DOS

Drugging the Undruggable: Discovery of Protein-Protein Interaction Modulators Using Diversity-Oriented Synthesis

 Coordinatore THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE 

Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.

 Nazionalità Coordinatore United Kingdom [UK]
 Totale costo 1˙499˙723 €
 EC contributo 1˙499˙723 €
 Programma FP7-IDEAS-ERC
Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call ERC-2011-StG_20101014
 Funding Scheme ERC-SG
 Anno di inizio 2012
 Periodo (anno-mese-giorno) 2012-01-01   -   2016-12-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE

 Organization address address: The Old Schools, Trinity Lane
city: CAMBRIDGE
postcode: CB2 1TN

contact info
Titolo: Dr.
Nome: David
Cognome: Spring
Email: send email
Telefono: +44 1223 336498
Fax: +44 1223 336362

UK (CAMBRIDGE) hostInstitution 1˙499˙723.00
2    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE

 Organization address address: The Old Schools, Trinity Lane
city: CAMBRIDGE
postcode: CB2 1TN

contact info
Titolo: Ms.
Nome: Renata
Cognome: Schaeffer
Email: send email
Telefono: 441223000000
Fax: 441223000000

UK (CAMBRIDGE) hostInstitution 1˙499˙723.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

synthesis    modulation    discovery    biology    oriented    chemical    diversity    protein    enzyme    ppi   

 Obiettivo del progetto (Objective)

'This proposal aims to exploit diversity-oriented synthesis in order to lay the scientific and technological foundations for the development of enzyme inhibition by protein-protein interaction (PPI) modulation as a tool for chemical biology and molecular therapeutics. We will deploy diversity-oriented synthesis lead discovery to explore concepts for PPI modulation in important enzyme families. This work will yield new chemical entities with a spectrum of properties directed against candidate macromolecular interactions important in the regulation of enzymes that mediate key biological pathways. The proposed work has the potential to transform current approaches to drug discovery, and to radically extend the repertoire of tools available for chemical biology. It will help to address the problem of identifying small-molecule inhibitors of PPIs, widely accepted to be of major fundamental and practical significance to biomedical science.'

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