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Opendata, web and dolomites

HDM-FUN SIGNED

Host directed medicine in invasive fungal infection

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

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HDM-FUN project word cloud

Explore the words cloud of the HDM-FUN project. It provides you a very rough idea of what is the project "HDM-FUN" about.

phagosome fun medicine patients despite fungal tools prospective outcome explore immune hpfs brings infections lethal centrally disease enrolled stratify experimental managed tests influenza host strategies biogenesis hdm health interactions invasive trials options overcome therapeutic transcription point prophylaxis protocols first signalling scientists modulators immunotherapy intensive infection genetics proposes translate centralize personalized morbidity candidemia believe samples teaching mortality inflammasome setting directed unravel metabolomics care susceptibility risk diagnostic pathogen transdisciplinary ifi trial microbiome metabolome experts treatment aspergillosis efforts observational interventions preventive correlate designing immunology regulation clinical infrastructure standardize professionals unacceptably biobank medical

Project "HDM-FUN" data sheet

The following table provides information about the project.

Coordinator	STICHTING KATHOLIEKE UNIVERSITEIT Organization address address: GEERT GROOTEPLEIN NOORD 9 city: NIJMEGEN postcode: 6525 EZ website: www.radboudumc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Netherlands [NL]
Total cost	10˙158˙439 €
EC max contribution	9˙998˙170 € (98%)
Programme	1. H2020-EU.3.1.3. (Treating and managing disease)
Code Call	H2020-SC1-2019-Two-Stage-RTD
Funding Scheme	RIA
Starting year	2020
Duration (year-month-day)	from 2020-01-01 to 2024-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	STICHTING KATHOLIEKE UNIVERSITEIT STICHTING KATHOLIEKE UNIVERSITEIT Organization address address: GEERT GROOTEPLEIN NOORD 9 city: NIJMEGEN postcode: 6525 EZ website: www.radboudumc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (NIJMEGEN)	coordinator	2˙811˙150.00
2	IMAGINE INSTITUT DES MALADIES GENETIQUES NECKER ENFANTS MALADES FONDATION IMAGINE INSTITUT DES MALADIES GENETIQUES NECKER ENFANTS MALADES FONDATION Organization address address: 24 BD DU MONTPARNASSE city: PARIS 15 postcode: 75015 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS 15)	participant	1˙220˙750.00
3	CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS Organization address address: RUE DU BUGNON 21 city: LAUSANNE postcode: 1011 website: www.chuv.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (LAUSANNE)	participant	703˙000.00
4	INSTITUT PASTEUR INSTITUT PASTEUR Organization address address: RUE DU DOCTEUR ROUX 25-28 city: PARIS CEDEX 15 postcode: 75724 website: http://www.pasteur.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS CEDEX 15)	participant	692˙185.00
5	KATHOLIEKE UNIVERSITEIT LEUVEN KATHOLIEKE UNIVERSITEIT LEUVEN Organization address address: OUDE MARKT 13 city: LEUVEN postcode: 3000 website: www.kuleuven.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (LEUVEN)	participant	684˙000.00
6	DUKE UNIVERSITY DUKE UNIVERSITY Organization address address: ALLEN BUILDING 207 city: DURHAM NC postcode: 27708 website: www.duke.edu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (DURHAM NC)	participant	592˙750.00
7	Hycult biotechnology bv Hycult biotechnology bv Organization address address: Frontstraat 2A city: Uden postcode: 5405 PB website: www.hbt.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (Uden)	participant	400˙000.00
8	INNOVATION ACTA S.R.L. INNOVATION ACTA S.R.L. Organization address address: VIA D.A. AZUNI, 9 city: ROMA postcode: 196 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (ROMA)	participant	350˙500.00
9	JOHANN WOLFGANG GOETHE-UNIVERSITATFRANKFURT AM MAIN JOHANN WOLFGANG GOETHE-UNIVERSITATFRANKFURT AM MAIN Organization address address: THEODOR W ADORNO PLATZ 1 city: FRANKFURT AM MAIN postcode: 60323 website: www.uni-frankfurt.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (FRANKFURT AM MAIN)	participant	345˙750.00
10	UNIVERSITA DEGLI STUDI DI PERUGIA UNIVERSITA DEGLI STUDI DI PERUGIA Organization address address: PIAZZA DELL UNIVERSITA 1 city: PERUGIA postcode: 6123 website: www.unipg.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (PERUGIA)	participant	322˙450.00
11	THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN Organization address address: KING'S COLLEGE REGENT WALK city: ABERDEEN postcode: AB24 3FX website: http://www.abdn.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (ABERDEEN)	participant	320˙010.00
12	JULIUS-MAXIMILIANS-UNIVERSITAT WURZBURG JULIUS-MAXIMILIANS-UNIVERSITAT WURZBURG Organization address address: SANDERRING 2 city: WUERZBURG postcode: 97070 website: http://www.uni-wuerzburg.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (WUERZBURG)	participant	319˙950.00
13	IDRYMA TECHNOLOGIAS KAI EREVNAS IDRYMA TECHNOLOGIAS KAI EREVNAS Organization address address: N PLASTIRA STR 100 city: IRAKLEIO postcode: 70013 website: www.forth.gr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	EL (IRAKLEIO)	participant	319˙750.00
14	LEIBNIZ-INSTITUT FUR NATURSTOFF-FORSCHUNG UND INFEKTIONSBIOLOGIE EV HANS-KNOLL-ISTITUT LEIBNIZ-INSTITUT FUR NATURSTOFF-FORSCHUNG UND INFEKTIONSBIOLOGIE EV HANS-KNOLL-ISTITUT Organization address address: BEUTENBERG STRASSE 11A city: JENA postcode: 7745 website: http://www2.hki-jena.de/rz/hki_i00.htm contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (JENA)	participant	319˙700.00
15	UNIVERSIDADE DO MINHO UNIVERSIDADE DO MINHO Organization address address: LARGO DO PACO city: BRAGA postcode: 4704 553 website: www.uminho.pt contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PT (BRAGA)	participant	319˙625.00
16	UNIVERSITATEA DE MEDICINA SI FARMACIE IULIU HATIEGANU CLUJ-NAPOCA UNIVERSITATEA DE MEDICINA SI FARMACIE IULIU HATIEGANU CLUJ-NAPOCA Organization address address: VICTOR BABES STREET 8 city: Cluj-Napoca postcode: 400012 website: www.umfcluj.ro contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	RO (Cluj-Napoca)	participant	276˙600.00

