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ExocyTher SIGNED

Extracellular vesicle production and engineering by turbulence for fistula therapy in thermoreversible hydrogels

Total Cost €

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EC-Contrib. €

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Partnership

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 ExocyTher project word cloud

Explore the words cloud of the ExocyTher project. It provides you a very rough idea of what is the project "ExocyTher" about.

fill    asc    parent    immunomodulatory    surgery    extended    crohn    synergic    release    label    hampered    scalable    tract    life    ascs    turbulence    gelling    entire    preliminary    fistulas    injectable    attempt    types    vascular    gel    companion    tackle    regenerative    people    morbidity    standardized    vehicle    medicine    health    triggered    recapitulate    rate    trial    exocyther    occlusion    extracellular    gains    mother    vesicles    secondary    scs    temperature    off    mitigating    risks    cancer    sc    shelf    disease    first    technological    scientific    efficient    regulatory    priming    bioreactors    trauma    specially    basis    ev    millions    building    cell    device    therapeutic    lt    inflammatory    vesiculation    engineering    evs    therapy    retain    20    fistula    considering    body    site    effect    differentiation    adipose    indications    culture    stress    foreseeing    storage    translation    clinical    yield    administration    induce    medical    shear    occlusive    burden    stem    capitalizing    deg    cells    authorized    replication    uncontrolled   

Project "ExocyTher" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙496˙094 €
 EC max contribution 1˙496˙094 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2020
 Duration (year-month-day) from 2020-06-01   to  2025-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 1˙496˙094.00

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 Project objective

Extracellular vesicles (EVs) from stem cells (SCs) may recapitulate the therapeutic effect of their mother cells in regenerative medicine while mitigating risks of uncontrolled replication, differentiation and vascular occlusion, offering “off-the-shelf”, storage and shelf-life gains. Yet, the clinical translation of SC EV therapy is hampered by production, engineering and administration challenges. Building on my preliminary results, ExocyTher aims at developing SC EV therapy through: (1) standardized scalable high-yield EV production: I propose the concept of turbulence vesiculation to induce EV release from adipose SCs (ASCs) by a controlled turbulence shear stress integrated to large-scale cell culture in bioreactors; (2) optimised delivery: I propose EV administration in a synergic fistula-occlusive companion gel (injectable at <20°C and gelling at body temperature) in the attempt to fill the entire fistula tract and retain EVs at the site of interest; ExocyTher will tackle the therapy of fistulas, a major health burden related to Crohn's disease or secondary to surgery, cancer therapy or trauma, affecting millions of people in Europe with a high morbidity rate. All-in-one turbulence-triggered vesiculation and priming are expected to provide ASC EVs in high yield and with improved immunomodulatory properties specially for a more efficient therapy of inflammatory Crohn’s disease fistulas. Capitalizing on the use of a gel medical device authorized in Europe as an off-label fistula occlusive EV vehicle and considering key regulatory issues, ExocyTher will set the basis for the first clinical trial on ASC EV fistula therapy. ExocyTher concepts may be extended to other EV parent cell types or therapy indications, foreseeing a high scientific and technological impact.

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