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BESG SIGNED

Bioengineered exosomes based approaches for the effective treatment of non-small cell lung cancer

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 BESG project word cloud

Explore the words cloud of the BESG project. It provides you a very rough idea of what is the project "BESG" about.

dosage    predominant    reduce    medicine    natural    site    composing    patient    biodistribution    alcoholism    acid    occupational    spc24    models    career    smoking    peptide    causes    world    immune    exosomes    release    lung    death    mesenchymal    model    expectancy    smokers    stromal    cell    hsp4    former    gef    bypass    egfr    xenograft    mechanisms    payloads    simultaneously    clinically    origin    nanovesicles    patients    reticuloendothelial    membrane    endogenous    mechanism    payload    bioengineered    cancer    clearance    protein    recognition    sirna    carriers    conjugation    underlying    exo    area    evade    abstract    acids    nanotechnology    technologies    besg    life    precision    principal    drugs    anti    exogenous    sites    era    small    trainings    cells    culture    mscs    engineered    imaging    acceptable    pharmacokinetics    drug    cellular    air    inhibitor    metastasis    pollution    action    res    therapeutics    loading    proteins    exposure    composition    nsclcs    gefitinib    clinical    nucleic    difficult    compliance   

Project "BESG" data sheet

The following table provides information about the project.

Coordinator
PERCUROS BV 

Organization address
address: PLESMANLAAN 1
city: LEIDEN
postcode: 2333 BZ
website: www.percuros.com

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 175˙572 €
 EC max contribution 175˙572 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-SE
 Starting year 2020
 Duration (year-month-day) from 2020-10-01   to  2022-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    PERCUROS BV NL (LEIDEN) coordinator 175˙572.00

Map

 Project objective

ABSTRACT: Lung cancer is the principal cause of cancer-related death around the world and has become more predominant among former than current smokers. Smoking, alcoholism, air pollution, occupational exposure are among the main causes of non-small cell lung cancer (NSCLCs). It is difficult to simultaneously deliver therapeutics and nucleic acid to the target site. With the advancement of nanotechnology, a delivery system composing of cellular proteins which can bypass the reticuloendothelial system (RES) and have the ability to release payload at the specific target site is the necessity of the current era. Exosomes (Exo) are clinically acceptable, having protein membrane composition and the ability to deliver payload at specific target sites. Having endogenous origin, Exo evade immune recognition and clearance compared to exogenous nanovesicles. Exo are natural carriers of nucleic acids and they can be engineered to deliver siRNA as well as anti-cancer drugs. In this we propose the conjugation or covering of mesenchymal stromal cells (MSCs) derived exosomes with HSP4 peptide (target specific to NSCLCs) and loading them with Gefitinib (GEF), an EGFR inhibitor and SPC24 siRNA (target for NSCLCs and metastasis). The delivery of GEF and SPC24 siRNA using bioengineered exosomes (BESG) will reduce their dosage; improve patient compliance and life expectancy of patients. BESG will be evaluated for their uptake mechanisms and their mechanism of action in cell culture models of NSCLCs. BESG will specifically target the NSCLCs and release its payloads at cancer site. The underlying mechanisms, pharmacokinetics, biodistribution and anti-cancer activity will be evaluated in xenograft model of NSCLCs using advance imaging technologies. The BESG developed during this program will have a clinical potential and the trainings obtained through this program will help in career advancement in the area of drug delivery and precision medicine.

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The information about "BESG" are provided by the European Opendata Portal: CORDIS opendata.

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