Map

Project objective

Despite novel treatment options and development of diagnostic tools invasive fungal infections (IFI) are still associated with an unacceptably high mortality and morbidity. Experts believe that a host directed approach is needed to overcome this problem. HDM-FUN proposes a transdisciplinary approach to identify host-pathogen factors (HPFs) needed for host directed medical interventions in IFI and will be the first of its kind. The overall concept is to identify host-pathogen factors in the setting of immunotherapy and prophylaxis that will allow the design for tailored novel therapeutic and preventive host-directed medicine approaches for patients with lethal invasive fungal infection in the intensive care. Specific objectives: 1. To identify host-pathogen factors that correlate with disease, and correlate them with preventive or immunotherapy- based strategies to stratify patients for personalized host-directed treatment options. 2. Two clinical trials of host-directed medicine approaches; an immunotherapy trial in patients with candidemia and a prospective observational trial for prophylaxis in patients with influenza at risk for aspergillosis. 3. To set-up a centrally managed biobank with samples of the patients enrolled in both clinical trials, and to standardize experimental procedures, protocols and centralize analysis. 4. To establish a unique infrastructure aimed to: explore host-directed medicine approaches in IFI, evaluate their impact on patients and health care, translate research efforts to clinical practice by designing point of care tests and teaching medical professionals. HDM-FUN brings together top scientists and clinical researchers to unravel host factors (genetics and transcription), immune modulators (metabolome, microbiome), and host pathogen interactions (genetics, metabolomics, immunology, signalling pathways, phagosome biogenesis, and inflammasome regulation) that determine the susceptibility and outcome of patients with fungal infection.

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