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Perinatal Life Support System: Integration of Enabling Technologies for Clinical Translation

Total Cost €


EC-Contrib. €






 PLS project word cloud

Explore the words cloud of the PLS project. It provides you a very rough idea of what is the project "PLS" about.

preserving    life    respective    survivors    air    academia    urgent    feasible    organ    heart    care    inadequate    fetal    vivo    cardiac    physiology    simulation    models    applicable    dysplasia    accurately    intensive    perfusion    gut    born    prepared    computational    decision    final    pls    clinical    monitoring    primarily    functions    group    breathing    acute    lungs    industry    continuous    smallest    enterocolitis    simulate    proportion    germinal    validation    liquid    matrix    mechanical    treatment    lifelong    neurological    body    cardiorespiratory    progress    setting    invasive    every    bronchopulmonary    outside    obstetrics    placenta    innate    medical    underlying    neonatology    physiological    gas    nutrition    infants    fast    environment    therapy    metabolic    oxygen    ex    interdisciplinary    lacking    exchange    disabilities    rate    energy    worldwide    organs    causes    necrotizing    ventilation    artificial    preclinical    preterm    regeneration    initiation    age    trials    morbidity    nutrient    safe    28    innovative    800    input    proof    weeks    transplantation    envisions    engineering    oxygenation    data    ep    translation    device    womb    solutions    lt    babies    demonstration    technologies    manikin    extremely    perinatal    bleeding   

Project "PLS" data sheet

The following table provides information about the project.


Organization address
address: GROENE LOPER 3
postcode: 5612 AE

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 2˙876˙131 €
 EC max contribution 2˙876˙131 € (100%)
 Programme 1. H2020-EU.1.2.1. (FET Open)
 Code Call H2020-FETOPEN-2018-2019-2020-01
 Funding Scheme RIA
 Starting year 2019
 Duration (year-month-day) from 2019-10-01   to  2024-09-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
3    LIFETEC GROUP BV NL (EINDHOVEN) participant 451˙875.00
4    POLITECNICO DI MILANO IT (MILANO) participant 400˙000.00
5    NEMO HEALTHCARE BV NL (VELDHOVEN) participant 399˙812.00


 Project objective

Every year, 800.000 babies are born extremely preterm (EP; <28 weeks of age) worldwide. A large proportion of survivors from this group of smallest infants face lifelong disabilities, including breathing, cardiac, neurological and metabolic problems. Current treatment requires the preterm initiation of body functions for which the respective organs are not prepared. This affects primarily the lungs which need to provide gas-exchange under air (i.e. oxygen-based mechanical ventilation), and the gut, which is needed for energy and nutrition. This approach causes major therapy-related morbidity such as bronchopulmonary dysplasia, necrotizing enterocolitis and germinal matrix bleeding. The Perinatal Life Support (PLS) consortium envisions a medical device that can support the safe development of EP infants outside the womb by preserving the innate fetal cardiorespiratory physiology ex vivo, with the following enabling technologies: 1. A liquid-based environment with oxygen and nutrient exchange using an ´artificial placenta´; 2. Continuous and non-invasive monitoring of fetal parameters such as heart rate and oxygenation; 3. Computational models for fast and objective clinical decision support based on physiological data input; 4. A fetal manikin that can accurately simulate EP infants in an intensive care setting. The PLS project will be carried out by an interdisciplinary group of academia and industry with experience in modelling, monitoring, engineering, obstetrics and neonatology. The technology underlying PLS is applicable to conditions where ex vivo life support is required e.g. organ perfusion, regeneration and transplantation. The integrated system will allow major progress towards translation for an urgent medical need, where new solutions are lacking as preclinical models are inadequate and clinical trials not feasible. Innovative simulation technology will enable technical validation of PLS, with demonstration of functionality in a final Proof-of-Principle.

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The information about "PLS" are provided by the European Opendata Portal: CORDIS opendata.

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