ACSAC

Aza-Claisen-Sakurai Approach to Cyclopentylamines

 Coordinatore QUEEN'S UNIVERSITY BELFAST 

 Organization address address: University Road
city: BELFAST
postcode: BT7 1NN

contact info
Titolo: Ms.
Nome: Pauline
Cognome: Mccann
Email: send email
Telefono: +44 28 90973229

 Nazionalità Coordinatore United Kingdom [UK]
 Totale costo 209˙033 €
 EC contributo 209˙033 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-2011-IIF
 Funding Scheme MC-IIF
 Anno di inizio 2012
 Periodo (anno-mese-giorno) 2012-07-04   -   2014-07-03

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    QUEEN'S UNIVERSITY BELFAST

 Organization address address: University Road
city: BELFAST
postcode: BT7 1NN

contact info
Titolo: Ms.
Nome: Pauline
Cognome: Mccann
Email: send email
Telefono: +44 28 90973229

UK (BELFAST) coordinator 209˙033.40

Mappa


 Word cloud

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compounds    aza    synthesis    cyclopentylamines   

 Obiettivo del progetto (Objective)

'Cyclopentylamines are ubiquitous compounds within nature and many pharmaceutical products. Their synthesis can be problematic with length and unselective sequences plaguing them. We aim to overcome this shortcoming by developing a new approach whereby we couple two well known reactions; the Aza-Claisen (or Aza-Cope) rearrangement and the Sakurai allylation. The expected outcomes of this research are a new method which is both rapid and selective for the synthesis of cyclopentylamines. We also intend to achieve the total synthesis of the compound (-)-Altemicidin, a highly substituted cyclopentylamine which exhibits potent antitumor and acaricidal properties. Any compounds produced will be screened against various disease states either here at Queen’s using the Centre for Cancer Research and Cell Biology or with our academic and industrial partners.'

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