NEPHROTOOLS

The potential of human kidney stem/progenitor cells for use in drug discovery and regenerative therapy programmes

 Coordinatore THE UNIVERSITY OF LIVERPOOL 

 Organization address address: Brownlow Hill, Foundation Building 765
city: LIVERPOOL
postcode: L69 7ZX

contact info
Titolo: Ms.
Nome: Jenny
Cognome: Lawson
Email: send email
Telefono: +44 151 7950314

 Nazionalità Coordinatore United Kingdom [UK]
 Totale costo 3˙832˙076 €
 EC contributo 3˙832˙076 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-2011-ITN
 Funding Scheme MC-ITN
 Anno di inizio 2011
 Periodo (anno-mese-giorno) 2011-12-01   -   2015-11-30

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF LIVERPOOL

 Organization address address: Brownlow Hill, Foundation Building 765
city: LIVERPOOL
postcode: L69 7ZX

contact info
Titolo: Ms.
Nome: Jenny
Cognome: Lawson
Email: send email
Telefono: +44 151 7950314

UK (LIVERPOOL) coordinator 896˙156.00
2    RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG

 Organization address address: SEMINARSTRASSE 2
city: HEIDELBERG
postcode: 69117

contact info
Titolo: Prof.
Nome: Norbert
Cognome: Gretz
Email: send email
Telefono: 496214000000
Fax: 496214000000

DE (HEIDELBERG) participant 657˙580.00
3    UNIVERSITA DEGLI STUDI DI TORINO

 Organization address address: Via Giuseppe Verdi 8
city: TORINO
postcode: 10124

contact info
Titolo: Prof.
Nome: Benedetta
Cognome: Bussolati
Email: send email
Telefono: 390117000000
Fax: 390117000000

IT (TORINO) participant 500˙817.00
4    LEIBNIZ-INSTITUT FUR POLYMERFORSCHUNG DRESDEN EV

 Organization address address: HOHE STRASSE 6
city: DRESDEN
postcode: 1069

contact info
Titolo: Ms.
Nome: Sandra
Cognome: Martinka
Email: send email
Telefono: +49 3514658599
Fax: +49 351465898599

DE (DRESDEN) participant 462˙404.00
5    UNIVERSITY COLLEGE LONDON

 Organization address address: GOWER STREET
city: LONDON
postcode: WC1E 6BT

contact info
Titolo: Ms.
Nome: Greta
Cognome: Borg-Carbott
Email: send email
Telefono: 442031000000
Fax: 442078000000

UK (LONDON) participant 261˙231.00
6    STICHTING KATHOLIEKE UNIVERSITEIT

 Organization address address: GEERT GROOTEPLEIN NOORD 9
city: NIJMEGEN
postcode: 6525 EZ

contact info
Titolo: Mr.
Nome: Wim
Cognome: Van Oijen
Email: send email
Telefono: +31 24 3619419
Fax: +31 24 3540529

NL (NIJMEGEN) participant 243˙363.00
7    MEDICAL RESEARCH INFRASTRUCTURE DEVELOPMENT AND HEALTH SERVICES FUND BY THE SHEBA MEDICAL CENTER

 Organization address address: TEL HASHOMER SHEBA MEDICAL CENTER
city: RAMAT GAN
postcode: 52621

contact info
Titolo: Ms.
Nome: Eve
Cognome: Keret
Email: send email
Telefono: +972 3 530 3207
Fax: +972 3 530 3800

IL (RAMAT GAN) participant 239˙740.02
8    KATHOLIEKE UNIVERSITEIT LEUVEN

 Organization address address: Oude Markt 13
city: LEUVEN
postcode: 3000

contact info
Titolo: Ms.
Nome: Sarah
Cognome: Malevé
Email: send email
Telefono: +32 16 320611
Fax: +32 16 326515

BE (LEUVEN) participant 228˙720.00
9    BIOMER TECHNOLOGY LTD

 Organization address address: SEYMOUR COURT 10 MANOR PARK
city: RUNCORN
postcode: WA7 1SY

contact info
Titolo: Mr.
Nome: Simon
Cognome: Dixon
Email: send email
Telefono: +44 1928 531888

