Opendata, web and dolomites

NEMABOX SIGNED

Deciphering the cyst nematode parasitic program by uncovering how their virulence is orchestrated

Total Cost €

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EC-Contrib. €

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Partnership

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 NEMABOX project word cloud

Explore the words cloud of the NEMABOX project. It provides you a very rough idea of what is the project "NEMABOX" about.

termed    nematode    fellowship    base    experiences    pests    sustainable    effectors    launch    prohibit    mechanisms    biotechnological    recognize    independent    motif    pair    ventral    basis    dog    nematodes    crop    dorsal    academic    virulence    losses    breadth    horizon2020    reader    cyst    species    vivo    question    completion    80    puzzle    primarily    threaten    area    inject    plant    virulent    fungal    glands    level    solutions    first    group    readers    view    effort    explore    drive    discovery    parasitic    sub    holistic    potato    possibility    regulation    line    regulatory    effector    dna    transcription    parasitism    proteins    hundreds    orchestrated    six    spatio    nematicides    interactions    unified    career    security    corresponding    alone    tangible    genetic    either    molecular    conserved    gland    regulations    food    box    tomato    gained    opens    temporal    complete    jigsaw    pathogens    picture    signatures    successful    coding    times   

Project "NEMABOX" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE 

Organization address
address: TRINITY LANE THE OLD SCHOOLS
city: CAMBRIDGE
postcode: CB2 1TN
website: www.cam.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 212˙933 €
 EC max contribution 212˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-04-01   to  2022-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) coordinator 212˙933.00

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 Project objective

Plant parasitic nematodes represent a significant group of plant pathogens that threaten current and future food security. Among them, the cyst nematodes target some of the most important crop species (tomato, potato) and cause up to 80% losses. European regulations prohibit the future use of many effective nematicides. We must improve our understanding of the virulence of the cyst nematodes to identify new targets for a sustainable biotechnological control of these pests. Here, I will use my experiences gained on plant-fungal interactions to address a major question in plant-nematode interactions: how is plant-parasitism orchestrated at the molecular level? To be virulent, cyst nematodes must inject “effector” proteins into the plant. These effectors are primarily produced in either the nematode’s dorsal or sub-ventral glands. Hundreds of these dorsal gland effectors are unified by a six base-pair non coding DNA motif, termed the “DOG box”. In a recent effort, a transcription factor that can recognize the DOG-box was identified, termed the “DOG box reader”. This discovery is the first tangible insight into the regulation of plant-nematode parasitism and opens the possibility to explore a new area of research. However, I recognize that the DOG box and its corresponding reader are only one part of the jigsaw puzzle. To complete the picture, in depth and breadth, I need to know: How does the DOG box reader work in vivo, and does it work alone? What are the genetic signatures and readers of other glands and at other times? To what extent are regulatory mechanisms conserved between cyst nematode species? I expect that successful completion of this fellowship will launch my independent academic career, drive forward the state-of the-art with a holistic “spatio-temporal” view of how plant-nematode parasitism is orchestrated at the molecular level, and provide a basis to explore sustainable solutions for improved food security, in line with the Horizon2020 programme.

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The information about "NEMABOX" are provided by the European Opendata Portal: CORDIS opendata.

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