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DocTIS SIGNED

DECISION ON OPTIMAL COMBINATORIAL THERAPIES IN IMIDS USING SYSTEMS APPROACHES

Total Cost €

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EC-Contrib. €

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Partnership

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Project "DocTIS" data sheet

The following table provides information about the project.

Coordinator
FUNDACIO HOSPITAL UNIVERSITARI VALL D'HEBRON - INSTITUT DE RECERCA 

Organization address
address: PASSEIG VALL D HEBRON 119-129 EDIFICIO DE RECERCA
city: BARCELONA
postcode: 8035
website: http://www.vhir.org/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 6˙260˙050 €
 EC max contribution 6˙260˙050 € (100%)
 Programme 1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease)
 Code Call H2020-SC1-2019-Two-Stage-RTD
 Funding Scheme RIA
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2025-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACIO HOSPITAL UNIVERSITARI VALL D'HEBRON - INSTITUT DE RECERCA ES (BARCELONA) coordinator 1˙122˙820.00
2    FUNDACIO CENTRE DE REGULACIO GENOMICA ES (BARCELONA) participant 1˙065˙750.00
3    LINKOPINGS UNIVERSITET SE (LINKOPING) participant 920˙045.00
4    CARDIFF UNIVERSITY UK (CARDIFF) participant 890˙412.00
5    CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER ES (BARCELONA) participant 575˙000.00
6    HUDSONALPHA INSTITUTE FOR BIOTECHNOLOGY US (HUNTSVILLE) participant 567˙317.00
7    IMIDOMICS SL ES (BARCELONA) participant 366˙655.00
8    CHARITE - UNIVERSITAETSMEDIZIN BERLIN DE (BERLIN) participant 251˙250.00
9    UNIVERSITA DEGLI STUDI DI VERONA IT (VERONA) participant 251˙231.00
10    ZABALA INNOVATION CONSULTING, S.A. ES (MUTILVA ALTA NAVARRA) participant 249˙568.00

Map

 Project objective

Immune-Mediated Inflammatory Diseases (IMIDs) are a group of common autoimmune diseases that include clinically heterogeneous disorders such as rheumatoid arthritis, psoriasis, psoriatic arthritis, Crohn’s disease, ulcerative colitis and systemic lupus erythematosus. Despite their clinical heterogeneity, IMIDs share a significant number of features at the molecular and cellular levels. Recently developed therapies targeting common key molecules of the immune system like anti-TNF agents, have collectively resulted in a significant improvement in the management of IMIDs. Still, the complete control of the chronic inflammatory process is rarely attained, and too many patients experience a poor response, if at all. This inefficacy has become a major economic burden and severely impacts on the wellbeing of many European citizens. The DocTIS projects aims to profoundly change this trend by identifying highly effective combinatorial therapies as well as the group of patients where this response will be optimal. Using the standardized samples from one of the world’s largest biobanks specialized in IMIDs, new molecular data will be generated using advanced high-throughput technologies including single cell RNA-seq. Systems biology methods will be applied to this unique clinical and molecular data to model the response to targeted therapies and predict what drug combinations will act synergistically and on which types of patients. After validation in a preclinical stage, the optimal combinatorial therapy will be tested in a group of patients with a positive biomarker profile. Using a basket trial, a new type of clinical trial design that incorporates molecular marker information, the DocTIS project will provide proof of concept of the utility of combinatorial therapy and personalized medicine for the effective control of disease activity in IMIDs.

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The information about "DOCTIS" are provided by the European Opendata Portal: CORDIS opendata.

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