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MyeFattyLiver SIGNED

Unravelling the heterogeneity and functions of hepatic myeloid cells in Non-Alcoholic Fatty Liver Disease

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 MyeFattyLiver project word cloud

Explore the words cloud of the MyeFattyLiver project. It provides you a very rough idea of what is the project "MyeFattyLiver" about.

functions    facilitated    western    multiple    rna    steatohepatitis    liver    roles    lipids    macrophages    signals    cells    sequencing    excessive    cirrhosis    date    clinical    strategies    countries    phenotypic    burden    non    unclear    experimental    inflammatory    thought    tools    immune    population    therapeutic    hepatic    myeloid    hypothesize    treatment    ensuing    progression    accumulation    heterogeneous    types    danger    unravel    steatosis    contributions    mice    heterogeneity    nafld    understand    predicted    biggest    group    encompasses    depending    vivo    genetic    subtypes    hits    sensing    transplantation    disease    hepatocellular    mononuclear    health    progressing    functional    cell    chronic    dendritic    mnps    ascribed    alcoholic    fatty    play    revolutionised    cellular    initiating    single    nash    phagocytes    excess    world    contradictory    2030    activation    men    mnp    carcinoma    fat    technologies    individual    dissecting   

Project "MyeFattyLiver" data sheet

The following table provides information about the project.

Coordinator
VIB 

Organization address
address: RIJVISSCHESTRAAT 120
city: ZWIJNAARDE - GENT
postcode: 9052
website: www.vib.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-12-01   to  2024-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    VIB BE (ZWIJNAARDE - GENT) coordinator 1˙500˙000.00

Map

 Project objective

Non-alcoholic fatty liver disease (NAFLD) results from accumulation of excessive fat in the liver. It encompasses simple steatosis (fatty liver) progressing through non-alcoholic steatohepatitis (NASH), cirrhosis and hepatocellular carcinoma. It is the most common cause of chronic liver disease in western countries and is predicted to be the main cause of liver transplantation by 2030. As such NAFLD represents a significant clinical burden for which to date, there is no effective treatment. Multiple ‘hits’ are thought to contribute to the progression from steatosis to NASH. One of these ‘hits’ is activation of the immune system and the ensuing inflammatory response. Hepatic myeloid cells, including mononuclear phagocytes (MNPs) are thought to play an essential role in this, sensing excess lipids and other danger signals and initiating immune responses. However, MNPs represent a highly heterogeneous population, including multiple subtypes of dendritic cells and macrophages. To date these have been studied as a group rather than as individual cell types, leading to them being ascribed multiple and often contradictory roles depending on the experimental set up. Thus their specific contributions to NAFLD still remain unclear. I hypothesize that by dissecting the phenotypic and functional heterogeneity of hepatic MNPs, we will be able to unravel their roles in NAFLD and in the progression to NASH. Single cell technologies such as single cell RNA sequencing have revolutionised our ability to understand cellular heterogeneity. In addition, they have facilitated the development of novel genetic tools to study functions of specific cell types in vivo. I aim to use this technology and more specific in vivo tools to understand MNP phenotypic and functional heterogeneity in NAFLD in mice and men. This is essential for the development of novel therapeutic strategies targeting myeloid cells in what is becoming one of the biggest health challenges in the western world.

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The information about "MYEFATTYLIVER" are provided by the European Opendata Portal: CORDIS opendata.

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