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PLS SIGNED

Perinatal Life Support System: Integration of Enabling Technologies for Clinical Translation

Total Cost €

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EC-Contrib. €

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Partnership

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 PLS project word cloud

Explore the words cloud of the PLS project. It provides you a very rough idea of what is the project "PLS" about.

care    input    engineering    nutrition    preterm    manikin    interdisciplinary    models    pls    technologies    oxygen    preserving    intensive    transplantation    environment    placenta    academia    800    underlying    safe    neurological    setting    disabilities    trials    cardiorespiratory    worldwide    group    morbidity    smallest    bronchopulmonary    28    matrix    bleeding    applicable    extremely    lt    computational    rate    simulation    preclinical    validation    organ    born    perfusion    innate    survivors    lungs    innovative    therapy    heart    medical    life    regeneration    continuous    breathing    body    initiation    feasible    weeks    infants    enterocolitis    demonstration    primarily    translation    inadequate    accurately    envisions    ex    mechanical    gas    functions    prepared    proportion    data    physiology    clinical    cardiac    ep    nutrient    artificial    vivo    causes    invasive    fetal    treatment    organs    decision    obstetrics    liquid    final    metabolic    germinal    babies    industry    monitoring    perinatal    every    simulate    outside    device    ventilation    energy    womb    exchange    lacking    urgent    lifelong    neonatology    physiological    oxygenation    progress    air    acute    necrotizing    solutions    respective    fast    dysplasia    gut    age    proof   

Project "PLS" data sheet

The following table provides information about the project.

Coordinator
TECHNISCHE UNIVERSITEIT EINDHOVEN 

Organization address
address: GROENE LOPER 3
city: EINDHOVEN
postcode: 5612 AE
website: www.tue.nl/en

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 2˙876˙131 €
 EC max contribution 2˙876˙131 € (100%)
 Programme 1. H2020-EU.1.2.1. (FET Open)
 Code Call H2020-FETOPEN-2018-2019-2020-01
 Funding Scheme RIA
 Starting year 2019
 Duration (year-month-day) from 2019-10-01   to  2024-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TECHNISCHE UNIVERSITEIT EINDHOVEN NL (EINDHOVEN) coordinator 792˙500.00
2    UNIVERSITAETSKLINIKUM AACHEN DE (AACHEN) participant 831˙943.00
3    LIFETEC GROUP BV NL (EINDHOVEN) participant 451˙875.00
4    POLITECNICO DI MILANO IT (MILANO) participant 400˙000.00
5    NEMO HEALTHCARE BV NL (VELDHOVEN) participant 399˙812.00

Map

 Project objective

Every year, 800.000 babies are born extremely preterm (EP; <28 weeks of age) worldwide. A large proportion of survivors from this group of smallest infants face lifelong disabilities, including breathing, cardiac, neurological and metabolic problems. Current treatment requires the preterm initiation of body functions for which the respective organs are not prepared. This affects primarily the lungs which need to provide gas-exchange under air (i.e. oxygen-based mechanical ventilation), and the gut, which is needed for energy and nutrition. This approach causes major therapy-related morbidity such as bronchopulmonary dysplasia, necrotizing enterocolitis and germinal matrix bleeding. The Perinatal Life Support (PLS) consortium envisions a medical device that can support the safe development of EP infants outside the womb by preserving the innate fetal cardiorespiratory physiology ex vivo, with the following enabling technologies: 1. A liquid-based environment with oxygen and nutrient exchange using an ´artificial placenta´; 2. Continuous and non-invasive monitoring of fetal parameters such as heart rate and oxygenation; 3. Computational models for fast and objective clinical decision support based on physiological data input; 4. A fetal manikin that can accurately simulate EP infants in an intensive care setting. The PLS project will be carried out by an interdisciplinary group of academia and industry with experience in modelling, monitoring, engineering, obstetrics and neonatology. The technology underlying PLS is applicable to conditions where ex vivo life support is required e.g. organ perfusion, regeneration and transplantation. The integrated system will allow major progress towards translation for an urgent medical need, where new solutions are lacking as preclinical models are inadequate and clinical trials not feasible. Innovative simulation technology will enable technical validation of PLS, with demonstration of functionality in a final Proof-of-Principle.

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The information about "PLS" are provided by the European Opendata Portal: CORDIS opendata.

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lastchecktime (2020-10-27 21:15:26) correctly updated