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PLS SIGNED

Perinatal Life Support System: Integration of Enabling Technologies for Clinical Translation

Total Cost €

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EC-Contrib. €

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Partnership

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 PLS project word cloud

Explore the words cloud of the PLS project. It provides you a very rough idea of what is the project "PLS" about.

monitoring    proportion    physiology    lt    infants    bleeding    matrix    perinatal    prepared    obstetrics    gas    energy    bronchopulmonary    heart    extremely    womb    neurological    demonstration    metabolic    envisions    lungs    device    28    lifelong    data    placenta    worldwide    simulate    age    breathing    intensive    weeks    innovative    every    clinical    manikin    solutions    survivors    safe    acute    body    medical    vivo    final    preserving    decision    setting    group    respective    babies    cardiac    accurately    pls    born    trials    smallest    germinal    ep    mechanical    liquid    neonatology    causes    necrotizing    validation    treatment    life    functions    ex    urgent    applicable    inadequate    feasible    computational    air    regeneration    environment    lacking    cardiorespiratory    underlying    gut    initiation    oxygen    interdisciplinary    enterocolitis    morbidity    800    preterm    input    ventilation    disabilities    engineering    fetal    simulation    rate    nutrition    technologies    transplantation    innate    care    organ    primarily    physiological    exchange    translation    outside    invasive    continuous    organs    preclinical    dysplasia    oxygenation    progress    fast    academia    artificial    models    perfusion    industry    therapy    proof    nutrient   

Project "PLS" data sheet

The following table provides information about the project.

Coordinator
TECHNISCHE UNIVERSITEIT EINDHOVEN 

Organization address
address: GROENE LOPER 3
city: EINDHOVEN
postcode: 5612 AE
website: www.tue.nl/en

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 2˙876˙131 €
 EC max contribution 2˙876˙131 € (100%)
 Programme 1. H2020-EU.1.2.1. (FET Open)
 Code Call H2020-FETOPEN-2018-2019-2020-01
 Funding Scheme RIA
 Starting year 2019
 Duration (year-month-day) from 2019-10-01   to  2024-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TECHNISCHE UNIVERSITEIT EINDHOVEN NL (EINDHOVEN) coordinator 792˙500.00
2    UNIVERSITAETSKLINIKUM AACHEN DE (AACHEN) participant 831˙943.00
3    LIFETEC GROUP BV NL (EINDHOVEN) participant 451˙875.00
4    POLITECNICO DI MILANO IT (MILANO) participant 400˙000.00
5    NEMO HEALTHCARE BV NL (VELDHOVEN) participant 399˙812.00

Map

 Project objective

Every year, 800.000 babies are born extremely preterm (EP; <28 weeks of age) worldwide. A large proportion of survivors from this group of smallest infants face lifelong disabilities, including breathing, cardiac, neurological and metabolic problems. Current treatment requires the preterm initiation of body functions for which the respective organs are not prepared. This affects primarily the lungs which need to provide gas-exchange under air (i.e. oxygen-based mechanical ventilation), and the gut, which is needed for energy and nutrition. This approach causes major therapy-related morbidity such as bronchopulmonary dysplasia, necrotizing enterocolitis and germinal matrix bleeding. The Perinatal Life Support (PLS) consortium envisions a medical device that can support the safe development of EP infants outside the womb by preserving the innate fetal cardiorespiratory physiology ex vivo, with the following enabling technologies: 1. A liquid-based environment with oxygen and nutrient exchange using an ´artificial placenta´; 2. Continuous and non-invasive monitoring of fetal parameters such as heart rate and oxygenation; 3. Computational models for fast and objective clinical decision support based on physiological data input; 4. A fetal manikin that can accurately simulate EP infants in an intensive care setting. The PLS project will be carried out by an interdisciplinary group of academia and industry with experience in modelling, monitoring, engineering, obstetrics and neonatology. The technology underlying PLS is applicable to conditions where ex vivo life support is required e.g. organ perfusion, regeneration and transplantation. The integrated system will allow major progress towards translation for an urgent medical need, where new solutions are lacking as preclinical models are inadequate and clinical trials not feasible. Innovative simulation technology will enable technical validation of PLS, with demonstration of functionality in a final Proof-of-Principle.

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The information about "PLS" are provided by the European Opendata Portal: CORDIS opendata.

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