Explore the words cloud of the HDM-FUN project. It provides you a very rough idea of what is the project "HDM-FUN" about.
The following table provides information about the project.
STICHTING KATHOLIEKE UNIVERSITEIT
|Coordinator Country||Netherlands [NL]|
|Total cost||10˙158˙439 €|
|EC max contribution||9˙998˙170 € (98%)|
1. H2020-EU.3.1.3. (Treating and managing disease)
|Duration (year-month-day)||from 2020-01-01 to 2024-12-31|
Take a look of project's partnership.
|1||STICHTING KATHOLIEKE UNIVERSITEIT||NL (NIJMEGEN)||coordinator||2˙811˙150.00|
|2||IMAGINE INSTITUT DES MALADIES GENETIQUES NECKER ENFANTS MALADES FONDATION||FR (PARIS 15)||participant||1˙220˙750.00|
|3||CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS||CH (LAUSANNE)||participant||703˙000.00|
|4||INSTITUT PASTEUR||FR (PARIS CEDEX 15)||participant||692˙185.00|
|5||KATHOLIEKE UNIVERSITEIT LEUVEN||BE (LEUVEN)||participant||684˙000.00|
|6||DUKE UNIVERSITY||US (DURHAM NC)||participant||592˙750.00|
|7||Hycult biotechnology bv||NL (Uden)||participant||400˙000.00|
|8||INNOVATION ACTA S.R.L.||IT (ROMA)||participant||350˙500.00|
|9||JOHANN WOLFGANG GOETHE-UNIVERSITATFRANKFURT AM MAIN||DE (FRANKFURT AM MAIN)||participant||345˙750.00|
|10||UNIVERSITA DEGLI STUDI DI PERUGIA||IT (PERUGIA)||participant||322˙450.00|
|11||THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN||UK (ABERDEEN)||participant||320˙010.00|
|12||JULIUS-MAXIMILIANS-UNIVERSITAT WURZBURG||DE (WUERZBURG)||participant||319˙950.00|
|13||IDRYMA TECHNOLOGIAS KAI EREVNAS||EL (IRAKLEIO)||participant||319˙750.00|
|14||LEIBNIZ-INSTITUT FUR NATURSTOFF-FORSCHUNG UND INFEKTIONSBIOLOGIE EV HANS-KNOLL-ISTITUT||DE (JENA)||participant||319˙700.00|
|15||UNIVERSIDADE DO MINHO||PT (BRAGA)||participant||319˙625.00|
|16||UNIVERSITATEA DE MEDICINA SI FARMACIE IULIU HATIEGANU CLUJ-NAPOCA||RO (Cluj-Napoca)||participant||276˙600.00|
Despite novel treatment options and development of diagnostic tools invasive fungal infections (IFI) are still associated with an unacceptably high mortality and morbidity. Experts believe that a host directed approach is needed to overcome this problem. HDM-FUN proposes a transdisciplinary approach to identify host-pathogen factors (HPFs) needed for host directed medical interventions in IFI and will be the first of its kind. The overall concept is to identify host-pathogen factors in the setting of immunotherapy and prophylaxis that will allow the design for tailored novel therapeutic and preventive host-directed medicine approaches for patients with lethal invasive fungal infection in the intensive care. Specific objectives: 1. To identify host-pathogen factors that correlate with disease, and correlate them with preventive or immunotherapy- based strategies to stratify patients for personalized host-directed treatment options. 2. Two clinical trials of host-directed medicine approaches; an immunotherapy trial in patients with candidemia and a prospective observational trial for prophylaxis in patients with influenza at risk for aspergillosis. 3. To set-up a centrally managed biobank with samples of the patients enrolled in both clinical trials, and to standardize experimental procedures, protocols and centralize analysis. 4. To establish a unique infrastructure aimed to: explore host-directed medicine approaches in IFI, evaluate their impact on patients and health care, translate research efforts to clinical practice by designing point of care tests and teaching medical professionals. HDM-FUN brings together top scientists and clinical researchers to unravel host factors (genetics and transcription), immune modulators (metabolome, microbiome), and host pathogen interactions (genetics, metabolomics, immunology, signalling pathways, phagosome biogenesis, and inflammasome regulation) that determine the susceptibility and outcome of patients with fungal infection.
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The information about "HDM-FUN" are provided by the European Opendata Portal: CORDIS opendata.
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