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InterTAU SIGNED

Integrative structural biology of pathological tau protein, an appealing therapeutic target for Alzheimer´s disease modifying drugs

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 InterTAU project word cloud

Explore the words cloud of the InterTAU project. It provides you a very rough idea of what is the project "InterTAU" about.

cutting    electron    there    stage    variants    pathological    argentina    america    envisaged    pharma    solution    anti    tauopathies    ing    solid    suitable    cryo    efficient    cellular    company    assembled    outcome    tau    modifying    prevention    lacking    relates    magnetic    nuclear    altered    denominator    microscopy    pursuing    foundation    transferred    oligomerization    complementary    alzheimer    biotech    biotechnological    enormous    therapies    forms    fibrillar    protein    bioinformatics    pathology    intertau    assembly    molecular    unmet    nmr    translated    oligomeric    resonance    clinical    functional    inducers    disease    monomeric    cooperation    conformationally    ad    pharmacological    corroborated    north    biophysical    hampered    conformational    immunotherapy    mutual    toxicity    expertise    structural    innovation    sustainable    transfer    edge    therapy    sharing    platform    deeper    course    diagnosis    characterization    assays    academic    medical    pathogenesis   

Project "InterTAU" data sheet

The following table provides information about the project.

Coordinator
Masarykova univerzita 

Organization address
address: Zerotinovo namesti 9
city: BRNO STRED
postcode: 60177
website: http://www.muni.cz

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Czech Republic [CZ]
 Total cost 1˙062˙600 €
 EC max contribution 1˙058˙000 € (100%)
 Programme 1. H2020-EU.1.3.3. (Stimulating innovation by means of cross-fertilisation of knowledge)
 Code Call H2020-MSCA-RISE-2019
 Funding Scheme MSCA-RISE
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    Masarykova univerzita CZ (BRNO STRED) coordinator 441˙600.00
2    AXON NEUROSCIENCE R&D SERVICES SE SK (BRATISLAVA) participant 464˙600.00
3    LATVIJAS ORGANISKAS SINTEZES INSTITUTS LV (RIGA) participant 128˙800.00
4    ROYAL COLLEGE OF SURGEONS IN IRELAND IE (DUBLIN) participant 23˙000.00
5    OREGON STATE UNIVERSITY US (CORVALLIS) partner 0.00
6    UNIVERSIDAD NACIONAL DE CUYO AR (MENDOZA) partner 0.00
7    UNIVERSITY HEALTH NETWORK CA (TORONTO) partner 0.00
8    UNIVERSITY OF PITTSBURGH US (PITTSBURGH) partner 0.00

Map

 Project objective

There is an enormous and unmet medical need to find efficient methods of prevention, diagnosis and disease-modifying therapies for tauopathies, including Alzheimer’s disease. The common molecular denominator of tauopathies are pathological forms of tau protein. Tau pathology relates to conformational changes during oligomerization and assembly resulting in toxicity. Given its role in the pathogenesis, conformationally altered and assembled tau would be a promising molecular target for disease-modifying therapy. However, the field is still lacking a deeper understanding of tau structural changes in the course of assembly and their inducers on the pathway towards the pathological forms of Tau; therefore, the pharma development is hampered. The main aim of the InterTau project is the detailed structural and biophysical characterization of tau protein and its variants in monomeric, oligomeric and fibrillar states relevant for AD and other tauopathies. The InterTAU consortium is composed of a clinical-stage biotech company pursuing development of anti-tau immunotherapy and academic partners with cutting-edge methodologies suitable for functional and structural characterization of the tau assembly pathway by solution and solid-state nuclear magnetic resonance (NMR), cryo-electron microscopy and cellular assays corroborated by bioinformatics. The mutual transfer of complementary expertise envisaged in the project will facilitate academic outcome and biotechnological development. Specific expertise will be transferred from three institutions in North America and one institution from Argentina. The results of InterTAU will be directly translated into innovation in pharmacological development through the non-academic partner. The platform for sharing knowledge will be a foundation of sustainable cooperation beyond the InterTau project.

 Deliverables

List of deliverables.
Project website Websites, patent fillings, videos etc. 2020-04-03 12:46:44

Take a look to the deliverables list in detail:  detailed list of InterTAU deliverables.

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