EU H2020 Project "MICROADIPSCHIP (Micro-Fat Tissue on Chip)": description, partecipants, costs and EC-fundings

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MicroAdiPSChip project word cloud

Explore the words cloud of the MicroAdiPSChip project. It provides you a very rough idea of what is the project "MicroAdiPSChip" about.

micrometers imbalance intake laboratory mobilize active activate exposure metabolic single stem integration energy acquired microenvironment bioprinting serve nbsp situ adipose longer clinically data beige pluripotent chemical assembly expenditure micro divided mechanistically detection attractive times platforms chip cells microfluidic models inducible recapitulating organisms maintenance obstacles induce experimental mechanical cures adipocytes tissue incorporated generate treat cold burn understand metabolically architectural technologies cell clinical dynamically white obesity subtypes resolution simulate reserve differentiation lack differentiate natural mature exploited restore sizes microenvironmental store strategy expansion treatments leads human hipscs whereas combine niche disorders of fat tissues niches outside patient heat diabetes reveal brown

Project "MicroAdiPSChip" data sheet

The following table provides information about the project.

Coordinator	HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH Organization address address: INGOLSTADTER LANDSTRASSE 1 city: NEUHERBERG postcode: 85764 website: www.helmholtz-muenchen.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Germany [DE]
Total cost	1˙775˙000 €
EC max contribution	1˙775˙000 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2017-COG
Funding Scheme	ERC-COG
Starting year	2018
Duration (year-month-day)	from 2018-06-01 to 2023-05-31

#	participants	country	role	EC contrib. [€]
1	HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH	DE (NEUHERBERG)	coordinator	1˙775˙000.00

HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH

DE (NEUHERBERG)

coordinator

1˙775˙000.00

Project objective

Human fat tissue has evolved to serve as a major energy reserve. An imbalance between energy intake and expenditure leads to an expansion of adipose tissue. Maintenance of this energy imbalance over longer times leads to obesity and metabolic disorders such as type 2 diabetes, for which clinical cures are not yet available. Adipocytes are the main cell type within the adipose tissue and can be divided into white, beige, and brown subtypes. White adipocytes store and mobilize energy, whereas beige and brown adipocytes store and burn energy during cold exposure to generate heat. An attractive strategy to restore the energy imbalance and treat obesity is to activate or increase the number of beige adipocytes in white adipose tissue. The main research obstacles affecting our ability to induce beige adipocytes is our lack of laboratory test systems recapitulating the microenvironmental conditions of the adipose tissue. Therefore, this research project aims to develop adipose tissue models outside organisms in sizes of micrometers for studying the differentiation of human inducible pluripotent stem cells (hiPSCs) into mature adipocytes. For assembly of the micro-fat tissues, we combine microfluidic and bioprinting technologies. In particular, the integration of micro-fat tissue on microfluidic chip platforms will be exploited to dynamically control the chemical, cell architectural, and mechanical microenvironment of hiPSCs incorporated in the micro-fat tissue. With novel single-cell-resolution in situ detection systems, we will aim to reveal, which microenvironmental stem cell niche factors are required to differentiate hiPSCs into metabolically active beige adipocytes. The acquired experimental data will help to mechanistically understand the role of natural stem cell niches, determine how to simulate them under laboratory conditions and finally provide patient-specific, clinically relevant information for developing new cell-based treatments for obesity.

Publications

List of publications.
year	authors and title	journal	last update
2020	Julius Wiener, Daniel Kokotek, Simon Rosowski, Heiko Lickert, Matthias Meier Preparation of single- and double-oligonucleotide antibody conjugates and their application for protein analytics published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-020-58238-6	Scientific Reports 10/1	2020-02-05

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