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LAMININ SIGNED

Light-switchable proteins and Adhesion Micropatterns to Illuminate the Navigation machInery of Neurons

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 LAMININ project word cloud

Explore the words cloud of the LAMININ project. It provides you a very rough idea of what is the project "LAMININ" about.

spatial    machinery    attract    modulate    proteins    directions    reaching    understand    detect    peripheral    chip    attractive    syndrome    wilson    receptors    shown    molecules    cone    attracting    combinations    migration    resolution    extend    optogenetics    don    chemotactant    interactome    cones    trigger    distance    symptoms    proper    cells    structure    multiple    termed    migrate    opposing    embryonic    connect    express    defects    accomplished    micropatterning    guidance    relies    netrin    repel    organ    repulsive    repelling    neurons    correct    nervous    wiring    spectrum    hirschsprung    binds    mowat    intermediate    combinatorial    property    microscopy    receptor    kallmann    switch    neuron    epilepsy    extensions    gradients    normally    central    acc    connectivity    variety    expression    actively    mapping    expressed    aberrant    disease    demonstrated    secreted    aid    neuronal    steering    technologies    complement    directional    helps    unclear    chemotactants    tips    navigation    molecular    disorders    protein    directionality    complexes    neurodevelopmental    autism   

Project "LAMININ" data sheet

The following table provides information about the project.

Coordinator
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM 

Organization address
address: DR MOLEWATERPLEIN 40
city: ROTTERDAM
postcode: 3015 GD
website: www.erasmusmc.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 175˙572 €
 EC max contribution 175˙572 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2020
 Duration (year-month-day) from 2020-04-01   to  2022-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM NL (ROTTERDAM) coordinator 175˙572.00

Map

 Project objective

Proper wiring and connectivity of the central and peripheral nervous system requires that during embryonic development neurons migrate and extend in the correct directions to connect to their targets. Defects in the neuronal navigation machinery lead to a variety of neurodevelopmental disorders such as Hirschsprung’s disease, Kallmann syndrome, ACC and has been associated with autism spectrum disorders and epilepsy. Neuronal navigation relies on a structure at the tips of neuronal extensions, termed the growth cone which is able to detect gradients of guidance molecules (chemotactants) secreted by cells at a distance. The chemotactant netrin, which binds multiple netrin receptors, can switch between attracting and repelling growth cones, a property which helps neurons change directionality upon reaching an intermediate target. While it has been demonstrated that this is related to the complement of netrin receptors expressed by the neuron, it is unclear how different receptor combinations trigger opposing directional responses within the growth cone. It was recently shown that aberrant expression of netrin receptors in cells that don’t normally express it cause aberrant migration of neurons, which might explain some of the symptoms associated with neurodevelopmental disorders such as Mowat-Wilson syndrome. This proposal aims to understand at the molecular level how netrin can both attract and repel neuronal growth cones. This will be accomplished by mapping the interactome of both attractive and repulsive netrin-receptor complexes, and by mapping the spatial distribution and activity of proteins within actively steering growth cones, via high resolution microscopy, micropatterning and optogenetics to spatially modulate protein activities. This combinatorial approach will improve our understanding of neuronal guidance, associated disorders, and new technologies developed in this proposal might aid in the development of novel organ-on-chip technology.

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The information about "LAMININ" are provided by the European Opendata Portal: CORDIS opendata.

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