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CISBOOM SIGNED

Convergence of Information from Separate Brain Areas to Orchestrate Orienting Movements

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 CISBOOM project word cloud

Explore the words cloud of the CISBOOM project. It provides you a very rough idea of what is the project "CISBOOM" about.

coherent    presynaptic    oriented    cortical    ancient    move    monosynaptically    guide    poised    handling    percept    locate    restricted    binding    recruits    varies    alone    attentional    stimuli    examine    coordinates    multiple    interact    animals    modalities    movement    midbrain    conserved    trigger    execute    induce    employ    sites    evolution    receive    area    locations    environment    photon    neurons    fundamental    filtered    anatomical    afferent    first    engages    positions    representation    label    seem    separate    calcium    viruses    attempt    elicit    potentially    receptive    forms    superior    motor    synaptic    orienting    merged    mice    space    content    converging    perception    segregated    structure    neuronal    question    recipient    rotations    sensory    movements    convey    precise    distinctive    create    probe    subpopulation    bind    objects    subcortical    imaging    trans    record    hypothesis    awake    tuning    inputs    patches    colliculus    head    inside    diversity    animal    unified    combined    reveal    functional    brain   

Project "CISBOOM" data sheet

The following table provides information about the project.

Coordinator
UNITED KINGDOM RESEARCH AND INNOVATION 

Organization address
address: POLARIS HOUSE NORTH STAR AVENUE
city: SWINDON
postcode: SN2 1FL
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 224˙933 €
 EC max contribution 224˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2021
 Duration (year-month-day) from 2021-01-01   to  2022-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNITED KINGDOM RESEARCH AND INNOVATION UK (SWINDON) coordinator 224˙933.00

Map

 Project objective

To interact with our environment, we identify, locate and move towards objects of interest. This recruits multiple brain areas, handling separate aspects. Indeed, perception alone engages several cortical and subcortical areas, processing specific features or sensory modalities. How this information is then merged to create a unified percept is a fundamental question, known as the binding problem. Here, we address this question by studying the superior colliculus, a midbrain area essential for orienting. Inside this structure, a neuronal subpopulation forms segregated patches, which elicit precise head rotations, and receive sensory-, motor- and attentional-related inputs. These anatomical sites seem well poised to bring together information from similar locations or objects, to induce orienting towards them. To test this hypothesis, I will probe how coherent these converging inputs are, in terms of feature tuning and receptive field coordinates. To investigate if inputs convey filtered information, I will assess the functional diversity of afferent neurons in each brain area. I will then examine whether this content varies across recipient patches, to determine whether stimuli at distinctive positions trigger head rotations. To label and record presynaptic partners, I will employ monosynaptically restricted trans-synaptic viruses, combined with two photon calcium imaging in awake mice. This project will reveal how animals create a representation of space in order to execute target-oriented movements. Because the superior colliculus is an ancient and conserved structure, this is potentially evolution’s first attempt to bind coherent processes to guide movement, animal’s main concern.

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The information about "CISBOOM" are provided by the European Opendata Portal: CORDIS opendata.

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