NANOBIOMOFS

Nanoscale Metal–Organic Frameworks for Biomedical Applications

Coordinatore	FUNDACIO INSTITUT CATALA DE NANOCIENCIA I NANOTECNOLOGIA    more  Organization address address: CAMPUS DE LA UAB EDIFICI Q ICN2 city: BELLATERRA (BARCELONA) postcode: 8193 contact info Titolo: Ms. Nome: Marta Cognome: Balza Email: send email Telefono: 34935868310
Nazionalità Coordinatore	Spain [ES]
Totale costo	168˙896 €
EC contributo	168˙896 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2011-IEF
Funding Scheme	MC-IEF
Anno di inizio	2012
Periodo (anno-mese-giorno)	2012-03-01   -   2014-02-28

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	FUNDACIO INSTITUT CATALA DE NANOCIENCIA I NANOTECNOLOGIA  Organization address address: CAMPUS DE LA UAB EDIFICI Q ICN2 city: BELLATERRA (BARCELONA) postcode: 8193 contact info Titolo: Ms. Nome: Marta Cognome: Balza Email: send email Telefono: 34935868310	ES (BELLATERRA (BARCELONA))	coordinator	168˙896.40

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 Obiettivo del progetto (Objective)

'The project NanoBioMOFs (Nanoscale Metal–Organic Frameworks for Biomedical Applications) is a step forward to the researcher’s work undertaken during his postgraduate studies which comprised synthesising bulk Metal–Organic Frameworks (MOFs) for applications in gas storage, gas and liquid separation and molecular sensing. MOFs can be obtained from the connection of metal centres and organic ligands through the space in such a way that the structures obtained can be extended in one–, two– or three–dimensions. The applicant wishes to extend his knowledge in the same research area but from a completely different viewpoint, synthesising MOFs at the nanoscale regime for applications in drug delivery. To date, nanoparticle systems (polymer, iron or gold nanoparticles) have been used as drug delivery agents. This methodology has attracted much attention as it can improve many of the drawbacks of conventional therapy including high doses, rapid clearance, poor pharmacokinetics and strong side effects. Porous MOFs can be also used as drug delivery carriers due to their tunable host–guest properties and the ability to post–modify their internal surface. Although MOFs are excellent candidates to deliver drugs, they cannot be used in the form of traditional bulk but they have to be miniaturized at the nanometre scale. The aim of this project will be the synthesis of known and novel biocompatible, water–resistant MOFs based on biological ligands at the nanoscale, loading of MOFs with anticancer drugs and check their in vitro safety and therapeutic efficacy for chronic diseases such as cancer. This project allows the applicant to conduct truly interdisciplinary and inter–sectoral research, complementing his expertise in synthetic and materials chemistry in nanotechnology (Catalan Institute of Nanotechnology) and biomedicine (Biotechnology and Biomedicine Institute) at laboratories with long–standing collaboration, unique validation models and and state–of–the–art infrastructure.'

Introduzione (Teaser)

One of the most promising material types of the 21st century has unprecedented surface area with largely empty internal space. Utilising biologically relevant molecules to synthesise them, scientists have developed sensors and drug-delivery vehicles.