OSTEOGROW

Novel Bone Morphogenetic Protein-6 Biocompatible Carrier Device for Bone Regeneration

Coordinatore	"SVEUCILISTE U ZAGREBU, MEDICINSKI FAKULTET"    more  Organization address address: SALATA 3 city: ZAGREB postcode: 10000 contact info Titolo: Ms. Nome: Smiljka Cognome: Vikic Topic Email: send email Telefono: +385 1 4566972 Fax: +385 1 4566724
Nazionalità Coordinatore	Croatia [HR]
Sito del progetto	http://osteogrow.eu/
Totale costo	7˙384˙746 €
EC contributo	5˙683˙089 €
Programma	FP7-HEALTH Specific Programme "Cooperation": Health
Code Call	FP7-HEALTH-2011-two-stage
Funding Scheme	CP-FP
Anno di inizio	2012
Periodo (anno-mese-giorno)	2012-01-01   -   2016-06-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	"SVEUCILISTE U ZAGREBU, MEDICINSKI FAKULTET"  Organization address address: SALATA 3 city: ZAGREB postcode: 10000 contact info Titolo: Ms. Nome: Smiljka Cognome: Vikic Topic Email: send email Telefono: +385 1 4566972 Fax: +385 1 4566724	HR (ZAGREB)	coordinator	598˙613.00
2	GENERA ISTRAZIVANJA DRUSTVO S OGRANICENOM ODGOVORNOSCU ZA PROIZVODNJU BIOTEHNOLOSKIH PROIZVODA  Organization address address: SVETONEDJELJSKA 2 city: KALINOVICA postcode: 10436 contact info Titolo: Dr. Nome: Hermann Cognome: Oppermann Email: send email Telefono: +385 1 3388761	HR (KALINOVICA)	participant	1˙474˙486.80
3	MEDIZINISCHE UNIVERSITAET WIEN  Organization address address: SPITALGASSE 23 city: WIEN postcode: 1090 contact info Titolo: Prof. Nome: Reinhard Cognome: Windhager Email: send email Telefono: +43 1 40400 4084 Fax: +43 1 40400 4029	AT (WIEN)	participant	599˙400.00
4	LINKOPINGS UNIVERSITET  Organization address address: CAMPUS VALLA city: LINKOPING postcode: 581 83 contact info Titolo: Prof. Nome: Per Cognome: Aspenberg Email: send email Telefono: +46 13 224166	SE (LINKOPING)	participant	459˙800.00
5	EUROPEAN RESEARCH AND PROJECT OFFICE GMBH  Organization address address: Science Park 1, Stuhlsatzenhausweg 69 city: SAARBRUECKEN postcode: 66123 contact info Titolo: Ms. Nome: Claudia Cognome: Giehl Email: send email Telefono: +49 681 9592 3378 Fax: +49 681 9592 3370	DE (SAARBRUECKEN)	participant	456˙125.00
6	MEDITOX S.R.O  Organization address address: POD ZAMKEM 279 city: KONAROVICE postcode: 28125 contact info Titolo: Dr. Nome: Martin Cognome: Slais Email: send email Telefono: +420 313 129 375 Fax: +420 313 129 366	CZ (KONAROVICE)	participant	404˙659.50
7	KLINICKI BOLNICKI CENTAR SESTRE MILOSRDNICE USTANOVA  Organization address address: VINOGRADSKA CESTA 29 city: ZAGREB postcode: 10000 contact info Titolo: Dr. Nome: Dragan Cognome: ?ur?evi? Email: send email Telefono: +358 98 235 554	HR (ZAGREB)	participant	402˙000.00
8	PAUL REGULATORY SERVICES LIMITED  Organization address address: FISHER HILL WAY 15 city: CARDIFF postcode: CF15 8DR contact info Titolo: Ms. Nome: Ruth Cognome: Paul Email: send email Telefono: 442921000000	UK (CARDIFF)	participant	374˙625.00
9	KLINICKI CENTAR UNIVERZITETA U SARAJEVU  Organization address address: BOLNICKA 25 city: SARAJEVO postcode: 71000 contact info Titolo: Prof. Nome: Lilijana Cognome: Oru? Email: send email Telefono: +387 33 668 415 Fax: +387 33 668 415	BA (SARAJEVO)	participant	360˙000.00
10	SGS VITROLOGY LIMITED  Organization address address: SOUTH AVENUE 5 CLYDEBANK city: GLASCOW postcode: G81 2LG contact info Titolo: Dr. Nome: Archie Cognome: Lovatt Email: send email Telefono: +44 141 952 0022	UK (GLASCOW)	participant	353˙340.00
11	SMART-MEDICO DOO  Organization address address: ZUPANOVA 5 city: ZAGREB postcode: 10000 contact info Titolo: Dr. Nome: Snjezana Cognome: Martinovic Email: send email Telefono: +385 1 2446 534 Fax: +385 1 2446 534	HR (ZAGREB)	participant	200˙040.00

Mappa

 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

 Obiettivo del progetto (Objective)

'Goals: We propose a regenerative medicine clinical trial of the therapeutic system OSTEOGROW for regenerating bone through harnessing a novel bone device to accelerate and enhance bone repair. The osteogenic device is composed of an autologous carrier and a biologically active recombinant human protein offering a therapeutic solution in bone regeneration superior to currently available options. The autologous carrier is a whole blood-derived coagulum device (WBCD) from the peripheral blood of a patient, which will act as an endogenous biocompatible material causing significantly less inflammatory reactions than currently used bone devices. The bone inducing molecule is the recombinant human bone morphogenetic protein 6 (BMP6) which binds to WBCD and is more potent than other BMPs in stimulating bone formation in preclinical animal models. The consortium members will scale-up the production of BMP6 from an already developed working cell bank to enter clinical trials on bone regeneration. The bone diseases we will treat locally with OSTEOGROW are acute radius fractures and recalcitrant non-unions of the tibia. These conditions are widespread and highly debilitating diseases for which such therapy holds great promise. Workflow: Preliminary pre-clinical data are already available, and clinical grade (GMP) BMP6 will be available before the beginning of the project to perform toxicology studies and to determine the final formulation of OSTEOGROW. Clinical trials will start within 18 months from the start of the project funding. Business strategy: SMEs Genera Research and BioTest will develop and validate the BMP6 production in their facilities. Consortium members from Medical University of Vienna, Sarajevo University Clinical Centre, Linkoping University Faculty of Health Sciences, Zagreb University Trauma Clinic, SMART Medico and Paul Regulatory Services will perform, monitor and coordinate clinical trials. OSTEOGROW will find a wide use in human and veterinary medicine.'

Introduzione (Teaser)

Bone fractures provoke a particularly painful and lengthy healing process, which applies mainly to elderly patients. Current treatment options are associated with inflammation and other undesirable side-effects.