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MyeFattyLiver SIGNED

Unravelling the heterogeneity and functions of hepatic myeloid cells in Non-Alcoholic Fatty Liver Disease

Total Cost €


EC-Contrib. €






 MyeFattyLiver project word cloud

Explore the words cloud of the MyeFattyLiver project. It provides you a very rough idea of what is the project "MyeFattyLiver" about.

activation    sequencing    countries    play    unravel    therapeutic    carcinoma    transplantation    hepatic    heterogeneity    technologies    disease    encompasses    unclear    thought    2030    ascribed    burden    predicted    group    health    heterogeneous    roles    phenotypic    types    mnp    contradictory    multiple    contributions    clinical    men    steatohepatitis    depending    cells    phagocytes    cirrhosis    progression    immune    experimental    mnps    nash    excess    functional    western    genetic    fat    cellular    initiating    functions    fatty    facilitated    progressing    population    dissecting    liver    non    date    sensing    dendritic    revolutionised    treatment    excessive    chronic    cell    strategies    rna    steatosis    individual    macrophages    tools    mice    danger    inflammatory    world    hits    signals    ensuing    alcoholic    accumulation    vivo    hepatocellular    single    myeloid    lipids    understand    subtypes    hypothesize    biggest    mononuclear    nafld   

Project "MyeFattyLiver" data sheet

The following table provides information about the project.


Organization address
postcode: 9052

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-12-01   to  2024-11-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    VIB BE (ZWIJNAARDE - GENT) coordinator 1˙500˙000.00


 Project objective

Non-alcoholic fatty liver disease (NAFLD) results from accumulation of excessive fat in the liver. It encompasses simple steatosis (fatty liver) progressing through non-alcoholic steatohepatitis (NASH), cirrhosis and hepatocellular carcinoma. It is the most common cause of chronic liver disease in western countries and is predicted to be the main cause of liver transplantation by 2030. As such NAFLD represents a significant clinical burden for which to date, there is no effective treatment. Multiple ‘hits’ are thought to contribute to the progression from steatosis to NASH. One of these ‘hits’ is activation of the immune system and the ensuing inflammatory response. Hepatic myeloid cells, including mononuclear phagocytes (MNPs) are thought to play an essential role in this, sensing excess lipids and other danger signals and initiating immune responses. However, MNPs represent a highly heterogeneous population, including multiple subtypes of dendritic cells and macrophages. To date these have been studied as a group rather than as individual cell types, leading to them being ascribed multiple and often contradictory roles depending on the experimental set up. Thus their specific contributions to NAFLD still remain unclear. I hypothesize that by dissecting the phenotypic and functional heterogeneity of hepatic MNPs, we will be able to unravel their roles in NAFLD and in the progression to NASH. Single cell technologies such as single cell RNA sequencing have revolutionised our ability to understand cellular heterogeneity. In addition, they have facilitated the development of novel genetic tools to study functions of specific cell types in vivo. I aim to use this technology and more specific in vivo tools to understand MNP phenotypic and functional heterogeneity in NAFLD in mice and men. This is essential for the development of novel therapeutic strategies targeting myeloid cells in what is becoming one of the biggest health challenges in the western world.

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