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ALCO2-FUNC SIGNED

A Remote-carboxylation Strategy for Alcohols via a Dual-catalytic System

Total Cost €

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EC-Contrib. €

0

Partnership

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 ALCO2-FUNC project word cloud

Explore the words cloud of the ALCO2-FUNC project. It provides you a very rough idea of what is the project "ALCO2-FUNC" about.

transfer    functionalities    compounds    photoredox    electron    converted    aliphatic    primary    c1    catalysis    feedstocks    molecules    complexity    chemical    remote    attractive    radical    deemed    alcohols    methodology    catalytic    tether    atom    disciplines    silyl    hydrogen    functional    synthetic    displaying    despite    materials    selective    manner    efforts    setting    neighbouring    partake    basis    func    installed    carboxylated    valuable    largely    synthon    starting    mild    biological    temperature    suitable    introduce    popular    walking    group    directed    alco2    direct    room    carboxylation    carbon    regioselective    considering    introduction    natural    cascade    chemists    underdeveloped    alpha    merger    remotely    single    initiating    synergy    reductive    catalyst    pharmaceuticals    chain    divergent    irradiation    molecular    operate    employed    functionalization    sites    utilized    careful    beta    prevalence    precursors    advantages    chemoselective    energy    counterparts    rebound    inexpensive    strategies    construction    sequence    compatibility    bromo    easily    strategy    readily    nickel    stage    regio    dioxide   

Project "ALCO2-FUNC" data sheet

The following table provides information about the project.

Coordinator
FUNDACIO PRIVADA INSTITUT CATALA D'INVESTIGACIO QUIMICA 

Organization address
address: AVENIDA PAISSOS CATALANS 16
city: TARRAGONA
postcode: 43007
website: www.iciq.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 160˙932 €
 EC max contribution 160˙932 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-03-01   to  2022-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACIO PRIVADA INSTITUT CATALA D'INVESTIGACIO QUIMICA ES (TARRAGONA) coordinator 160˙932.00

Map

 Project objective

The ability to introduce functionality into molecules in a regio- and chemoselective selective manner is of primary importance in the construction of high value molecular compounds but still remains a major challenge for synthetic chemists. The utilization of functionalities present in readily available and inexpensive starting materials to direct the introduction of further complexity is an attractive strategy which has become increasingly popular. Despite recent advances, the remote-functionalization of aliphatic alcohols still remains largely underdeveloped. Considering their prevalence in natural products, compounds displaying important biological activities and chemical feedstocks, efforts to address this problem are deemed necessary. ALCO2-FUNC will make use of an easily installed α bromo-silyl tether to direct functionalization at neighbouring sites. The tether will partake in single electron transfer with a suitable nickel catalyst, initiating a directed radical rebound cascade. The merger of (reductive) nickel catalysis with photoredox catalysis will exploit advantages of both disciplines, enabling the development of a divergent strategy by careful control of key catalytic steps. Furthermore, carbon dioxide will be utilized as a C1 synthon to provide a valuable carboxylation strategy. To such end, simple alcohols will be converted to their β-carboxylated counterparts (via regioselective 1,5 hydrogen atom transfer) or remotely-carboxylated (following a nickel chain-walking sequence). Taken together, the synergy between photoredox and nickel catalysis will be employed in ALCO2-FUNC to develop novel synthetic strategies to access high value compounds from simple precursors. The proposed methodology is expected to operate under mild conditions (room temperature, low-energy irradiation) increasing functional group compatibility and setting the basis for the implementation in the late-stage functionalization of advanced pharmaceuticals.

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The information about "ALCO2-FUNC" are provided by the European Opendata Portal: CORDIS opendata.

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