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READY SIGNED

Getting ready to treat human patients with nanobody-targeted photodynamic therapy

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 READY project word cloud

Explore the words cloud of the READY project. It provides you a very rough idea of what is the project "READY" about.

perform    bind    landscape    locally    indicate    gmp    head    competitor    photosensitivity    explore    therapies    killcancer    erc    tissue    limits    patients    prolongs    treatment    stg    humanize    humans    fto    commercialisation    mechanism    local    nanobodies    accurately    operate    eliminated    validate    antibody    fail    lack    freedom    uses    induce    poc    version    eradicate    guide    efficacy    photosensitizer    immune    regression    cells    unfortunately    distribute    cure    nanobody    tumor    cancer    oliveira    extensive    homogenously    photodynamic    dr    society    damaging    fundamental    market    trigger    pdt    execute    photosensitizers    protection    ready    ip    severe    benefit    capacity    neck    specificity    therapeutic    activation    viability    selectivity    commercial    light    vivo    business    stakeholder    ideally    ascertain    team    fragments    small    healthy    translation    conventional    alternative    therapy    plan    unbound   

Project "READY" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITEIT UTRECHT 

Organization address
address: HEIDELBERGLAAN 8
city: UTRECHT
postcode: 3584 CS
website: www.uu.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 0 €
 EC max contribution 150˙000 € (0%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-PoC
 Funding Scheme ERC-POC-LS
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2021-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITEIT UTRECHT NL (UTRECHT) coordinator 150˙000.00

Map

 Project objective

Unfortunately, current cancer therapies often fail to cure patients, or are associated with severe side effects. Ideally, a therapy should locally eradicate cancer cells without damaging healthy tissue and should induce long term protection through activation of the immune system. Photodynamic therapy (PDT) is a treatment approach which can do both, through the local light activation of photosensitizers. However, current photosensitizers lack cancer specificity, which limits therapeutic efficacy and prolongs photosensitivity in patients. Recently, Dr. Oliveira has developed an improved version of targeted PDT that uses small antibody fragments, i.e. nanobodies, to target the photosensitizer to cancer cells. Nanobodies distribute homogenously, bind rapidly and specifically to cancer cells, and are quickly eliminated when unbound. Within the ERC StG KILLCANCER project, the team has been focusing on better understanding the mechanism of nanobody-targeted PDT, its potential to induce tumor regression in vivo, and its capacity to trigger the immune system for long term protection. Results indicate this treatment could lead to improved selectivity and reduced side effects, compared to conventional PDT and antibody-targeted PDT. The fundamental objective of this ERC PoC is to ascertain the technical and commercial viability of nanobody-targeted PDT for treatment of head and neck cancer. Within this project, the aims are to: 1. Humanize the lead nanobody, validate the results, and explore GMP production 2. Perform an IP landscape analysis and establish freedom-to-operate (FTO) 3. Execute an extensive market, competitor, and stakeholder analysis, and 4. Develop a detailed business plan based on this information to accurately guide commercialisation. Together, these steps will be essential for nanobody-targeted PDT to be ready for the translation to humans, so that cancer patients and society as a whole can benefit from this promising alternative treatment.

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Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "READY" are provided by the European Opendata Portal: CORDIS opendata.

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