Explore the words cloud of the TO_AITION project. It provides you a very rough idea of what is the project "TO_AITION" about.
The following table provides information about the project.
IDRYMA IATROVIOLOGIKON EREUNON AKADEMIAS ATHINON
|Coordinator Country||Greece [EL]|
|Total cost||5˙990˙515 €|
|EC max contribution||5˙990˙515 € (100%)|
1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease)
|Duration (year-month-day)||from 2020-01-01 to 2024-12-31|
Take a look of project's partnership.
|1||IDRYMA IATROVIOLOGIKON EREUNON AKADEMIAS ATHINON||EL (ATHINA)||coordinator||879˙343.00|
|2||PANEPISTIMIO IOANNINON||EL (IOANNINA)||participant||661˙000.00|
|3||PIRKANMAA HOSPITAL DISTRICT||FI (TAMPERE)||participant||526˙400.00|
|4||UNIVERSITE DE GENEVE||CH (GENEVE)||participant||483˙750.00|
|5||UNIVERSITAIR MEDISCH CENTRUM UTRECHT||NL (UTRECHT)||participant||473˙750.00|
|6||UNIVERSITEIT VAN AMSTERDAM||NL (AMSTERDAM)||participant||458˙155.00|
|7||UNIVERSITATSKLINIKUM BONN||DE (BONN)||participant||440˙000.00|
|8||STICHTING VUMC||NL (AMSTERDAM)||participant||429˙682.00|
|9||MICRONIT MICROTECHNOLOGIES BV||NL (ENSCHEDE)||participant||351˙775.00|
|10||RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG||DE (HEIDELBERG)||participant||330˙000.00|
|11||UNIVERSYTET MEDYCZNY W LODZI.||PL (LODZ)||participant||252˙000.00|
|13||MARIOS LYMARAKIS KAI SIA EE||EL (GERAKAS ATTIKI)||participant||249˙812.00|
|14||SOCIETE EUROPEENNE DE CARDIOLOGIE||FR (BIOT SOPHIA ANTIPOLIS)||participant||204˙925.00|
Depression is a common and serious comorbidity of cardiovascular disease (CVD) affecting one in three patients, among which women earlier and more frequently. Depression increases the risk for CVD development, acute events and mortality by >2 fold, independently of traditional risk factors, and constitutes an enormous socioeconomic burden in terms of morbidity, mortality and healthcare costs. Still, the patients at risk, disease trajectories and causative mechanisms involved remain unknown. TO_AITION addresses the hypothesis that immune-metabolic dysregulation, occurring as a result of genetic, lifestyle and environmental risk factors ‘training’ innate immunity, drives low grade systemic inflammation leading to the development of CVD-depression comorbidity. It integrates basic (cell models, immune-metabolic mechanisms, myeloid cell reprogramming), preclinical (animal models, CRISPR genome editing) and clinical (longitudinal cohorts with comprehensive existing data) research, in order to characterise immune-metabolic mechanisms driving CVD-depression comorbidity. Both hypothesis and data-driven strategies will be employed to address causality, focusing on genetic, epigenetic, transcriptional, metabolic and other disturbances leading to the development of comorbidity. Drug-drug interactions and their effects on causative mechanisms and disease trajectories will also be determined. Pathways identified will be evaluated in cell-based and animal models to prove their causal role and obtain mechanistic insight. Finally, new risk models will be developed, and relevant regulatory, cost-effectiveness and feasibility issues addressed. Effective patient-oriented awareness actions, dissemination, exploitation and management activities are also provisioned. TO_AITION will therefore rationally change our current understanding of the causative mechanisms driving CVD-depression comorbidity, unravelling patients’ complexity and improving their diagnosis, monitoring and management.
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The information about "TO_AITION" are provided by the European Opendata Portal: CORDIS opendata.