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INDIGO SIGNED

Effective and Affordable Flu Vaccines for the World

Total Cost €

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EC-Contrib. €

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Partnership

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Project "INDIGO" data sheet

The following table provides information about the project.

Coordinator
ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM 

Organization address
address: MEIBERGDREEF 15
city: AMSTERDAM
postcode: 1105AZ
website: www.amc.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 16˙000˙968 €
 EC max contribution 9˙975˙979 € (62%)
 Programme 1. H2020-EU.3.1.2. (Preventing disease)
 Code Call H2020-SC1-2019-Single-Stage-RTD
 Funding Scheme RIA
 Starting year 2020
 Duration (year-month-day) from 2020-04-01   to  2025-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM NL (AMSTERDAM) coordinator 1˙459˙697.00
2    Universitair Ziekenhuis Gent BE (Gent) participant 1˙779˙591.00
3    LITEVAX BV NL (OPHEMERT) participant 1˙058˙653.00
4    CELLVAX FR (MAISONS-ALFORT) participant 990˙442.00
5    VIROCLINICS BIOSCIENCES BV NL (ROTTERDAM) participant 944˙990.00
6    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) participant 943˙281.00
7    EPIVAX INC US (PROVIDENCE) participant 806˙042.00
8    STANIPHARM FR (CHAMPIGNEULLES) participant 740˙250.00
9    UNIVERSITEIT GENT BE (GENT) participant 642˙692.00
10    EXPRES2ION BIOTECHNOLOGIES APS DK (HORSHOLM) participant 610˙337.00
11    CBCI Society for Medical Education IN (Bangalore) participant 0.00
12    CHRISTIAN MEDICAL COLLEGE VELLORE IN (VELLORE) participant 0.00
13    CLINICAL DEVELOPMENT SERVICES AGENCY IN (FARIDABAD) participant 0.00
14    COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH IN (NEW DEHLI) participant 0.00
15    GENNOVA BIOPHARMACEUTICALS LIMITED IN (PUNE) participant 0.00
16    TRANSLATIONAL HEALTH SCIENCE AND TECHNOLOGY INSTITUTE IN (FARIDABAD) participant 0.00

Map

 Project objective

Despite the availability of flu vaccines for decades, influenza is still an important disease in both developing and developed countries with 500,000 casualties annually and many more people affected. From a global health perspective, the lack of effectivity, availability, affordability and accessibility of flu vaccines significantly limits our ability to respond to the seasonal flu every year and in the event of a pandemic. Currently, a low vaccine effectivity of 40% implies that 60% of vaccinated people are not sufficiently protected, with low confidence further contributing to limited uptake/immunization. In this project, public and private R&D organizations in India, EU and US collaborate on the development of two novel influenza vaccine concepts that meet the requirements of global vaccination, aiming to achieve <10% instead of 60% non-responders, lower costs, and better accessibility. The first approach combines a low dose of a commercial, inactivated, seasonal flu vaccine with a novel, potent adjuvant, and will deliver proof-of-concept in Phase I and IIa trials within 5 years. The second approach builds on three innovations: 1) a novel recombinant HA with increased immunogenicity, 2) a potent adjuvant, and 3) an easy, needle-free delivery by intradermal patches. Contra-productive parts of HA will be removed to increase the immunogenicity of neutralizing epitopes. The adjuvant further stimulates protective immunity and immunological memory. The use of intradermal patches opens possibilities for self-administration, which will improve vaccine uptake in developing as well as developed countries. With proven nonclinical immunogenicity and safety, we will embark on clinical development of this concept after completion of the project. These plans differ in complexity and timelines but are realistic with chances to deliver next-generation flu vaccines for the globe.

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The information about "INDIGO" are provided by the European Opendata Portal: CORDIS opendata.

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