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READY SIGNED

Getting ready to treat human patients with nanobody-targeted photodynamic therapy

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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0

 READY project word cloud

Explore the words cloud of the READY project. It provides you a very rough idea of what is the project "READY" about.

commercialisation    distribute    capacity    competitor    ready    poc    version    prolongs    accurately    viability    tumor    antibody    explore    vivo    ascertain    homogenously    lack    trigger    dr    oliveira    activation    tissue    efficacy    benefit    patients    operate    nanobody    treatment    fragments    perform    stakeholder    ip    induce    healthy    damaging    photosensitizer    photosensitizers    ideally    commercial    team    light    limits    therapeutic    photosensitivity    uses    regression    erc    gmp    specificity    indicate    cure    severe    landscape    extensive    translation    execute    guide    unbound    nanobodies    fundamental    alternative    market    fto    neck    immune    therapy    eliminated    killcancer    humans    head    small    cancer    eradicate    photodynamic    therapies    local    humanize    protection    locally    plan    fail    mechanism    pdt    stg    cells    freedom    conventional    bind    business    validate    society    unfortunately    selectivity   

Project "READY" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITEIT UTRECHT 

Organization address
address: HEIDELBERGLAAN 8
city: UTRECHT
postcode: 3584 CS
website: www.uu.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 0 €
 EC max contribution 150˙000 € (0%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-PoC
 Funding Scheme ERC-POC-LS
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2021-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITEIT UTRECHT NL (UTRECHT) coordinator 150˙000.00

Map

 Project objective

Unfortunately, current cancer therapies often fail to cure patients, or are associated with severe side effects. Ideally, a therapy should locally eradicate cancer cells without damaging healthy tissue and should induce long term protection through activation of the immune system. Photodynamic therapy (PDT) is a treatment approach which can do both, through the local light activation of photosensitizers. However, current photosensitizers lack cancer specificity, which limits therapeutic efficacy and prolongs photosensitivity in patients. Recently, Dr. Oliveira has developed an improved version of targeted PDT that uses small antibody fragments, i.e. nanobodies, to target the photosensitizer to cancer cells. Nanobodies distribute homogenously, bind rapidly and specifically to cancer cells, and are quickly eliminated when unbound. Within the ERC StG KILLCANCER project, the team has been focusing on better understanding the mechanism of nanobody-targeted PDT, its potential to induce tumor regression in vivo, and its capacity to trigger the immune system for long term protection. Results indicate this treatment could lead to improved selectivity and reduced side effects, compared to conventional PDT and antibody-targeted PDT. The fundamental objective of this ERC PoC is to ascertain the technical and commercial viability of nanobody-targeted PDT for treatment of head and neck cancer. Within this project, the aims are to: 1. Humanize the lead nanobody, validate the results, and explore GMP production 2. Perform an IP landscape analysis and establish freedom-to-operate (FTO) 3. Execute an extensive market, competitor, and stakeholder analysis, and 4. Develop a detailed business plan based on this information to accurately guide commercialisation. Together, these steps will be essential for nanobody-targeted PDT to be ready for the translation to humans, so that cancer patients and society as a whole can benefit from this promising alternative treatment.

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The information about "READY" are provided by the European Opendata Portal: CORDIS opendata.

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