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HDM-FUN SIGNED

Host directed medicine in invasive fungal infection

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 HDM-FUN project word cloud

Explore the words cloud of the HDM-FUN project. It provides you a very rough idea of what is the project "HDM-FUN" about.

point    modulators    diagnostic    options    morbidity    explore    clinical    metabolomics    interventions    medicine    preventive    experts    translate    microbiome    tools    teaching    despite    efforts    care    outcome    inflammasome    managed    unacceptably    immunology    observational    intensive    disease    mortality    patients    susceptibility    influenza    tests    aspergillosis    metabolome    experimental    directed    biogenesis    infections    proposes    pathogen    interactions    genetics    strategies    fungal    unravel    enrolled    invasive    hdm    transdisciplinary    designing    health    medical    infection    protocols    believe    trial    fun    centrally    scientists    trials    stratify    centralize    first    treatment    biobank    hpfs    candidemia    brings    signalling    overcome    standardize    lethal    setting    therapeutic    ifi    correlate    host    personalized    transcription    infrastructure    prospective    prophylaxis    professionals    immunotherapy    regulation    samples    immune    risk    phagosome   

Project "HDM-FUN" data sheet

The following table provides information about the project.

Coordinator
STICHTING KATHOLIEKE UNIVERSITEIT 

Organization address
address: GEERT GROOTEPLEIN NOORD 9
city: NIJMEGEN
postcode: 6525 EZ
website: www.radboudumc.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 10˙158˙439 €
 EC max contribution 9˙998˙170 € (98%)
 Programme 1. H2020-EU.3.1.3. (Treating and managing disease)
 Code Call H2020-SC1-2019-Two-Stage-RTD
 Funding Scheme RIA
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2024-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    STICHTING KATHOLIEKE UNIVERSITEIT NL (NIJMEGEN) coordinator 2˙811˙150.00
2    IMAGINE INSTITUT DES MALADIES GENETIQUES NECKER ENFANTS MALADES FONDATION FR (PARIS 15) participant 1˙220˙750.00
3    CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS CH (LAUSANNE) participant 703˙000.00
4    INSTITUT PASTEUR FR (PARIS CEDEX 15) participant 692˙185.00
5    KATHOLIEKE UNIVERSITEIT LEUVEN BE (LEUVEN) participant 684˙000.00
6    DUKE UNIVERSITY US (DURHAM NC) participant 592˙750.00
7    Hycult biotechnology bv NL (Uden) participant 400˙000.00
8    INNOVATION ACTA S.R.L. IT (ROMA) participant 350˙500.00
9    JOHANN WOLFGANG GOETHE-UNIVERSITATFRANKFURT AM MAIN DE (FRANKFURT AM MAIN) participant 345˙750.00
10    UNIVERSITA DEGLI STUDI DI PERUGIA IT (PERUGIA) participant 322˙450.00
11    THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN UK (ABERDEEN) participant 320˙010.00
12    JULIUS-MAXIMILIANS-UNIVERSITAT WURZBURG DE (WUERZBURG) participant 319˙950.00
13    IDRYMA TECHNOLOGIAS KAI EREVNAS EL (IRAKLEIO) participant 319˙750.00
14    LEIBNIZ-INSTITUT FUR NATURSTOFF-FORSCHUNG UND INFEKTIONSBIOLOGIE EV HANS-KNOLL-ISTITUT DE (JENA) participant 319˙700.00
15    UNIVERSIDADE DO MINHO PT (BRAGA) participant 319˙625.00
16    UNIVERSITATEA DE MEDICINA SI FARMACIE IULIU HATIEGANU CLUJ-NAPOCA RO (Cluj-Napoca) participant 276˙600.00

Map

 Project objective

Despite novel treatment options and development of diagnostic tools invasive fungal infections (IFI) are still associated with an unacceptably high mortality and morbidity. Experts believe that a host directed approach is needed to overcome this problem. HDM-FUN proposes a transdisciplinary approach to identify host-pathogen factors (HPFs) needed for host directed medical interventions in IFI and will be the first of its kind. The overall concept is to identify host-pathogen factors in the setting of immunotherapy and prophylaxis that will allow the design for tailored novel therapeutic and preventive host-directed medicine approaches for patients with lethal invasive fungal infection in the intensive care. Specific objectives: 1. To identify host-pathogen factors that correlate with disease, and correlate them with preventive or immunotherapy- based strategies to stratify patients for personalized host-directed treatment options. 2. Two clinical trials of host-directed medicine approaches; an immunotherapy trial in patients with candidemia and a prospective observational trial for prophylaxis in patients with influenza at risk for aspergillosis. 3. To set-up a centrally managed biobank with samples of the patients enrolled in both clinical trials, and to standardize experimental procedures, protocols and centralize analysis. 4. To establish a unique infrastructure aimed to: explore host-directed medicine approaches in IFI, evaluate their impact on patients and health care, translate research efforts to clinical practice by designing point of care tests and teaching medical professionals. HDM-FUN brings together top scientists and clinical researchers to unravel host factors (genetics and transcription), immune modulators (metabolome, microbiome), and host pathogen interactions (genetics, metabolomics, immunology, signalling pathways, phagosome biogenesis, and inflammasome regulation) that determine the susceptibility and outcome of patients with fungal infection.

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The information about "HDM-FUN" are provided by the European Opendata Portal: CORDIS opendata.

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