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ExocyTher SIGNED

Extracellular vesicle production and engineering by turbulence for fistula therapy in thermoreversible hydrogels

Total Cost €

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EC-Contrib. €

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Partnership

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 ExocyTher project word cloud

Explore the words cloud of the ExocyTher project. It provides you a very rough idea of what is the project "ExocyTher" about.

morbidity    differentiation    vesicles    capitalizing    tackle    lt    regulatory    authorized    attempt    mitigating    engineering    ascs    people    efficient    surgery    release    stem    trial    cancer    synergic    cells    administration    translation    exocyther    considering    body    burden    regenerative    scs    replication    turbulence    indications    adipose    culture    evs    scalable    health    triggered    hampered    inflammatory    entire    off    extended    gains    gel    storage    disease    crohn    retain    fistula    therapeutic    immunomodulatory    bioreactors    asc    specially    yield    basis    secondary    technological    occlusive    parent    mother    standardized    therapy    uncontrolled    tract    fill    20    vesiculation    effect    ev    life    preliminary    scientific    medicine    label    risks    recapitulate    cell    shelf    companion    vehicle    stress    temperature    fistulas    occlusion    building    rate    gelling    types    first    millions    vascular    injectable    sc    device    site    trauma    medical    shear    deg    priming    induce    foreseeing    clinical    extracellular   

Project "ExocyTher" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙496˙094 €
 EC max contribution 1˙496˙094 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2020
 Duration (year-month-day) from 2020-06-01   to  2025-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 1˙496˙094.00

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 Project objective

Extracellular vesicles (EVs) from stem cells (SCs) may recapitulate the therapeutic effect of their mother cells in regenerative medicine while mitigating risks of uncontrolled replication, differentiation and vascular occlusion, offering “off-the-shelf”, storage and shelf-life gains. Yet, the clinical translation of SC EV therapy is hampered by production, engineering and administration challenges. Building on my preliminary results, ExocyTher aims at developing SC EV therapy through: (1) standardized scalable high-yield EV production: I propose the concept of turbulence vesiculation to induce EV release from adipose SCs (ASCs) by a controlled turbulence shear stress integrated to large-scale cell culture in bioreactors; (2) optimised delivery: I propose EV administration in a synergic fistula-occlusive companion gel (injectable at <20°C and gelling at body temperature) in the attempt to fill the entire fistula tract and retain EVs at the site of interest; ExocyTher will tackle the therapy of fistulas, a major health burden related to Crohn's disease or secondary to surgery, cancer therapy or trauma, affecting millions of people in Europe with a high morbidity rate. All-in-one turbulence-triggered vesiculation and priming are expected to provide ASC EVs in high yield and with improved immunomodulatory properties specially for a more efficient therapy of inflammatory Crohn’s disease fistulas. Capitalizing on the use of a gel medical device authorized in Europe as an off-label fistula occlusive EV vehicle and considering key regulatory issues, ExocyTher will set the basis for the first clinical trial on ASC EV fistula therapy. ExocyTher concepts may be extended to other EV parent cell types or therapy indications, foreseeing a high scientific and technological impact.

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The information about "EXOCYTHER" are provided by the European Opendata Portal: CORDIS opendata.

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