Opendata, web and dolomites

MicroAdiPSChip SIGNED

Micro-Fat Tissue on Chip

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 MicroAdiPSChip project word cloud

Explore the words cloud of the MicroAdiPSChip project. It provides you a very rough idea of what is the project "MicroAdiPSChip" about.

data    whereas    recapitulating    simulate    expenditure    restore    microfluidic    pluripotent    incorporated    microenvironment    induce    disorders    combine    mechanistically    chemical    outside    leads    burn    reserve    expansion    natural    laboratory    adipocytes    architectural    inducible    mature    imbalance    adipose    differentiate    microenvironmental    cold    chip    longer    nbsp    subtypes    cells    stem    assembly    micrometers    patient    hipscs    beige    energy    clinical    of    obesity    cell    attractive    micro    bioprinting    dynamically    clinically    models    serve    experimental    technologies    treat    intake    times    treatments    differentiation    heat    white    single    divided    reveal    brown    store    niches    resolution    activate    sizes    obstacles    fat    niche    mechanical    tissue    understand    organisms    diabetes    acquired    lack    detection    maintenance    strategy    exposure    mobilize    active    human    integration    cures    generate    metabolically    tissues    situ    metabolic    platforms    exploited   

Project "MicroAdiPSChip" data sheet

The following table provides information about the project.

Coordinator
HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH 

Organization address
address: INGOLSTADTER LANDSTRASSE 1
city: NEUHERBERG
postcode: 85764
website: www.helmholtz-muenchen.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙775˙000 €
 EC max contribution 1˙775˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-COG
 Funding Scheme ERC-COG
 Starting year 2018
 Duration (year-month-day) from 2018-06-01   to  2023-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH DE (NEUHERBERG) coordinator 1˙775˙000.00

Map

 Project objective

Human fat tissue has evolved to serve as a major energy reserve. An imbalance between energy intake and expenditure leads to an expansion of adipose tissue. Maintenance of this energy imbalance over longer times leads to obesity and metabolic disorders such as type 2 diabetes, for which clinical cures are not yet available. Adipocytes are the main cell type within the adipose tissue and can be divided into white, beige, and brown subtypes. White adipocytes store and mobilize energy, whereas beige and brown adipocytes store and burn energy during cold exposure to generate heat. An attractive strategy to restore the energy imbalance and treat obesity is to activate or increase the number of beige adipocytes in white adipose tissue. The main research obstacles affecting our ability to induce beige adipocytes is our lack of laboratory test systems recapitulating the microenvironmental conditions of the adipose tissue. Therefore, this research project aims to develop adipose tissue models outside organisms in sizes of micrometers for studying the differentiation of human inducible pluripotent stem cells (hiPSCs) into mature adipocytes. For assembly of the micro-fat tissues, we combine microfluidic and bioprinting technologies. In particular, the integration of micro-fat tissue on microfluidic chip platforms will be exploited to dynamically control the chemical, cell architectural, and mechanical microenvironment of hiPSCs incorporated in the micro-fat tissue. With novel single-cell-resolution in situ detection systems, we will aim to reveal, which microenvironmental stem cell niche factors are required to differentiate hiPSCs into metabolically active beige adipocytes. The acquired experimental data will help to mechanistically understand the role of natural stem cell niches, determine how to simulate them under laboratory conditions and finally provide patient-specific, clinically relevant information for developing new cell-based treatments for obesity.

 Publications

year authors and title journal last update
List of publications.
2020 Julius Wiener, Daniel Kokotek, Simon Rosowski, Heiko Lickert, Matthias Meier
Preparation of single- and double-oligonucleotide antibody conjugates and their application for protein analytics
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-020-58238-6
Scientific Reports 10/1 2020-02-05

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "MICROADIPSCHIP" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "MICROADIPSCHIP" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

Life-Inspired (2019)

Life-inspired complex molecular systems controlled by enzymatic reaction networks

Read More  

Aware (2019)

Aiding Antibiotic Development with Deep Analysis of Resistance Evolution

Read More  

NanoPD_P (2020)

High throughput multiplexed trace-analyte screening for diagnostics applications

Read More