UK (RUNCORN) participant 228˙043.00
10    SPHERITECH LIMITED

 Organization address address: THE HEATH BUSINESS AND TECHNICAL PARK
city: Runcorn
postcode: WA7 4QX

contact info
Titolo: Dr.
Nome: Donald
Cognome: Wellings
Email: send email
Telefono: 441929000000

UK (Runcorn) participant 114˙022.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

of    science    utilisation    models    stem    nephrotools    differentiation    bioelectronics    vitro    breakthroughs    measuring    kspc    problem    purpose    medicine    cellular    therapy    kidney    tools    cell    impact    multidisciplinary    therapies    morbidity    transplantation    electronic    disease    appropriate    dialysis    drug    regenerative    stage    options    function    significant    characterise    training    cells    health    discovery    generate    effectiveness    primary    treatment    esrd    kspcs    human    mortality    biomaterials    lines    lack    renal    progenitor    animal   

 Obiettivo del progetto (Objective)

'Renal disease is a global public health problem, with the incidence of end stage renal disease (ESRD) rising annually. Current treatment options for ESRD are dialysis or renal transplantation, which have significant drawbacks in terms of increased morbidity and mortality, besides placing an increasing economic burden on society. The development of interventions aimed at preventing ESRD, including drug- and cellular-based therapies, is made difficult by the lack of availability of primary human renal cells for in vitro drug testing and by our inability to accurately assess the effectiveness of cellular-based therapies in appropriate animal models. However, due to recent advances in the fields of stem cell science, biomaterials and bioelectronics, we have unprecedented opportunities to generate the following tools that will facilitate important breakthroughs in renal medicine: (i) human kidney-derived stem/progenitor cells (KSPCs) for drug discovery and cellular therapy; (ii) biomaterials for regulating the differentiation of the KSPCs in vitro for use in drug development programmes; (iii) electronic devices capable of measuring renal function, enabling the effectiveness of stem cell-based therapies to be properly evaluated. The overarching goal of the NephroTools ITN is to provide state-of-the-art multidisciplinary training for a cohort of 15 young researchers in order to equip them with the skills required to make a significant impact in renal medicine and the wider field of stem cell biotechnology. To achieve this goal, the training of each researcher will be based around a specific research project, coupled with placement periods, within a multidisciplinary and cross-sectoral Network that aims to evaluate the potential of human kidney stem/progenitor cells for use in drug discovery and regenerative therapy programmes.'

Introduzione (Teaser)

Regenerative treatments are increasingly gaining ground as effective alternatives to tissue replacement approaches. Researchers are thus looking to identify and characterise cells capable of restoring organ function.

Descrizione progetto (Article)

Renal disease constitutes a major health problem worldwide. The only treatment options for end stage renal disease (ESRD) are renal transplantation, which suffers from donor shortages, and dialysis, which is associated with high morbidity and mortality. Efforts to develop new drug- and cellular-based therapies are hampered by the lack of availability of primary human renal cells for in vitro drug testing and lack of appropriate animal models.

Advances in stem cell science, biomaterials and bioelectronics have the potential to facilitate breakthroughs in renal medicine. . Research tools such as human kidney-derived stem/progenitor cells (KSPCs) and devices for measuring renal function should facilitate drug discovery and allow the evaluation of cellular therapy.

In this context, the EU-funded http://www.nephrotools.com/ (NEPHROTOOLS) project aims to develop such tools for use in renal medicine. For this purpose, they will generate and characterise KSPC lines and optimise their utilisation for drug discovery purposes.

So far, researchers have generated a number of KSPC lines, characterised their gene expression profile and are currently investigating their nephrogenic potential. To direct differentiation of KSPCs into specialised renal cells, a number of biomimetic substrates have been designed and synthesised. The consortium is also developing physiological and pharmacological assays for the utilisation of KSPC lines in drug discovery.

Ongoing work is directed towards evaluating the capacity of these cells to ameliorate disease in rodent models of kidney injury. For this purpose, researchers have developed a miniaturised electronic device for measuring the glomerular filtration rate in animals.

Collectively, the activities of the NEPHROTOOLS study will determine the clinical applicability of KSPCs in terms of therapy and drug discovery. At the same time, it will provide multidisciplinary training to the next generation of researchers in the field of renal medicine. Given the great need for novel therapies to prevent the development of ESRD, the overall project outcome is anticipated to have significant impact in the treatment of kidney disease.

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