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MyeFattyLiver SIGNED

Unravelling the heterogeneity and functions of hepatic myeloid cells in Non-Alcoholic Fatty Liver Disease

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 MyeFattyLiver project word cloud

Explore the words cloud of the MyeFattyLiver project. It provides you a very rough idea of what is the project "MyeFattyLiver" about.

2030    biggest    western    dissecting    mnps    signals    men    roles    hepatic    tools    inflammatory    phenotypic    countries    world    unclear    hepatocellular    progressing    phagocytes    fatty    progression    lipids    vivo    fat    cirrhosis    facilitated    mononuclear    single    predicted    carcinoma    chronic    mnp    individual    immune    encompasses    genetic    nafld    heterogeneous    clinical    non    cellular    heterogeneity    excess    mice    liver    contradictory    depending    thought    health    experimental    ensuing    strategies    technologies    myeloid    disease    excessive    subtypes    multiple    burden    therapeutic    initiating    contributions    unravel    functional    revolutionised    activation    hypothesize    sequencing    ascribed    transplantation    understand    cells    nash    date    dendritic    alcoholic    group    macrophages    functions    cell    population    play    sensing    accumulation    hits    treatment    steatosis    danger    types    rna    steatohepatitis   

Project "MyeFattyLiver" data sheet

The following table provides information about the project.

Coordinator
VIB 

Organization address
address: RIJVISSCHESTRAAT 120
city: ZWIJNAARDE - GENT
postcode: 9052
website: www.vib.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-12-01   to  2024-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    VIB BE (ZWIJNAARDE - GENT) coordinator 1˙500˙000.00

Map

 Project objective

Non-alcoholic fatty liver disease (NAFLD) results from accumulation of excessive fat in the liver. It encompasses simple steatosis (fatty liver) progressing through non-alcoholic steatohepatitis (NASH), cirrhosis and hepatocellular carcinoma. It is the most common cause of chronic liver disease in western countries and is predicted to be the main cause of liver transplantation by 2030. As such NAFLD represents a significant clinical burden for which to date, there is no effective treatment. Multiple ‘hits’ are thought to contribute to the progression from steatosis to NASH. One of these ‘hits’ is activation of the immune system and the ensuing inflammatory response. Hepatic myeloid cells, including mononuclear phagocytes (MNPs) are thought to play an essential role in this, sensing excess lipids and other danger signals and initiating immune responses. However, MNPs represent a highly heterogeneous population, including multiple subtypes of dendritic cells and macrophages. To date these have been studied as a group rather than as individual cell types, leading to them being ascribed multiple and often contradictory roles depending on the experimental set up. Thus their specific contributions to NAFLD still remain unclear. I hypothesize that by dissecting the phenotypic and functional heterogeneity of hepatic MNPs, we will be able to unravel their roles in NAFLD and in the progression to NASH. Single cell technologies such as single cell RNA sequencing have revolutionised our ability to understand cellular heterogeneity. In addition, they have facilitated the development of novel genetic tools to study functions of specific cell types in vivo. I aim to use this technology and more specific in vivo tools to understand MNP phenotypic and functional heterogeneity in NAFLD in mice and men. This is essential for the development of novel therapeutic strategies targeting myeloid cells in what is becoming one of the biggest health challenges in the western world.

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