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INDIGO SIGNED

Effective and Affordable Flu Vaccines for the World

Total Cost €

EC-Contrib. €

Partnership

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INDIGO project word cloud

Explore the words cloud of the INDIGO project. It provides you a very rough idea of what is the project "INDIGO" about.

clinical contra epitopes productive immunization vaccine responders global generation confidence meet collaborate decades proof implies stimulates flu plans influenza lack disease globe commercial builds parts countries 40 effectivity vaccines complexity 60 people accessibility dose immunity patches removed immunogenicity intradermal seasonal vaccination immunological iia limited adjuvant self potent nonclinical lower opens sufficiently perspective lt completion 10 proven recombinant pandemic combines protective memory inactivated first realistic chances annually significantly despite affordability timelines limits protected health administration public india neutralizing 500 vaccinated possibilities safety casualties embark instead trials event free innovations private differ needle

Project "INDIGO" data sheet

The following table provides information about the project.

Coordinator	ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM Organization address address: MEIBERGDREEF 15 city: AMSTERDAM postcode: 1105AZ website: www.amc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Netherlands [NL]
Total cost	16˙000˙968 €
EC max contribution	9˙975˙979 € (62%)
Programme	1. H2020-EU.3.1.2. (Preventing disease)
Code Call	H2020-SC1-2019-Single-Stage-RTD
Funding Scheme	RIA
Starting year	2020
Duration (year-month-day)	from 2020-04-01 to 2025-03-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM Organization address address: MEIBERGDREEF 15 city: AMSTERDAM postcode: 1105AZ website: www.amc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (AMSTERDAM)	coordinator	1˙459˙697.00
2	Universitair Ziekenhuis Gent Universitair Ziekenhuis Gent Organization address address: De Pintelaan 185 city: Gent postcode: 9000 website: http://www.uzgent.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (Gent)	participant	1˙779˙591.00
3	LITEVAX BV LITEVAX BV Organization address address: AKKERSESTRAAT 50 city: OPHEMERT postcode: 4061BJ website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (OPHEMERT)	participant	1˙058˙653.00
4	CELLVAX CELLVAX Organization address address: 19 AVENUE DU PROFESSEUR CADIOT city: MAISONS-ALFORT postcode: 94700 website: www.cellvax-pharma.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (MAISONS-ALFORT)	participant	990˙442.00
5	VIROCLINICS BIOSCIENCES BV VIROCLINICS BIOSCIENCES BV Organization address address: MARCONISTRAAT 16 city: ROTTERDAM postcode: 3029 AK website: www.viroclinics.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (ROTTERDAM)	participant	944˙990.00
6	INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE Organization address address: RUE DE TOLBIAC 101 city: PARIS postcode: 75654 website: www.inserm.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	943˙281.00
7	EPIVAX INC EPIVAX INC Organization address address: 188 VALLEY ST SUITE 424 city: PROVIDENCE postcode: 02909 2468 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (PROVIDENCE)	participant	806˙042.00
8	STANIPHARM STANIPHARM Organization address address: RUE JAQUES MONOD 5 city: CHAMPIGNEULLES postcode: 542500 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (CHAMPIGNEULLES)	participant	740˙250.00
9	UNIVERSITEIT GENT UNIVERSITEIT GENT Organization address address: SINT PIETERSNIEUWSTRAAT 25 city: GENT postcode: 9000 website: http://www.ugent.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (GENT)	participant	642˙692.00
10	EXPRES2ION BIOTECHNOLOGIES APS EXPRES2ION BIOTECHNOLOGIES APS Organization address address: AGERN ALLE 1 city: HORSHOLM postcode: 2970 website: www.expres2ionbio.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (HORSHOLM)	participant	610˙337.00
11	CBCI Society for Medical Education CBCI Society for Medical Education Organization address address: St. John's National Academy of Health Sciences city: Bangalore postcode: 560034 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IN (Bangalore)	participant	0.00
12	CHRISTIAN MEDICAL COLLEGE VELLORE CHRISTIAN MEDICAL COLLEGE VELLORE Organization address address: THORAPADI BAGAYAM city: VELLORE postcode: 632002 website: www.cmch-vellore.edu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IN (VELLORE)	participant	0.00
13	CLINICAL DEVELOPMENT SERVICES AGENCY CLINICAL DEVELOPMENT SERVICES AGENCY Organization address address: THSTI BUILDING NCR BIOTECH SCIENCE CLUSTER 3RD MILESTONE GURUGRAM FARIDABAD EXPESSWAY city: FARIDABAD postcode: 121001 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IN (FARIDABAD)	participant	0.00
14	COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH Organization address address: Anusandhan Bhawan, Rafi Marg 2 city: NEW DEHLI postcode: 110001 website: www.csir.res.in contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IN (NEW DEHLI)	participant	0.00
15	GENNOVA BIOPHARMACEUTICALS LIMITED GENNOVA BIOPHARMACEUTICALS LIMITED Organization address address: EMCURE HOUSE T 184 MIDC BHOSARI city: PUNE postcode: 411026 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IN (PUNE)	participant	0.00
16	TRANSLATIONAL HEALTH SCIENCE AND TECHNOLOGY INSTITUTE TRANSLATIONAL HEALTH SCIENCE AND TECHNOLOGY INSTITUTE Organization address address: NCR BIOTECH SCIENCE CLUSTER 3RD MILESTONE HARYANA city: FARIDABAD postcode: 121001 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IN (FARIDABAD)	participant	0.00

Map

Project objective

Despite the availability of flu vaccines for decades, influenza is still an important disease in both developing and developed countries with 500,000 casualties annually and many more people affected. From a global health perspective, the lack of effectivity, availability, affordability and accessibility of flu vaccines significantly limits our ability to respond to the seasonal flu every year and in the event of a pandemic. Currently, a low vaccine effectivity of 40% implies that 60% of vaccinated people are not sufficiently protected, with low confidence further contributing to limited uptake/immunization. In this project, public and private R&D organizations in India, EU and US collaborate on the development of two novel influenza vaccine concepts that meet the requirements of global vaccination, aiming to achieve <10% instead of 60% non-responders, lower costs, and better accessibility. The first approach combines a low dose of a commercial, inactivated, seasonal flu vaccine with a novel, potent adjuvant, and will deliver proof-of-concept in Phase I and IIa trials within 5 years. The second approach builds on three innovations: 1) a novel recombinant HA with increased immunogenicity, 2) a potent adjuvant, and 3) an easy, needle-free delivery by intradermal patches. Contra-productive parts of HA will be removed to increase the immunogenicity of neutralizing epitopes. The adjuvant further stimulates protective immunity and immunological memory. The use of intradermal patches opens possibilities for self-administration, which will improve vaccine uptake in developing as well as developed countries. With proven nonclinical immunogenicity and safety, we will embark on clinical development of this concept after completion of the project. These plans differ in complexity and timelines but are realistic with chances to deliver next-generation flu vaccines for the globe.

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The information about "INDIGO" are provided by the European Opendata Portal: CORDIS opendata.