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MitoRepairosome SIGNED

Dissecting the mechanism of DNA repair in human mitochondria

Total Cost €


EC-Contrib. €






 MitoRepairosome project word cloud

Explore the words cloud of the MitoRepairosome project. It provides you a very rough idea of what is the project "MitoRepairosome" about.

insights    temporal    compartments    apurinic    genetic    localized    spatial    excision    cancer    pol    accepted    locations    human    endonuclease    mammalian    dividing    mechanistic    form    repaired    apyrimidinic    ligase    constant    mistakes    membrane    bound    base    repair    exo    aging    detected    catalytic    mtdna    weight    diseases    defense    oxidative    anchored    components    polymerase    damaging    skeletal    agents    stored    mutations    neurological    attack    lesions    proximity    becomes    instability    complete    organization    transport    subunit    phosphorylation    subjected    readily    assembly    mechanism    aptly    ape1    molecular    nucleus    repairosome    mitochondria    thein    exogenous    cells    structures    chain    composition    cardiovascular    persistence    complexes    lig3    copied    fundamental    muscular    mitochondrial    electron    normal    accessory    oxphos    damage    leads    disorders    oxygen    reactive    exog    inner    faithfully    byproducts    enzymes    ber    endogenous    close    gamma    species    dna    genomic    ros   

Project "MitoRepairosome" data sheet

The following table provides information about the project.


Organization address
address: UL. BAZYNSKIEGO 8
city: GDANSK
postcode: 80309

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Poland [PL]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2020
 Duration (year-month-day) from 2020-02-01   to  2025-01-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIWERSYTET GDANSKI PL (GDANSK) coordinator 1˙500˙000.00


 Project objective

In mammalian cells genetic information is stored in two compartments: in the nucleus and in the mitochondria. DNA in mitochondria (mtDNA), just like in theIn mammalian cells genetic information is stored in two locations: in the nucleus and in mitochondria. DNA in mitochondria, just like in the nucleus, must be faithfully copied and mistakes (i.e. mutations due to exogenous and endogenous DNA damaging agents) lead to formation of DNA lesions. Persistence of these DNA lesions leads to genomic instability and human diseases like cardiovascular, skeletal muscular and neurological disorders, cancer as well as normal aging process. Mitochondrial DNA (mtDNA) is anchored to the inner mitochondrial membrane thus is in a close proximity to the electron transport chain and is subjected to a constant attack by reactive oxygen species (ROS), generated as byproducts of oxidative phosphorylation (OXPHOS). As a result mitochondria must have a robust DNA repair mechanism which becomes particularly important in non-dividing cells. It is accepted that DNA base excision repair (BER) pathway is a major defense mechanism against oxidative damage in human mitochondria. Aptly localized on mitochondrial inner membrane, mitochondrial BER enzymes: catalytic subunit of DNA polymerase γ (PolγA) along with its accessory subunit, DNA polymerase γ (PolγB), inner-membrane 5'-exo/endonuclease (EXOG), Apurinic/apyrimidinic endonuclease 1 (APE1) and Ligase 3 (Lig3) form a membrane-bound, high molecular weight, complexes called “mitochondrial repairosome”, capable of carrying out complete DNA repair. Although BER can be readily detected in mitochondria and major components have been identified, the spatial-temporal organization of mitochondrial repairosome and molecular mechanism by which mtDNA is repaired is not well understood. The goal of this research project is to provide fundamental mechanistic insights into the assembly, composition, activities and structures of human mitochondrial repairosome.

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The information about "MITOREPAIROSOME" are provided by the European Opendata Portal: CORDIS opendata.

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