LOAD PROFILE

Development of a late-onset-Alzheimer’s disease (LOAD) profile for accurate diagnosis and identification of potential therapeutic approaches

Coordinatore	MEDIZINISCHE UNIVERSITAET WIEN    more  Organization address address: SPITALGASSE 23 city: WIEN postcode: 1090 contact info Titolo: Prof. Nome: Michael Cognome: Freissmuth Email: send email Telefono: +43 1 4277 64171 Fax: +43 1 4277 9623
Nazionalità Coordinatore	Austria [AT]
Totale costo	747˙300 €
EC contributo	747˙300 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2011-IAPP
Funding Scheme	MC-IAPP
Anno di inizio	2012
Periodo (anno-mese-giorno)	2012-10-01   -   2016-09-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	MEDIZINISCHE UNIVERSITAET WIEN  Organization address address: SPITALGASSE 23 city: WIEN postcode: 1090 contact info Titolo: Prof. Nome: Michael Cognome: Freissmuth Email: send email Telefono: +43 1 4277 64171 Fax: +43 1 4277 9623	AT (WIEN)	coordinator	283˙608.00
2	Randox Laboratories Ltd  Organization address address: Diamond Road 55 city: Crumlin postcode: BT29 4QY contact info Titolo: Dr. Nome: John Cognome: Lamont Email: send email Telefono: +44 28 9442 2413	UK (Crumlin)	participant	354˙518.00
3	UNIVERSITAT WIEN  Organization address address: UNIVERSITATSRING 1 city: WIEN postcode: 1010 contact info Titolo: Prof. Nome: Juergen Cognome: Koenig Email: send email Telefono: +43 1 4277 549 91	AT (WIEN)	participant	59˙320.00
4	OLBRZYMEK LESZEK TADEUSZ LEDO P.P.H.U. LESZEK OLBRZYMEK  Organization address address: ULICA GLINIANA 19 city: LODZ postcode: 91336 contact info Titolo: Ms. Nome: Sylwia Cognome: Olbrzymek Email: send email Telefono: +48 42 654 91 54	PL (LODZ)	participant	36˙706.00
5	POLITECHNIKA LODZKA  Organization address address: ULICA ZEROMSKIEGO 116 city: LODZ postcode: 90 924 contact info Titolo: Prof. Nome: Bogdan Cognome: Walkowiak Email: send email Telefono: +48 42 6312335	PL (LODZ)	participant	13˙148.00

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 Obiettivo del progetto (Objective)

'Late-onset Alzheimer’s disease (LOAD) is a neurodegenerative disorder that currently affects 2% of the population in industrialized countries; the risk of LOAD increases in individuals beyond the age of 70 and it is predicted that the incidence of LOAD will increase 4-fold within the next 50 years which may cause a great socioeconomic problem. Early diagnosis and evidence-based interventions that improve the condition of LOAD patients are not available. Numerous studies revealed that LOAD is an age-related multifactorial disease, which is evident on the protein level in hardly accessible cerebrospinal fluid by decreased beta amyloid and increased hyperphosphorylated tau protein. The Medical University of Vienna and the diagnostics company Randox have already characterised LOAD related proteins in blood platelets that reflect features of neurons. These proteins indicate multifactorial interactions in LOAD leading to our holistic approach. The present project, unlike others, will simultaneously determine (epi)genetic, protein-specific, and metabolic parameters of LOAD patients. On the genetic level LOAD is associated with Apolipoprotein E4 polymorphism. Decreased vitamin B12 and folate and increased homocysteine levels are metabolic dysfunctions that may be linked to epigenetic changes in methylation patterns of LOAD relevant genes. The University of Vienna will identify metabolic LOAD markers in blood. The MUW will perform complementary (epi)genetic and proteomic studies, and will generate algorithms for multi-arrays. Significant (epi)genetic aberrations in LOAD will be translated into assays of a DNA Chip at Randox. In addition, the SME Ledo and the Polish University Politechnika Lodzka join their expertise to develop a standardised ready-to-use platelet isolation column for platelet purification. Only this intensive transfer of knowledge will achieve combined analysis of these different types of LOAD biomarkers which should allow accurate diagnosis and offer approaches to targeted therapy.'