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InterTAU SIGNED

Integrative structural biology of pathological tau protein, an appealing therapeutic target for Alzheimer´s disease modifying drugs

Total Cost €

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EC-Contrib. €

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Partnership

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InterTAU project word cloud

Explore the words cloud of the InterTAU project. It provides you a very rough idea of what is the project "InterTAU" about.

cellular characterization cutting innovation conformational solution alzheimer north prevention electron inducers cryo pursuing pathological argentina foundation pharma company efficient suitable tauopathies unmet nuclear variants altered assembly oligomerization protein resonance toxicity pathogenesis america transfer bioinformatics biotech enormous mutual microscopy biotechnological lacking envisaged magnetic solid functional pharmacological complementary denominator assembled academic forms oligomeric diagnosis translated modifying ad fibrillar immunotherapy pathology anti monomeric course structural clinical deeper therapy sharing stage assays biophysical nmr transferred molecular there platform therapies disease outcome conformationally edge hampered tau relates sustainable corroborated ing expertise cooperation intertau medical

Project "InterTAU" data sheet

The following table provides information about the project.

Coordinator	Masarykova univerzita Organization address address: Zerotinovo namesti 9 city: BRNO STRED postcode: 60177 website: http://www.muni.cz contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Czech Republic [CZ]
Total cost	1˙062˙600 €
EC max contribution	1˙058˙000 € (100%)
Programme	1. H2020-EU.1.3.3. (Stimulating innovation by means of cross-fertilisation of knowledge)
Code Call	H2020-MSCA-RISE-2019
Funding Scheme	MSCA-RISE
Starting year	2020
Duration (year-month-day)	from 2020-01-01 to 2023-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	Masarykova univerzita Masarykova univerzita Organization address address: Zerotinovo namesti 9 city: BRNO STRED postcode: 60177 website: http://www.muni.cz contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CZ (BRNO STRED)	coordinator	441˙600.00
2	AXON NEUROSCIENCE R&D SERVICES SE AXON NEUROSCIENCE R&D SERVICES SE Organization address address: DVORAKOVO NABREZIE 10 city: BRATISLAVA postcode: 811 02 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SK (BRATISLAVA)	participant	464˙600.00
3	LATVIJAS ORGANISKAS SINTEZES INSTITUTS LATVIJAS ORGANISKAS SINTEZES INSTITUTS Organization address address: AIZKRAUKLES 21 city: RIGA postcode: 1006 website: www.osi.lv contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	LV (RIGA)	participant	128˙800.00
4	ROYAL COLLEGE OF SURGEONS IN IRELAND ROYAL COLLEGE OF SURGEONS IN IRELAND Organization address address: Saint Stephen's Green 123 city: DUBLIN postcode: 2 website: www.rcsi.ie contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IE (DUBLIN)	participant	23˙000.00
5	OREGON STATE UNIVERSITY OREGON STATE UNIVERSITY Organization address address: 312 KERR ADMIN BLDG city: CORVALLIS postcode: 97331 2140 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (CORVALLIS)	partner	0.00
6	UNIVERSIDAD NACIONAL DE CUYO UNIVERSIDAD NACIONAL DE CUYO Organization address address: PARQUE GENERAL SAN MARTIN S/N city: MENDOZA postcode: 5500 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AR (MENDOZA)	partner	0.00
7	UNIVERSITY HEALTH NETWORK UNIVERSITY HEALTH NETWORK Organization address address: 190 ELIZABETH STREET city: TORONTO postcode: M5G2C4 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CA (TORONTO)	partner	0.00
8	UNIVERSITY OF PITTSBURGH UNIVERSITY OF PITTSBURGH Organization address address: University Place 123 city: PITTSBURGH postcode: 15213 website: www.pitt.edu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (PITTSBURGH)	partner	0.00

Map

Project objective

There is an enormous and unmet medical need to find efficient methods of prevention, diagnosis and disease-modifying therapies for tauopathies, including Alzheimer’s disease. The common molecular denominator of tauopathies are pathological forms of tau protein. Tau pathology relates to conformational changes during oligomerization and assembly resulting in toxicity. Given its role in the pathogenesis, conformationally altered and assembled tau would be a promising molecular target for disease-modifying therapy. However, the field is still lacking a deeper understanding of tau structural changes in the course of assembly and their inducers on the pathway towards the pathological forms of Tau; therefore, the pharma development is hampered. The main aim of the InterTau project is the detailed structural and biophysical characterization of tau protein and its variants in monomeric, oligomeric and fibrillar states relevant for AD and other tauopathies. The InterTAU consortium is composed of a clinical-stage biotech company pursuing development of anti-tau immunotherapy and academic partners with cutting-edge methodologies suitable for functional and structural characterization of the tau assembly pathway by solution and solid-state nuclear magnetic resonance (NMR), cryo-electron microscopy and cellular assays corroborated by bioinformatics. The mutual transfer of complementary expertise envisaged in the project will facilitate academic outcome and biotechnological development. Specific expertise will be transferred from three institutions in North America and one institution from Argentina. The results of InterTAU will be directly translated into innovation in pharmacological development through the non-academic partner. The platform for sharing knowledge will be a foundation of sustainable cooperation beyond the InterTau project.

Deliverables

List of deliverables.
Project website	Websites, patent fillings, videos etc.	2020-04-03 12:46:44

Take a look to the deliverables list in detail: detailed list of InterTAU deliverables.

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The information about "INTERTAU" are provided by the European Opendata Portal: CORDIS opendata.

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