Opendata, web and dolomites


Advanced Modelling Aided Design of Tissue Engineered Construct for Optimal Soft Tissue Repair

Total Cost €


EC-Contrib. €






Project "MADE-TEC" data sheet

The following table provides information about the project.


Organization address
city: KUOPIO
postcode: 70211

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Finland [FI]
 Total cost 190˙680 €
 EC max contribution 190˙680 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2021
 Duration (year-month-day) from 2021-01-01   to  2022-12-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ITA-SUOMEN YLIOPISTO FI (KUOPIO) coordinator 190˙680.00


 Project objective

Articular cartilage (AC) is a connective tissue that is essential for smooth movement of our joints. Damage to AC leads to a debilitating joint disease called osteoarthritis (OA), which can cause severe restriction of joint movement and overall mobility. Currently, there are more than 40 million Europeans who are affected by OA. Tissue engineering approaches present promising treatment strategy through the replacement of the damaged tissues with tissue-engineered (TE) constructs. Although the current paradigm is to produce a cell-seeded biomaterial that matches the properties of the native tissue, such biomaterial may hinder growth and discourage replacement of the supportive biomaterials by newly synthesized proteins. Current TE constructs integrate poorly with the host tissue, with problems of interfacial gaps and compositional discontinuity, thus impeding their translation to the clinic. As cartilage cells are mechano-sensitive, we hypothesize that the mechanical signals conducive to cell biosynthesis can improve functional integration of TE constructs into host cartilage, and such mechanical signals can be tuned through carefully-designed TE constructs with optimal distribution of material stiffness and cell density. The aim of this research is to develop an advanced computational model that can simulate the biomechanical and growth behaviours of TE constructs and the host cartilage, and to use this model to determine optimal TE construct design that allows for functional integration into the host cartilage. The numerically-determined optimal design will be validated by state-of-the-art bioprinting technology and bioreactor testing. This computational biomechanical growth model will be the first-of-its kind as it can accelerate the design process and improve the performance of the TE constructs. This novel model can make a long-term impact on personalized design of TE constructs and have a high potential to advance the TE technique towards clinical translation.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "MADE-TEC" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email ( and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "MADE-TEC" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

GRAHAM (2018)

Concepts of Graph Theory Applied to the Human Microbiome

Read More  

ENGRAVINg (2019)

Engaging Grammar and Visual Networks

Read More  

DOC-Stim (2020)

Communication and rehabilitation for people with Disorders of consciousness via Brain-Computer Interfaces

Read More