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LAMININ SIGNED

Light-switchable proteins and Adhesion Micropatterns to Illuminate the Navigation machInery of Neurons

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 LAMININ project word cloud

Explore the words cloud of the LAMININ project. It provides you a very rough idea of what is the project "LAMININ" about.

chip    structure    acc    multiple    disorders    optogenetics    trigger    proper    cells    directional    distance    secreted    reaching    combinations    combinatorial    spectrum    expressed    unclear    shown    embryonic    micropatterning    hirschsprung    epilepsy    normally    guidance    variety    navigation    gradients    opposing    cone    attracting    termed    organ    molecular    accomplished    directions    machinery    repelling    intermediate    don    express    directionality    detect    receptor    property    repel    molecules    neurons    tips    aid    netrin    spatial    extensions    binds    aberrant    complement    receptors    understand    attractive    neurodevelopmental    switch    demonstrated    modulate    correct    syndrome    autism    relies    proteins    actively    migration    disease    mowat    neuron    nervous    connect    steering    chemotactants    expression    peripheral    protein    extend    complexes    helps    repulsive    technologies    interactome    attract    symptoms    neuronal    wiring    microscopy    kallmann    wilson    cones    migrate    mapping    connectivity    defects    central    chemotactant    resolution   

Project "LAMININ" data sheet

The following table provides information about the project.

Coordinator
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM 

Organization address
address: DR MOLEWATERPLEIN 40
city: ROTTERDAM
postcode: 3015 GD
website: www.erasmusmc.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 175˙572 €
 EC max contribution 175˙572 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2020
 Duration (year-month-day) from 2020-04-01   to  2022-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM NL (ROTTERDAM) coordinator 175˙572.00

Map

 Project objective

Proper wiring and connectivity of the central and peripheral nervous system requires that during embryonic development neurons migrate and extend in the correct directions to connect to their targets. Defects in the neuronal navigation machinery lead to a variety of neurodevelopmental disorders such as Hirschsprung’s disease, Kallmann syndrome, ACC and has been associated with autism spectrum disorders and epilepsy. Neuronal navigation relies on a structure at the tips of neuronal extensions, termed the growth cone which is able to detect gradients of guidance molecules (chemotactants) secreted by cells at a distance. The chemotactant netrin, which binds multiple netrin receptors, can switch between attracting and repelling growth cones, a property which helps neurons change directionality upon reaching an intermediate target. While it has been demonstrated that this is related to the complement of netrin receptors expressed by the neuron, it is unclear how different receptor combinations trigger opposing directional responses within the growth cone. It was recently shown that aberrant expression of netrin receptors in cells that don’t normally express it cause aberrant migration of neurons, which might explain some of the symptoms associated with neurodevelopmental disorders such as Mowat-Wilson syndrome. This proposal aims to understand at the molecular level how netrin can both attract and repel neuronal growth cones. This will be accomplished by mapping the interactome of both attractive and repulsive netrin-receptor complexes, and by mapping the spatial distribution and activity of proteins within actively steering growth cones, via high resolution microscopy, micropatterning and optogenetics to spatially modulate protein activities. This combinatorial approach will improve our understanding of neuronal guidance, associated disorders, and new technologies developed in this proposal might aid in the development of novel organ-on-chip technology.

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The information about "LAMININ" are provided by the European Opendata Portal: CORDIS opendata.

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