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MyeFattyLiver SIGNED

Unravelling the heterogeneity and functions of hepatic myeloid cells in Non-Alcoholic Fatty Liver Disease

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 MyeFattyLiver project word cloud

Explore the words cloud of the MyeFattyLiver project. It provides you a very rough idea of what is the project "MyeFattyLiver" about.

group    phenotypic    dendritic    vivo    fat    carcinoma    world    heterogeneity    ensuing    immune    health    alcoholic    contradictory    biggest    rna    nash    disease    fatty    functions    experimental    technologies    unclear    mononuclear    hepatocellular    heterogeneous    transplantation    macrophages    contributions    sensing    cell    inflammatory    non    date    depending    initiating    understand    population    genetic    steatohepatitis    mnp    dissecting    hypothesize    therapeutic    signals    facilitated    individual    mice    multiple    cirrhosis    mnps    cells    subtypes    cellular    lipids    progression    play    tools    progressing    accumulation    chronic    liver    predicted    western    danger    roles    revolutionised    single    hepatic    hits    types    phagocytes    strategies    countries    functional    men    ascribed    sequencing    excess    clinical    encompasses    nafld    activation    2030    excessive    burden    steatosis    myeloid    unravel    treatment    thought   

Project "MyeFattyLiver" data sheet

The following table provides information about the project.

Coordinator
VIB 

Organization address
address: RIJVISSCHESTRAAT 120
city: ZWIJNAARDE - GENT
postcode: 9052
website: www.vib.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-12-01   to  2024-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    VIB BE (ZWIJNAARDE - GENT) coordinator 1˙500˙000.00

Map

 Project objective

Non-alcoholic fatty liver disease (NAFLD) results from accumulation of excessive fat in the liver. It encompasses simple steatosis (fatty liver) progressing through non-alcoholic steatohepatitis (NASH), cirrhosis and hepatocellular carcinoma. It is the most common cause of chronic liver disease in western countries and is predicted to be the main cause of liver transplantation by 2030. As such NAFLD represents a significant clinical burden for which to date, there is no effective treatment. Multiple ‘hits’ are thought to contribute to the progression from steatosis to NASH. One of these ‘hits’ is activation of the immune system and the ensuing inflammatory response. Hepatic myeloid cells, including mononuclear phagocytes (MNPs) are thought to play an essential role in this, sensing excess lipids and other danger signals and initiating immune responses. However, MNPs represent a highly heterogeneous population, including multiple subtypes of dendritic cells and macrophages. To date these have been studied as a group rather than as individual cell types, leading to them being ascribed multiple and often contradictory roles depending on the experimental set up. Thus their specific contributions to NAFLD still remain unclear. I hypothesize that by dissecting the phenotypic and functional heterogeneity of hepatic MNPs, we will be able to unravel their roles in NAFLD and in the progression to NASH. Single cell technologies such as single cell RNA sequencing have revolutionised our ability to understand cellular heterogeneity. In addition, they have facilitated the development of novel genetic tools to study functions of specific cell types in vivo. I aim to use this technology and more specific in vivo tools to understand MNP phenotypic and functional heterogeneity in NAFLD in mice and men. This is essential for the development of novel therapeutic strategies targeting myeloid cells in what is becoming one of the biggest health challenges in the western world.

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