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Chirality via Cross-Coupling: New Asymmetric C-C Bond Formations Driven by Atom and Step Economy

Total Cost €


EC-Contrib. €






 ChiCC project word cloud

Explore the words cloud of the ChiCC project. It provides you a very rough idea of what is the project "ChiCC" about.

organo    molecule    asymmetric    despite    regio    complexity    decreased    palladium    prepare    over    formations    philosophy    desirable    broad    family    bond    catalysis    made    structures    tremendous    effort    building    2d    suited    economy    compounds    exert    erc    predominantly    consequently    alkenes    thereby    decades    usually    economical    reactions    bonds    blocks    modern    planar    mainstays    settings    cross    world    relative    circumvent    waste    small    chiral    coupling    aryl    minimising    urgent    enantiomers    60    pseudo    3d    feedstock    80    combined    couplings    catalysed    suzuki    stereocontrol    stereochemistry    actually    concession    selling    prototype    surprisingly    absolute    holds    marketed    preliminary    reaction    esp    libraries    precursors    enantiospecific    efficient    privileged    drug    halides    discovery    nucleophiles    catalyst    drugs    ideals    enantioselective    pharmaceutical    single    fulfil    multiple    atom    activation    industry    detracting    approximately    time    platforms   

Project "ChiCC" data sheet

The following table provides information about the project.


Organization address
postcode: L69 7ZX

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 1˙999˙890 €
 EC max contribution 1˙999˙890 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-COG
 Funding Scheme ERC-COG
 Starting year 2020
 Duration (year-month-day) from 2020-06-01   to  2025-05-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF LIVERPOOL UK (LIVERPOOL) coordinator 1˙999˙890.00


 Project objective

Over 60% of the world’s top selling small molecule drug compounds are chiral and, of these, approximately 80% are marketed as single enantiomers. Surprisingly, and despite the tremendous advances made in catalysis over the past several decades, the average “chiral complexity” of drug discovery libraries has actually decreased, while, at the same time the “chiral complexity” of marketed drugs has increased. Consequently, there is now an urgent need to provide efficient processes that access directly privileged chiral “3D” building blocks. It is our philosophy that catalysis holds the key here and new processes should be based upon atom and step economical platforms that exert control over both absolute and relative stereochemistry. Palladium catalysed cross-coupling reactions of aryl (pseudo)halides with organo-nucleophiles (esp. the Suzuki coupling) have become mainstays of the pharmaceutical industry. Here, multiple “concession” steps are usually required to prepare the reaction partners, thereby detracting from atom and step economy. Further, these processes predominantly provide planar “2D” structures and are not well suited to the production of chiral “3D” building blocks. Consequently, methods that allow feedstock precursors (e.g. alkenes and aryl C-H bonds) to be combined directly in enantioselective or enantiospecific C-C bond formations are highly desirable. Cross-couplings of this type would circumvent “concession” steps, thereby minimising cost, effort and waste; however, such processes are highly challenging because of issues associated with regio- and stereocontrol. Recently, we developed prototype catalyst systems that can address this. In the proposed ERC project, these exciting preliminary results will be developed into a wider family of processes where asymmetric C-C bond formations are achieved directly by C-H activation. The new methods, which fulfil modern reaction ideals of atom and step economy, will likely find broad use in applied settings.

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The information about "CHICC" are provided by the European Opendata Portal: CORDIS opendata.

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