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READY SIGNED

Getting ready to treat human patients with nanobody-targeted photodynamic therapy

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 READY project word cloud

Explore the words cloud of the READY project. It provides you a very rough idea of what is the project "READY" about.

treatment    bind    capacity    limits    immune    unbound    nanobodies    local    society    ascertain    tumor    humanize    perform    mechanism    operate    patients    cancer    commercialisation    vivo    commercial    regression    accurately    dr    ideally    tissue    unfortunately    extensive    oliveira    humans    efficacy    killcancer    explore    ready    cure    version    pdt    fail    alternative    execute    plan    gmp    neck    indicate    photosensitizers    validate    prolongs    light    fundamental    therapeutic    translation    landscape    conventional    damaging    activation    small    business    lack    specificity    healthy    freedom    erc    eliminated    poc    locally    benefit    uses    severe    induce    selectivity    fto    eradicate    therapy    viability    photodynamic    nanobody    cells    guide    stg    competitor    ip    market    team    fragments    antibody    trigger    photosensitizer    homogenously    distribute    therapies    head    protection    stakeholder    photosensitivity   

Project "READY" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITEIT UTRECHT 

Organization address
address: HEIDELBERGLAAN 8
city: UTRECHT
postcode: 3584 CS
website: www.uu.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 0 €
 EC max contribution 150˙000 € (0%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-PoC
 Funding Scheme ERC-POC-LS
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2021-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITEIT UTRECHT NL (UTRECHT) coordinator 150˙000.00

Map

 Project objective

Unfortunately, current cancer therapies often fail to cure patients, or are associated with severe side effects. Ideally, a therapy should locally eradicate cancer cells without damaging healthy tissue and should induce long term protection through activation of the immune system. Photodynamic therapy (PDT) is a treatment approach which can do both, through the local light activation of photosensitizers. However, current photosensitizers lack cancer specificity, which limits therapeutic efficacy and prolongs photosensitivity in patients. Recently, Dr. Oliveira has developed an improved version of targeted PDT that uses small antibody fragments, i.e. nanobodies, to target the photosensitizer to cancer cells. Nanobodies distribute homogenously, bind rapidly and specifically to cancer cells, and are quickly eliminated when unbound. Within the ERC StG KILLCANCER project, the team has been focusing on better understanding the mechanism of nanobody-targeted PDT, its potential to induce tumor regression in vivo, and its capacity to trigger the immune system for long term protection. Results indicate this treatment could lead to improved selectivity and reduced side effects, compared to conventional PDT and antibody-targeted PDT. The fundamental objective of this ERC PoC is to ascertain the technical and commercial viability of nanobody-targeted PDT for treatment of head and neck cancer. Within this project, the aims are to: 1. Humanize the lead nanobody, validate the results, and explore GMP production 2. Perform an IP landscape analysis and establish freedom-to-operate (FTO) 3. Execute an extensive market, competitor, and stakeholder analysis, and 4. Develop a detailed business plan based on this information to accurately guide commercialisation. Together, these steps will be essential for nanobody-targeted PDT to be ready for the translation to humans, so that cancer patients and society as a whole can benefit from this promising alternative treatment.

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The information about "READY" are provided by the European Opendata Portal: CORDIS opendata.

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