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ChiCC SIGNED

Chirality via Cross-Coupling: New Asymmetric C-C Bond Formations Driven by Atom and Step Economy

Total Cost €

0

EC-Contrib. €

0

Partnership

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 ChiCC project word cloud

Explore the words cloud of the ChiCC project. It provides you a very rough idea of what is the project "ChiCC" about.

bond    usually    effort    3d    80    economical    catalyst    molecule    economy    surprisingly    planar    urgent    industry    stereochemistry    family    activation    reactions    philosophy    selling    enantiospecific    single    minimising    complexity    coupling    enantioselective    concession    combined    approximately    stereocontrol    relative    broad    esp    over    exert    made    ideals    circumvent    drugs    holds    60    suited    couplings    waste    platforms    discovery    efficient    blocks    actually    tremendous    libraries    preliminary    atom    desirable    2d    organo    prepare    erc    structures    multiple    compounds    marketed    time    suzuki    cross    halides    predominantly    nucleophiles    alkenes    bonds    chiral    catalysed    absolute    pseudo    mainstays    decreased    detracting    decades    formations    reaction    aryl    feedstock    small    drug    pharmaceutical    building    consequently    fulfil    modern    privileged    asymmetric    thereby    catalysis    precursors    prototype    settings    palladium    world    enantiomers    despite    regio   

Project "ChiCC" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF LIVERPOOL 

Organization address
address: BROWNLOW HILL 765 FOUNDATION BUILDING
city: LIVERPOOL
postcode: L69 7ZX
website: www.liverpool.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 1˙999˙890 €
 EC max contribution 1˙999˙890 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-COG
 Funding Scheme ERC-COG
 Starting year 2020
 Duration (year-month-day) from 2020-06-01   to  2025-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF LIVERPOOL UK (LIVERPOOL) coordinator 1˙999˙890.00

Map

 Project objective

Over 60% of the world’s top selling small molecule drug compounds are chiral and, of these, approximately 80% are marketed as single enantiomers. Surprisingly, and despite the tremendous advances made in catalysis over the past several decades, the average “chiral complexity” of drug discovery libraries has actually decreased, while, at the same time the “chiral complexity” of marketed drugs has increased. Consequently, there is now an urgent need to provide efficient processes that access directly privileged chiral “3D” building blocks. It is our philosophy that catalysis holds the key here and new processes should be based upon atom and step economical platforms that exert control over both absolute and relative stereochemistry. Palladium catalysed cross-coupling reactions of aryl (pseudo)halides with organo-nucleophiles (esp. the Suzuki coupling) have become mainstays of the pharmaceutical industry. Here, multiple “concession” steps are usually required to prepare the reaction partners, thereby detracting from atom and step economy. Further, these processes predominantly provide planar “2D” structures and are not well suited to the production of chiral “3D” building blocks. Consequently, methods that allow feedstock precursors (e.g. alkenes and aryl C-H bonds) to be combined directly in enantioselective or enantiospecific C-C bond formations are highly desirable. Cross-couplings of this type would circumvent “concession” steps, thereby minimising cost, effort and waste; however, such processes are highly challenging because of issues associated with regio- and stereocontrol. Recently, we developed prototype catalyst systems that can address this. In the proposed ERC project, these exciting preliminary results will be developed into a wider family of processes where asymmetric C-C bond formations are achieved directly by C-H activation. The new methods, which fulfil modern reaction ideals of atom and step economy, will likely find broad use in applied settings.

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