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CRUCIAL SIGNED

MiCrovasculaR rarefaction in vascUlar Cognitive Impairement and heArt faiLure

Total Cost €

0

EC-Contrib. €

0

Partnership

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Project "CRUCIAL" data sheet

The following table provides information about the project.

Coordinator
KATHOLIEKE UNIVERSITEIT LEUVEN 

Organization address
address: OUDE MARKT 13
city: LEUVEN
postcode: 3000
website: www.kuleuven.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 6˙000˙000 €
 EC max contribution 6˙000˙000 € (100%)
 Programme 1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease)
 Code Call H2020-SC1-2019-Two-Stage-RTD
 Funding Scheme RIA
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KATHOLIEKE UNIVERSITEIT LEUVEN BE (LEUVEN) coordinator 1˙340˙553.00
2    UNIVERSITEIT MAASTRICHT NL (MAASTRICHT) participant 1˙465˙843.00
3    UNIVERSITY COLLEGE LONDON UK (LONDON) participant 949˙470.00
4    VIB BE (ZWIJNAARDE - GENT) participant 777˙630.00
5    FUNDACION PARA LA INVESTIGACION MEDICA APLICADA FIMA ES (PAMPLONA) participant 459˙505.00
6    UNIVERSIDAD DE NAVARRA ES (PAMPLONA) participant 345˙495.00
7    ARTTIC FR (PARIS) participant 227˙250.00
8    GLYCOCHECK BV NL (SCHIMMERT) participant 133˙000.00
9    INLECOM INNOVATION ASTIKI MI KERDOSKOPIKI ETAIREIA EL (ATHINA) participant 131˙252.00
10    CROWDHELIX LIMITED IE (CORK) participant 130˙000.00
11    BRAINS UNLIMITED B.V. / TRADE NAME SCANNEXUS NL (MAASTRICHT) participant 20˙000.00
12    CARDIOMYOPATHY UK UK (CHESHAM) participant 20˙000.00

Map

 Project objective

Vascular dementia and heart failure represent major health burden to morbidity, mortality and quality of life. Comorbidities (hypertension, aging, diabetes, etc.) affect all organs, but the brain and heart are especially sensitive to these chronic stresses resulting in cognitive impairment (a mental disorder) and heart failure (a non-mental disorder). These comorbidities also induce a reduction in microvascular density, called microvascular rarefaction. We have build a consortium, CRUCIAL, which will develop a coordinated program to investigate the role of microvascular rarefaction in cognitive impairment and heart failure.

Diagnosis of microvascular rarefaction is limited by the inability to assess microvascular density. We will develop advanced imaging tools taking advantage of the newest MRI technology including non-contrast and artificial intelligence methods to assess brain and heart microvascular rarefaction. We will also develop other non-invasive measures that will be cheaper and easier to widely disseminate in clinical practice (sublingual and retinal microvascular imaging, and blood microvesicle analysis). We will then apply these techniques to prospective and retrospective patient cohorts with cognitive impairment and heart failure to demonstrate that rarefaction can be used as a biomarker to diagnose and stratify patients. Microvascular regression is now recognised as an active process. We will therefore investigate, through animal models, the molecular mechanism of vessel rarefaction in the presence of comorbidities that could be targeted therapeutically.

Therapeutic options for cognitive impairment or heart failure are currently limited to treating co-morbidities. The aim of CRUCUAL is to deliver diagnostic tools to clinician and therapeutic pathways to pharma that target microvascular health in order to prevent cognitive and cardiac disease progression, reduce morbidity and ultimately improve quality of life for patients.

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The information about "CRUCIAL" are provided by the European Opendata Portal: CORDIS opendata.

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