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READY SIGNED

Getting ready to treat human patients with nanobody-targeted photodynamic therapy

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 READY project word cloud

Explore the words cloud of the READY project. It provides you a very rough idea of what is the project "READY" about.

explore    tumor    ascertain    execute    translation    efficacy    homogenously    mechanism    induce    uses    limits    freedom    lack    commercialisation    ready    guide    competitor    ideally    landscape    patients    therapy    alternative    benefit    antibody    extensive    operate    small    business    nanobodies    stakeholder    ip    conventional    treatment    eliminated    unfortunately    fail    severe    version    poc    nanobody    gmp    humans    activation    light    team    immune    fundamental    erc    validate    healthy    society    tissue    protection    bind    accurately    cancer    commercial    regression    neck    unbound    eradicate    selectivity    plan    photosensitizers    photodynamic    capacity    head    humanize    prolongs    pdt    damaging    local    trigger    cells    oliveira    therapeutic    killcancer    fragments    stg    market    photosensitivity    therapies    dr    photosensitizer    distribute    locally    vivo    viability    cure    indicate    specificity    fto    perform   

Project "READY" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITEIT UTRECHT 

Organization address
address: HEIDELBERGLAAN 8
city: UTRECHT
postcode: 3584 CS
website: www.uu.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 0 €
 EC max contribution 150˙000 € (0%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-PoC
 Funding Scheme ERC-POC-LS
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2021-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITEIT UTRECHT NL (UTRECHT) coordinator 150˙000.00

Map

 Project objective

Unfortunately, current cancer therapies often fail to cure patients, or are associated with severe side effects. Ideally, a therapy should locally eradicate cancer cells without damaging healthy tissue and should induce long term protection through activation of the immune system. Photodynamic therapy (PDT) is a treatment approach which can do both, through the local light activation of photosensitizers. However, current photosensitizers lack cancer specificity, which limits therapeutic efficacy and prolongs photosensitivity in patients. Recently, Dr. Oliveira has developed an improved version of targeted PDT that uses small antibody fragments, i.e. nanobodies, to target the photosensitizer to cancer cells. Nanobodies distribute homogenously, bind rapidly and specifically to cancer cells, and are quickly eliminated when unbound. Within the ERC StG KILLCANCER project, the team has been focusing on better understanding the mechanism of nanobody-targeted PDT, its potential to induce tumor regression in vivo, and its capacity to trigger the immune system for long term protection. Results indicate this treatment could lead to improved selectivity and reduced side effects, compared to conventional PDT and antibody-targeted PDT. The fundamental objective of this ERC PoC is to ascertain the technical and commercial viability of nanobody-targeted PDT for treatment of head and neck cancer. Within this project, the aims are to: 1. Humanize the lead nanobody, validate the results, and explore GMP production 2. Perform an IP landscape analysis and establish freedom-to-operate (FTO) 3. Execute an extensive market, competitor, and stakeholder analysis, and 4. Develop a detailed business plan based on this information to accurately guide commercialisation. Together, these steps will be essential for nanobody-targeted PDT to be ready for the translation to humans, so that cancer patients and society as a whole can benefit from this promising alternative treatment.

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The information about "READY" are provided by the European Opendata Portal: CORDIS opendata.

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