Opendata, web and dolomites

HypoCyclo SIGNED

Multifunctional Polymeric Cyclodextrin Nanocarriers As Novel Triple-Negative Breast Cancer Treatment: A Versatile Photo-Chemotherapy Bypassing Hypoxic Conditions

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 HypoCyclo project word cloud

Explore the words cloud of the HypoCyclo project. It provides you a very rough idea of what is the project "HypoCyclo" about.

bc    situ    cyclolab    thanks    respectively    successful    tissue    drug    presenting    sme    water    lasers    envisage    biocompatible    option    cancers    subtype    load    guaranteeing    therapeutic    aggressive    light    industrial    agent    oxygen    technological    standard    efficacy    complete    training    tnbc    limited    biological    encapsulate    vitro    hypocyclo    combination    nps    fiber    survival    foresees    polymers    solid    profile    completely    loaded    paclitaxel    negative    polymeric    er    give    cells    decoration    upgrade    tailor    keep    insolubility    collaborating    population    generate    mixed    researcher    cancer    decorated    nanoparticles    synthetic    cyclodextrin    ros    multimodal    seeking    agents    supervisor    compromises    ps    cyd    interstitial    synthesis    pdt    tumours    assays    3d    optics    operative    innovative    represented    releasing    release    breast    demanding    ora    options    endowed    tested    female    alternative    2d    poor    species    worldwide    chemotherapy    triple    protocols    20    antitumor    solubilize    therapy    unibo    treatment    photodynamic    optimal    therapies    green    source    covalent    independent    feasible    binding    models    pcx    hypoxia    reactive    polymer    outcome    photosensitizer   

Project "HypoCyclo" data sheet

The following table provides information about the project.

Coordinator
CONSIGLIO NAZIONALE DELLE RICERCHE 

Organization address
address: PIAZZALE ALDO MORO 7
city: ROMA
postcode: 185
website: www.cnr.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 257˙209 €
 EC max contribution 257˙209 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-CAR
 Starting year 2020
 Duration (year-month-day) from 2020-09-01   to  2023-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CONSIGLIO NAZIONALE DELLE RICERCHE IT (ROMA) coordinator 257˙209.00

Map

 Project objective

Among all breast cancers (BC) affecting female population worldwide, 20% is represented by Triple Negative Breast Cancer (TNBC), an aggressive subtype with very limited therapeutic options and poor survival. Seeking for innovative TNBC therapies, HypoCyclo aims at the optimal combination of chemotherapy and photodynamic therapy (PDT). We envisage novel, tailored cyclodextrin (CyD)-based polymeric nanoparticles (NPs) able to load “known” therapeutic agents and decorated with a photosensitizer as well as an Oxygen-Releasing Agent. HypoCyclo focuses on the very effective drug paclitaxel (PCX) presenting several treatment problems like water insolubility. Biocompatible, novel CyD polymers are expected to solubilize and encapsulate through non-covalent binding the drug of choice in order to implement PCX chemotherapy with PDT, through the decoration with a PS able to generate antitumor reactive oxygen species (ROS) in situ. Indeed, PDT has become a very challenging yet feasible option thanks to the technological advances in lasers and fiber-optics allowing interstitial and intra-operative light delivery for the treatment of solid tumours, including BC. Finally, as hypoxia in BC tissue compromises standard chemotherapy and PDT, we will tailor our NPs with an ORA able to release oxygen in cells, enabling an alternative ROS source. The PCX loaded NPs will be completely characterized and tested in 2D and 3D TNBC models. Our goal is to keep the synthetic protocols simple, low-cost and green to facilitate industrial upgrade of the loaded multimodal NPs endowed with improved in vitro efficacy. Two partners, the SME Cyclolab and UNIBO, both already collaborating with the supervisor, will give the necessary support in mixed-CyD polymer synthesis and in the biological assays, respectively, guaranteeing a successful outcome. The project foresees a demanding training program for ER that will help him to become an independent researcher with a complete profile.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "HYPOCYCLO" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "HYPOCYCLO" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

Widow Spider Mating (2020)

Immature mating as a novel tactic of an invasive widow spider

Read More  

SymCO (2020)

Asymptotic Symmetries: from Concepts to Observations

Read More  

GLORIOUS (2019)

Digital Poetry in Today’s Russia: Canonisation and Translation

Read More