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MHT-ImmunoEnhancer SIGNED

Stimuli-Responsive Nanoplatform to Combine Magnetic Hyperthermia with Immunemodulators Delivery for Glioblastoma Treatment

Total Cost €

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EC-Contrib. €

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Partnership

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 MHT-ImmunoEnhancer project word cloud

Explore the words cloud of the MHT-ImmunoEnhancer project. It provides you a very rough idea of what is the project "MHT-ImmunoEnhancer" about.

critical    systemic    superior    therapies    fu    release    depletion    tumour    strategy    oligonucleotide    immune    survival    tme    limit    poor    effect    magnetic    platforms    treatment    inability    regression    immunosupportive    hybrid    damage    polymer    chemotherapeutic    ioncs    enzymes    iron    dual    antitumour    immunosuppressive    enhancement    immunoenhancer    mdscs    tolerance    cells    nanocubes    extremely    limited    conventional    recurrence    glioblastoma    lethal    appropriate    responsive    therapy    efficiency    spreading    gbm    actions    despite    immunotherapy    tumours    cpg    hyperthermal    stimuli    consequently    thermal    untreatable    combine    radiotherapy    retention    appears    stimulus    reactivity    urgent    suppressive    play    agent    establishment    cell    chemotherapy    ed    oxide    human    context    therapeutic    induce    suppressor    fever    surgery    prognosis    ablation    temperature    heating    turn    local    patient    improvements    myeloid    overcome    effectivity    microenvironment    cytotoxic    fluorouracil    mht    site    mdsc    ph    intratumoral    hyperthermia    combination   

Project "MHT-ImmunoEnhancer" data sheet

The following table provides information about the project.

Coordinator
FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA 

Organization address
address: VIA MOREGO 30
city: GENOVA
postcode: 16163
website: www.iit.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 183˙473 €
 EC max contribution 183˙473 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2019
 Duration (year-month-day) from 2019-10-01   to  2021-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA IT (GENOVA) coordinator 183˙473.00

Map

 Project objective

Glioblastoma (GBM) is one of the most lethal and untreatable human tumours, and is characterized by its extremely poor prognosis. Conventional therapies, including surgery, radiotherapy and chemotherapy, have not resulted in major improvements in the survival, due to high recurrence and tumour spreading. Therefore, there is an urgent need to develop new effective therapies to improve patient survival. The establishment of an immunosuppressive tumour microenvironment (TME) in GBM is known to limit the cytotoxic effects of conventional therapies and in this context, myeloid-derived suppressor cells (MDSCs) play a critical role by promoting immune tolerance, tumour growth and spreading. Hyperthermal therapy in GBM has resulted in improved immune reactivity of tumours, despite this, its effectivity has been limited by its inability to overcome the immunosuppressive TME and induce strong systemic antitumour responses. Consequently, targeting MDSCs in combination with thermal ablation therapies appears to be a very promising strategy. The goal of the MHT-ImmunoEnhancer project is the development of a dual stimuli-responsive hybrid polymer/Iron oxide nanocubes (IONCs) delivery system in order to combine local fever-range Magnetic Hyperthermia (MHT) with MDSC depletion-targeted immunotherapy for intratumoral treatment of GBM. The specific objectives of our strategy are, 1) to exploit the superior heating efficiency of the hybrid polymer/IONCs platforms to induce tumour damage. 2) To turn the immunosuppressive TME into an immunosupportive one, by local delivery of CpG oligonucleotide; along with 5-Fluorouracil (5-FU), a chemotherapeutic agent. 3) To release CpG and 5-FU specifically at the tumour site under the appropriate stimulus (pH or enzymes/temperature), thus enhancing their tumour retention and therapeutic effect. All these actions will result in the reduction of T-cell-suppressive activity of MDSCs, enhancement of antitumour immune response and tumour regression.

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