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TO_AITION SIGNED

A high-dimensional approach for unwinding immune-metabolic causes of cardiovascular disease-depression multimorbidities

Total Cost €

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EC-Contrib. €

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Partnership

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Project "TO_AITION" data sheet

The following table provides information about the project.

Coordinator
IDRYMA IATROVIOLOGIKON EREUNON AKADEMIAS ATHINON 

Organization address
address: SORANOU EFESIOU 4
city: ATHINA
postcode: 115 27
website: www.bioacademy.gr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Greece [EL]
 Total cost 5˙990˙515 €
 EC max contribution 5˙990˙515 € (100%)
 Programme 1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease)
 Code Call H2020-SC1-2019-Two-Stage-RTD
 Funding Scheme RIA
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2024-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    IDRYMA IATROVIOLOGIKON EREUNON AKADEMIAS ATHINON EL (ATHINA) coordinator 879˙343.00
2    PANEPISTIMIO IOANNINON EL (IOANNINA) participant 661˙000.00
3    PIRKANMAA HOSPITAL DISTRICT FI (TAMPERE) participant 526˙400.00
4    UNIVERSITE DE GENEVE CH (GENEVE) participant 483˙750.00
5    UNIVERSITAIR MEDISCH CENTRUM UTRECHT NL (UTRECHT) participant 473˙750.00
6    UNIVERSITEIT VAN AMSTERDAM NL (AMSTERDAM) participant 458˙155.00
7    UNIVERSITATSKLINIKUM BONN DE (BONN) participant 440˙000.00
8    STICHTING VUMC NL (AMSTERDAM) participant 429˙682.00
9    MICRONIT MICROTECHNOLOGIES BV NL (ENSCHEDE) participant 351˙775.00
10    RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG DE (HEIDELBERG) participant 330˙000.00
11    UNIVERSYTET MEDYCZNY W LODZI. PL (LODZ) participant 252˙000.00
12    GENOWAY FR (LYON) participant 249˙921.00
13    MARIOS LYMARAKIS KAI SIA EE EL (GERAKAS ATTIKI) participant 249˙812.00
14    SOCIETE EUROPEENNE DE CARDIOLOGIE FR (BIOT SOPHIA ANTIPOLIS) participant 204˙925.00

Map

 Project objective

Depression is a common and serious comorbidity of cardiovascular disease (CVD) affecting one in three patients, among which women earlier and more frequently. Depression increases the risk for CVD development, acute events and mortality by >2 fold, independently of traditional risk factors, and constitutes an enormous socioeconomic burden in terms of morbidity, mortality and healthcare costs. Still, the patients at risk, disease trajectories and causative mechanisms involved remain unknown. TO_AITION addresses the hypothesis that immune-metabolic dysregulation, occurring as a result of genetic, lifestyle and environmental risk factors ‘training’ innate immunity, drives low grade systemic inflammation leading to the development of CVD-depression comorbidity. It integrates basic (cell models, immune-metabolic mechanisms, myeloid cell reprogramming), preclinical (animal models, CRISPR genome editing) and clinical (longitudinal cohorts with comprehensive existing data) research, in order to characterise immune-metabolic mechanisms driving CVD-depression comorbidity. Both hypothesis and data-driven strategies will be employed to address causality, focusing on genetic, epigenetic, transcriptional, metabolic and other disturbances leading to the development of comorbidity. Drug-drug interactions and their effects on causative mechanisms and disease trajectories will also be determined. Pathways identified will be evaluated in cell-based and animal models to prove their causal role and obtain mechanistic insight. Finally, new risk models will be developed, and relevant regulatory, cost-effectiveness and feasibility issues addressed. Effective patient-oriented awareness actions, dissemination, exploitation and management activities are also provisioned. TO_AITION will therefore rationally change our current understanding of the causative mechanisms driving CVD-depression comorbidity, unravelling patients’ complexity and improving their diagnosis, monitoring and management.

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