Opendata, web and dolomites
MATCH SIGNED
Discovering a novel allergen immunotherapy in house dust mite allergy tolerance research
Total Cost €
0EC-Contrib. €
0Partnership
0Views
0MATCH project word cloud
Explore the words cloud of the MATCH project. It provides you a very rough idea of what is the project "MATCH" about.
content
biopharmaceutical
window
actively
function
antigens
molecule
diseases
sialylation
induce
tolerance
immune
significantly
extended
decennia
body
cell
effector
dust
unexpected
medical
scientific
autoimmune
dcs
cancer
opportunity
cells
tumors
clinical
induces
allergies
modification
linker
serendipity
allergy
shorter
erc
last
efficacy
cure
poc
hdm
allergen
mite
validation
match
couple
chronic
allergens
opens
suppress
reached
protocols
tumor
sciences
overwhelming
discovered
display
vaccine
anti
treatment
dendritic
acid
curative
scientists
house
immunotherapy
inflammation
potentiator
sialic
acids
Project "MATCH" data sheet
The following table provides information about the project.
| Coordinator |
STICHTING VUMC
Organization address contact info |
| Coordinator Country | Netherlands [NL] |
| Total cost | 0 € |
| EC max contribution | 150˙000 € (0%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2019-PoC |
| Funding Scheme | ERC-POC-LS |
| Starting year | 2020 |
| Duration (year-month-day) | from 2020-01-01 to 2021-06-30 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | STICHTING VUMC | NL (AMSTERDAM) | coordinator | 150˙000.00 |
Map
Project objective
The advances in medical sciences and biopharmaceutical development during the last decennia have been overwhelming. While the scientific and clinical insight in numerous diseases have significantly increased, the curative treatment to most diseases is still not in reach. The most common diseases such as cancer and chronic diseases are still challenging scientists. Therefore, during our ERC Advanced project the main goal was to develop a vaccine to cure cancer using targeted immunotherapy. We used dendritic cells (DCs) as potentiator to improve anti-tumor T cell activity. However, we discovered that many tumors display a high content of sialic acids which actively suppress DCs function and induce tolerance to tumor associated antigens. This unexpected serendipity finding that sialylation of tumor associated antigens induced tolerance to the body’s immune response opens a window of opportunity to use sialylation (modification with sialic acid) to induce tolerance in allergies, such as house dust mite allergy (HDM). In the ERC PoC project (MATCH) I will couple HDM major allergens to specific sialic acid using a linker molecule to induce immune tolerance towards effector T cells in inflammation processes during HDM allergy. The results will lead to validation of the technology developed during the ERC Advanced project and PoC that sialylation induces tolerance when used with HDM allergens. When PoC is reached, the MATCH technology will represent a new allergen immunotherapy in a vaccine technology for HDM allergy with shorter treatment protocols, better efficacy and reduced side effects can be developed. The future potential of this technology may be extended to other allergies and/or autoimmune diseases.
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The information about "MATCH" are provided by the European Opendata Portal: CORDIS opendata.
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lastchecktime (2024-07-27 1:41:19) correctly updated