN) participant 399˙812.00

Map

 Project objective

Every year, 800.000 babies are born extremely preterm (EP; <28 weeks of age) worldwide. A large proportion of survivors from this group of smallest infants face lifelong disabilities, including breathing, cardiac, neurological and metabolic problems. Current treatment requires the preterm initiation of body functions for which the respective organs are not prepared. This affects primarily the lungs which need to provide gas-exchange under air (i.e. oxygen-based mechanical ventilation), and the gut, which is needed for energy and nutrition. This approach causes major therapy-related morbidity such as bronchopulmonary dysplasia, necrotizing enterocolitis and germinal matrix bleeding. The Perinatal Life Support (PLS) consortium envisions a medical device that can support the safe development of EP infants outside the womb by preserving the innate fetal cardiorespiratory physiology ex vivo, with the following enabling technologies: 1. A liquid-based environment with oxygen and nutrient exchange using an ´artificial placenta´; 2. Continuous and non-invasive monitoring of fetal parameters such as heart rate and oxygenation; 3. Computational models for fast and objective clinical decision support based on physiological data input; 4. A fetal manikin that can accurately simulate EP infants in an intensive care setting. The PLS project will be carried out by an interdisciplinary group of academia and industry with experience in modelling, monitoring, engineering, obstetrics and neonatology. The technology underlying PLS is applicable to conditions where ex vivo life support is required e.g. organ perfusion, regeneration and transplantation. The integrated system will allow major progress towards translation for an urgent medical need, where new solutions are lacking as preclinical models are inadequate and clinical trials not feasible. Innovative simulation technology will enable technical validation of PLS, with demonstration of functionality in a final Proof-of-Principle.

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The information about "PLS" are provided by the European Opendata Portal: CORDIS opendata.

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