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MechanoSelfFate SIGNED

Role of Tissue Mechanics in Embryonic Self-Organization and Cell Fate Plasticity

Total Cost €

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EC-Contrib. €

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Partnership

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Project "MechanoSelfFate" data sheet

The following table provides information about the project.

Coordinator
INSTITUT PASTEUR 

Organization address
address: RUE DU DOCTEUR ROUX 25-28
city: PARIS CEDEX 15
postcode: 75724
website: http://www.pasteur.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙995˙334 €
 EC max contribution 1˙995˙334 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-COG
 Funding Scheme ERC-COG
 Starting year 2020
 Duration (year-month-day) from 2020-09-01   to  2025-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT PASTEUR FR (PARIS CEDEX 15) coordinator 1˙995˙334.00

Map

 Project objective

How molecular and mechanical cues interplay to coordinate the morphogenesis and patterning of embryonic structures is an open question in developmental biology. The early avian embryo is an ideal model for the study of such interplay as it exhibits highly regulative development, is greatly amenable to live imaging approaches and can be readily mechanically challenged. Whereas avian embryos have long been known to remarkably adapt and readjust cell fate upon surgical perturbations, such regulative potential has been investigated solely from a molecular standpoint, leaving the role for mechanical forces unexplored. This proposal builds on our recent results and methods characterizing the mechanical control of gastrulation to investigate the role of mechanical forces in embryonic regulation and in cell fate plasticity. Specifically, we propose 1) to develop innovative tools allowing to perturb the mechanical state of early embryos in order characterize the role of forces during development; 2) to test whether a mechanical self-organizing system underlies the remarkable regulative potential avian embryos; 3) to investigate the role of mechanical forces in mesoderm, embryonic and extra-embryonic regional fate allocation. To this end, we will use an interdisciplinary approach combining novel transgenic quail lines, live imaging, and pharmacological/molecular/optogenetic/mechanical perturbations along with theoretical frameworks and modeling approaches. These studies will decipher the interplay between cellular, molecular and mechanical cues that ensures the robust, yet plastic allocation of cell fate in amniote embryos (i.e. reptiles, birds and mammals, including humans).

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The information about "MECHANOSELFFATE" are provided by the European Opendata Portal: CORDIS opendata.

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lastchecktime (2022-08-19 20:49:57) correctly updated