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Light-switchable proteins and Adhesion Micropatterns to Illuminate the Navigation machInery of Neurons

Total Cost €


EC-Contrib. €






 LAMININ project word cloud

Explore the words cloud of the LAMININ project. It provides you a very rough idea of what is the project "LAMININ" about.

switch    express    receptors    intermediate    neuronal    property    variety    attract    unclear    gradients    understand    modulate    distance    combinations    protein    kallmann    aid    don    aberrant    tips    epilepsy    symptoms    central    secreted    microscopy    molecular    helps    migration    organ    chemotactants    correct    relies    opposing    embryonic    spatial    guidance    cone    cones    acc    detect    extensions    navigation    connectivity    steering    structure    repelling    mapping    resolution    micropatterning    attractive    spectrum    binds    netrin    expression    wilson    accomplished    termed    repel    neurodevelopmental    cells    defects    actively    demonstrated    shown    optogenetics    migrate    combinatorial    connect    molecules    nervous    chip    disease    peripheral    hirschsprung    directional    disorders    neuron    proper    multiple    autism    expressed    normally    complexes    proteins    interactome    attracting    wiring    reaching    syndrome    machinery    receptor    technologies    neurons    mowat    directionality    complement    chemotactant    repulsive    trigger    directions    extend   

Project "LAMININ" data sheet

The following table provides information about the project.


Organization address
postcode: 3015 GD

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 175˙572 €
 EC max contribution 175˙572 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2020
 Duration (year-month-day) from 2020-04-01   to  2022-03-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Proper wiring and connectivity of the central and peripheral nervous system requires that during embryonic development neurons migrate and extend in the correct directions to connect to their targets. Defects in the neuronal navigation machinery lead to a variety of neurodevelopmental disorders such as Hirschsprung’s disease, Kallmann syndrome, ACC and has been associated with autism spectrum disorders and epilepsy. Neuronal navigation relies on a structure at the tips of neuronal extensions, termed the growth cone which is able to detect gradients of guidance molecules (chemotactants) secreted by cells at a distance. The chemotactant netrin, which binds multiple netrin receptors, can switch between attracting and repelling growth cones, a property which helps neurons change directionality upon reaching an intermediate target. While it has been demonstrated that this is related to the complement of netrin receptors expressed by the neuron, it is unclear how different receptor combinations trigger opposing directional responses within the growth cone. It was recently shown that aberrant expression of netrin receptors in cells that don’t normally express it cause aberrant migration of neurons, which might explain some of the symptoms associated with neurodevelopmental disorders such as Mowat-Wilson syndrome. This proposal aims to understand at the molecular level how netrin can both attract and repel neuronal growth cones. This will be accomplished by mapping the interactome of both attractive and repulsive netrin-receptor complexes, and by mapping the spatial distribution and activity of proteins within actively steering growth cones, via high resolution microscopy, micropatterning and optogenetics to spatially modulate protein activities. This combinatorial approach will improve our understanding of neuronal guidance, associated disorders, and new technologies developed in this proposal might aid in the development of novel organ-on-chip technology.

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The information about "LAMININ" are provided by the European Opendata Portal: CORDIS opendata.

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